OMNIPHOBIC PAPER BASED SMART BANDAGE DEVICES
The present disclosure discloses a novel omniphobic, paper-based, smart bandage (OPSB) devices, and the methods to make and use the omniphobic, paper-based, smart bandage devices. The OPSB device of the present disclosure provides a simple, low-cost, and non-invasive strategy to monitor open wound status wirelessly. This disclosure also provides the demonstration of in-vivo early detection and monitoring of pressure ulcers using wireless smart bandages.
1 . A device comprising:
a bandage comprising a first surface with an adhesive layer configured to face healthy skin or wounded tissue and a second surface on an opposite side of the first surface, wherein the adhesive layer has openings;
a sensor comprising a porous, omniphobic pad on which are printed two or more electrodes between which is dropcasted a PANi-EB/Ag comprising a polyaniline-emraldine base and silver microflake composite film, wherein the sensor is placed on the adhesive layer of the bandage and measures a pH of a wound exudate using an impedance;
an absorbent pad, which has been placed on the sensor; and
a detachable potentiostat comprising an electrochemical sensing application chip and an impedance analyzer chip to perform electrochemical measurements and impedance spectroscopy, respectively, a microcontroller, a battery, and a communication module, wherein the detachable potentiostat is interfaced through the openings of the adhesive layer with the sensor for detecting and monitoring a wound condition.
2 . The device of claim 1 , wherein the wound condition to be monitored comprises a bacterial infection.
3 . The device of claim 1 , wherein the porous omniphobic pad is chemically modified pad by treating the porous pad with RSiCl 3 fluorinated alkyltrichlorosilane.
4 . The device of claim 1 , wherein the silver in the PANi-EB/Ag composite film has a particle size of 2-5 μm.
5 . A device comprising:
a bandage comprising a first surface with an adhesive layer configured to face healthy skin or wounded tissue and a second surface on an opposite side of the first surface wherein the adhesive layer has openings;
a sensor comprising a porous, omniphobic pad on which are printed seven electrodes in a hexagonal array which are optionally coated with a hydrogel, wherein the sensor is placed on the adhesive layer of the bandage and measures a tissue impedance for detecting and monitoring of a pressure ulcer;
an absorbent pad, which has been placed on the sensor; and
a detachable potentiostat comprising an electrochemical sensing application chip and an impedance analyzer chip to perform electrochemical measurements and impedance spectroscopy, respectively, a microcontroller, a battery, and a communication module, which interfaces through the openings of the adhesive layer with the sensor for detecting and monitoring the pressure ulcer.
6 . The device of claim 5 , wherein the porous omniphobic pad is chemically modified pad by treating the porous pad with RSiCl 3 fluorinated alkyltrichlorosilane.
7 . The device of claim 5 , wherein the pressure ulcer is detected by measuring a magnitude and a phase of an impedance by surface mapping before the pressure ulcer is visible on the surface of the skin of the subject and correlating the magnitude and the phase of the impedance to a degree of tissue damage caused by the pressure ulcer.