IP Library › Granted Patent US 12,402,816
Granted Patent B2
US 12,402,816 · App. 18/643,195 · Granted Sep 2, 2025

Medical monitoring device for harmonizing physiological measurements

Inventors: Jesse Chen (Foothill Ranch, CA); Sean Merritt (Lake Forest, CA); Cristiano Dalvi (Lake Forest, CA); Ferdyan Lesmana (Irvine, CA); Hung The Vo (Fountain Valley, CA); Kevin Hughes Pauley (Lake Forest, CA); Jeroen Poeze (Rancho Santa Margarita, CA); Ruiqi Long (Irvine, CA); Stephen L. Monfre (Rancho Santa Margarita, CA)
Assignee: Willow Laboratories, Inc.
A61B5/14532A61B5/0075A61B5/0205A61B5/7203A61B5/7278A61B5/0066A61B5/0261A61B5/0295A61B5/0531A61B5/1075A61B5/1079A61B5/14551A61B5/442A61B5/443A61B2560/02A61B2576/02
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Quick Facts
Patent No.
US 12,402,816
App. No.
18/643,195
Granted
Sep 2, 2025
Kind
B2
Abstract

Systems, methods, apparatuses, and medical devices for harmonizing data from a plurality of non-invasive sensors are described. A physiological parameter can be determined by harmonizing data between two or more different types of non-invasive physiological sensors interrogating the same or proximate measurement sites. Data from one or more first non-invasive sensors can be utilized to identify one or more variables that are useful in one or more calculations associated with data from one or more second non-invasive sensors. Data from one or more first non-invasive sensors can be utilized to calibrate one or more second non-invasive sensors. Non-invasive sensors can include, but are not limited to, an optical coherence tomography (OCT) sensor, a bio-impedance sensor, a tissue dielectric constant sensor, a plethysmograph sensor, or a Raman spectrometer.

Claims (47)

1. A system for determining a physiological parameter of an individual, the system comprising:

a sensor apparatus comprising:

a first noninvasive sensor configured to generate first data, wherein the first data is responsive to light reflection, light refraction, light absorption, light attenuation, optical coherence tomography, capacitance, or bioimpedance of a particular region of tissue of the individual,

a second noninvasive sensor configured to generate second data, wherein the second data corresponds to a light scattering signature of the particular region of the tissue, and

a housing configured to secure the first and second noninvasive sensors; and

one or more processors configured to:

receive the first data,

receive the second data,

filter the second data based at least in part on the first data,

estimate an analyte level based at least in part on the filtered second data, and

output a visual or audible indication of the analyte level.

2. The system of claim 1 , wherein the first noninvasive sensor is an optical coherence tomography (OCT) device.

3. The system of claim 1 , wherein the first noninvasive sensor is a capacitance sensor.

4. The system of claim 1 , wherein the first noninvasive sensor is a bioimpedance sensor.

5. The system of claim 1 , wherein the first noninvasive sensor is a plethysmography sensor.

6. The system of claim 1 , wherein the sensor apparatus comprises a third noninvasive sensor configured to generate third data responsive to light reflection, light refraction, light absorption, light attenuation, optical coherence tomography, capacitance, or bioimpedance of a particular region of the particular region of tissue, wherein the third data is different from the first data, and wherein the one or more processors is further configured to receive the third data, and wherein the one or more processors is configured to select a focal depth or focal length of the second data based at least in part on the third data.

7. The system of claim 1 , wherein the first noninvasive sensor and second noninvasive sensor are configured to concurrently interrogate the particular region of the tissue.

8. The system of claim 1 , wherein the first noninvasive sensor and second noninvasive sensor are configured to concurrently interrogate the particular region of the tissue.

9. The system of claim 1 , wherein the analyte level comprises a blood analyte level.

10. The system of claim 9 , wherein the blood analyte level comprises a glucose level.

11. A method for determining a physiological parameter of an individual, the method comprising:

receiving, from a sensor apparatus comprising a first noninvasive sensor and a second noninvasive sensor, first data associated with the first noninvasive sensor, wherein the first data is responsive to light reflection, light refraction, light absorption, light attenuation, optical coherence tomography, capacitance, or bioimpedance of a particular region of tissue of an individual, wherein the second noninvasive sensor comprises a Raman spectrometer;

receiving, from the sensor apparatus, second data associated with a second noninvasive sensor, wherein the second data corresponds to a light scattering signature of the particular region of the tissue;

filtering the second data based on an effect of the first data on the second data;

determining an analyte level based at least in part on the filtered second data;

outputting a visual or audible indication of the analyte level; and

modifying, based at least in part on the analyte level, a treatment of the individual performed by at least one of a drug administration device, a ventilator, a fluid IV, a fan, or a thermostat.

12. The method of claim 11 , comprising:

receiving, from the sensor apparatus, third data associated with a third noninvasive sensor, wherein the third data is responsive to light reflection, light refraction, light absorption, light attenuation, optical coherence tomography, capacitance, or bioimpedance of a particular region of the particular region of tissue, wherein the third data is different from the first data; and

selecting a focal depth or focal length of the second data based at least in part on the third data.

13. The method of claim 11 , comprising interrogating, using the first and second noninvasive sensors, the particular region of tissue.

14. The method of claim 13 , wherein the interrogating using the first and second noninvasive sensors is simultaneous.

15. The method of claim 11 , wherein the first noninvasive sensor is an optical coherence tomography (OCT) device.

16. The method of claim 11 , wherein the first noninvasive sensor is a capacitance sensor.

17. The method of claim 11 , wherein the first noninvasive sensor is a bioimpedance sensor.

18. The method of claim 11 , wherein the first noninvasive sensor is a plethysmography sensor.

19. A system for determining a physiological parameter of an individual, the system comprising:

a sensor apparatus comprising:

at least one noninvasive sensor configured to generate first data, wherein the first data is responsive to light reflection, light refraction, light absorption, light attenuation, optical coherence tomography, capacitance, or bioimpedance of a particular region of tissue of the individual; and

a housing configured to secure the at least one noninvasive sensor; and

one or more processors configured to:

receive the first data,

receive second data responsive to Raman spectra of the particular region of tissue of the individual,

filter the Raman spectra based at least in part on the first data,

estimate an analyte level based at least in part on the filtered Raman spectra, and

output a visual or audible indication of the analyte level.

20. The system of claim 19 , wherein the sensor apparatus comprises a noninvasive sensor configured to generate third data responsive to light reflection, light refraction, light absorption, light attenuation, optical coherence tomography, capacitance, or bioimpedance of a particular region of the particular region of tissue, wherein the third data is different from the first data, and wherein the one or more processors is further configured to receive the third data, and wherein the one or more processors is configured to select a focal depth or focal length of the Raman spectra based at least in part on the third data.

Assignments (2)
CHANGE OF NAME Recorded Jun 25, 2025
From: CERCACOR LABORATORIES, INC.
To: WILLOW LABORATORIES, INC.
Reel/Frame 071721/0701 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 23, 2025
From: MONFRE, STEPHEN L.; CHEN, JESSE; DALVI, CRISTIANO; LESMANA, FERDYAN; VO, HUNG THE; PAULEY, KEVIN HUGHES; POEZE, JEROEN; LONG, RUIQI; MERRITT, SEAN
To: CERCACOR LABORATORIES, INC.
Reel/Frame 071685/0001 →
Continuity (5)
Continuation 17324396 · May 19, 2021
Continuation 16034743 · Jul 13, 2018
Provisional Application 62667983 · May 7, 2018
Provisional Application 62532273 · Jul 13, 2017
Related Publication 20240324910A1 · Oct 3, 2024
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