Granted Patent B2

US 12,691,150 · App. 18/639,598 · Granted Jul 28, 2026

Inventors: Simon Alvis (Oxfordshire, GB); Magdalena Kieltyka (Oxfordshire, GB)

Assignee: Akamis Bio, Inc.

A61K35/761A61K9/0019A61K9/08A61K47/10A61K47/183A61K47/20A61K47/26

Abstract

Claims (25)

1 . A liquid formulation suitable for a group B adenovirus, comprising:

a) a group B adenovirus;

b) 15 to 25% v/v glycerol;

c) methionine or arginine; and

d) buffer,

wherein the pH of the formulation is in the range of 8.0 to 9.6 and wherein the formulation does not comprise a divalent cation.

2 . The formulation of claim 1 , wherein the formulation does not comprise a sugar.

3 . The formulation of claim 1 , wherein the formulation is for intravenous administration.

4 . The formulation of claim 3 , wherein the formulation is for administration by slow injection or by infusion.

5 . The formulation of claim 1 , wherein the formulation further comprises a surfactant.

6 . The formulation of claim 5 , wherein the surfactant is polysorbate, optionally wherein the polysorbate is polysorbate 80.

7 . The formulation of claim 6 , wherein the formulation comprises 0.05-0.15% polysorbate.

8 . The formulation of claim 1 , wherein the formulation comprises 0.01-0.3 mM methionine.

9 . The formulation of claim 1 , wherein the formulation comprises 5-20 mM arginine.

10 . The formulation of claim 1 , wherein the buffer is selected from meglumine, glycine, TRIS, and combinations thereof.

11 . The formulation of claim 1 , wherein the formulation does not comprise HEPES buffer.

12 . The formulation of claim 1 , wherein the formulation comprises:

a) 15 to 20% v/v glycerol;

b) 1 to 1.5% v/v ethanol;

c) 0.1 to 0.2% v/v polysorbate 80;

d) 0.2 to 0.3 mM methionine; and

e) 10 to 20 mM arginine.

13 . The formulation of claim 1 , wherein the group B adenovirus is replication competent.

14 . The formulation of claim 1 , wherein the group B adenovirus is Ad11 or Enadenotucirev (EnAd).

15 . The formulation of claim 1 , wherein the formulation further comprises 0.1 to 1.5% v/v ethanol.

Assignments (3)

Priority Claims (1)

Continuity (2)

References Cited (77)