PERFORATED TISSUE MATRIX
The present disclosure relates to tissue matrix products. The products can includes tissue matrices that have holes or perforations located at certain positions to improve certain in vivo functions without substantial loss of strength or other important properties.
1 . A tissue matrix product, comprising:
a flexible sheet comprising a tissue matrix, wherein the flexible sheet includes a group of holes passing through the tissue matrix, wherein the holes are formed in a pattern comprising a repeating motif of five holes, the motif repeating in at least two columns, the flexible sheet including a perimeter region where no holes are present, the perimeter region being sized to allow an area for passage of sutures or other connection devices or to provide a non-perforated section for fixation to tissue such as fascia, wherein a size of the perimeter region is in a range from 1.5 to 3 cm.
2 . The product of claim 1 , wherein the repeating motif has a rectangular shape that includes a hole positioned at each corner of the rectangular shape and one hole positioned at a center of the rectangular shape.
3 . The product of claim 1 , wherein the rectangular shape has a first dimension and a second dimension such that the first dimension is greater than the second dimension.
4 . The product of claim 3 , wherein adjacent columns are spaced apart from one another by a distance different from the second dimension, wherein the distance defines an area without holes.
5 . The product of claim 1 , wherein the motif is repeated in at least three columns.
6 . The product of claim 1 , wherein the motif is repeated in at least two rows.
7 . The product of claim 6 , wherein a distance between each column is greater than a distance between each row.
8 . The product of claim 1 , wherein each hole has a maximum dimension between about 1.5 mm and 2.5 mm.
9 . The product of claim 1 , wherein the suture retention strength of any hole of the group of holes is at least 80% of the suture retention strength of a region of the tissue matrix without the hole.
10 . The product of claim 1 , wherein the motif in a first column of the two columns is not laterally aligned with the motif in a second column of the two columns.
11 . A tissue matrix product, comprising:
a flexible sheet comprising a tissue matrix, wherein the flexible sheet includes a group of between 10 and 80 holes passing through the tissue matrix, wherein the flexible sheet comprises a rectangular shape having a width between 10 cm and 30 cm and a length between 10 cm and 30 cm, and the holes have a maximum dimension between about 1.5 mm and 2.5 mm, and wherein the holes are arranged in a pattern such that a uniaxial tensile strength measured in any direction along the sheet is at least 60% of the uniaxial tensile strength of a sheet without the group of holes.
12 . The product of claim 11 , wherein the flexible sheet of tissue matrix with the group of holes has a uniaxial tensile strength measured in any direction along the sheet that is at least 70% of the uniaxial tensile strength of a sheet without the group of holes.
13 . The product of claim 11 , wherein the flexible sheet includes a group of between 14 and 64 holes.
14 . The product of claim 11 , wherein the flexible sheet has a width between 10 cm and 25 cm and a length between 15 cm and 30 cm.
15 . The product of claim 14 , wherein the holes have a maximum dimension between about 1.8 mm and 2.5 mm.
16 . The product of claim 11 , wherein the suture retention strength of any one of the holes is at least 80% of the suture retention strength of a region of the tissue matrix without the hole.
17 . The product of claim 11 , wherein the holes are formed in a pattern comprised of a repeating motif of five holes.
18 . The product of claim 17 , wherein the motif is repeated in at least two columns or at least three columns.
19 . The product of claim 17 , wherein the motif is repeated in at least two rows or at least three rows.
20 . The product of claim 19 , wherein a distance between each column is greater than a distance between each row.