SYSTEM FOR TREATING EMBOLISM AND ASSOCIATED DEVICES AND METHODS
Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, positioning a distal portion of a catheter proximate to the clot material within the blood vessel. The method can further include coupling a pressure source to the catheter via a tubing subsystem including a valve or other fluid control device and, while the valve is closed, activating the pressure source to charge a vacuum. The valve can then be opened to apply the vacuum to the catheter to thereby aspirate at least a portion of the clot material from the blood vessel and into the catheter.
1 . A system for treating clot material comprising a pulmonary embolism in the vasculature of a patient, the system comprising:
a catheter defining a lumen and having a distal end portion, wherein the catheter is configured to be intravascularly advanced through the vasculature of the patient such that the distal end portion of the catheter is positioned proximate to the pulmonary embolism, and wherein the catheter has a size of 16 French or greater;
a hemostasis valve configured to selectively provide fluid access to the lumen of the catheter;
a clot canister;
a filter positioned within the clot canister;
an aspiration source;
a valve between the catheter and the clot canister; and
a fluid path extending through the lumen of the catheter, through the valve, through the clot canister, and to the aspiration source, wherein
the valve is movable between (a) a first position that inhibits fluid flow along the fluid path from the lumen of the catheter to the clot canister and (b) a second position that permits fluid flow along the fluid path from the lumen of the catheter to the clot canister,
the aspiration source is configured to generate vacuum pressure in the clot canister while the valve is in the first position,
the clot canister is configured to store the vacuum pressure while the valve is in the first position, and
the valve is movable from the first position while the vacuum pressure is stored in the clot canister to the second position, thereby applying the vacuum pressure to the lumen of the catheter such that at least a portion of the pulmonary embolism and blood are aspirated through the lumen of the catheter into the clot canister, wherein the filter is configured to filter the blood from the at least portion of the pulmonary embolism.
2 . The system of claim 1 wherein the catheter has a size of 20 French or greater.
3 . The system of claim 1 wherein the valve is user-actuatable to move been the first position and the second position.
4 . The system of claim 1 wherein the hemostasis valve includes one or more buttons actuatable by a user to provide the fluid access to the lumen of the catheter.
5 . The system of claim 1 wherein the filter is removable from the clot canister to provide access to the filtered pulmonary embolism.
6 . The system of claim 1 wherein the lumen of the catheter has a first diameter, and wherein the fluid path through the valve has a second diameter that is the same as or greater than the first diameter.
7 . The system of claim 1 , further comprising at least one tube fluidly coupling the valve to (a) the lumen of the catheter and (b) the clot canister, wherein the fluid path further extends through the at least one tube, wherein the lumen of the catheter has a first diameter, and wherein the fluid path through the valve and the at least one tube has a second diameter that is the same as or greater than the first diameter.
8 . The system of claim 1 wherein the fluid path through the lumen of the catheter, through the valve, and to the clot canister does not include any restrictions or narrowing of the fluid path.
9 . The system of claim 1 wherein the aspiration source has a volume of 60 cubic centimeters or greater.
10 . The system of claim 1 wherein the clot canister is separate from the aspiration source.
11 . The system of claim 1 wherein the valve includes a lever graspable by a user to move the valve between the first position and the second position.
12 . The system of claim 1 wherein the aspiration source is an electric pump.
13 . The system of claim 1 wherein the hemostasis valve comprises:
a tubular member defining a lumen;
a filament extending at least partially around the tubular member, wherein the filament is moveable between (a) a first position wherein the filament circumferentially constricts the lumen of the tubular member and (b) a second position wherein the filament is moved such that the lumen of the tubular member is at least partially open; and
a biasing member configured to bias the filament to the first position.
14 . The system of claim 1 wherein the hemostasis valve comprises:
a tubular member defining a lumen;
a pair of filaments extending at least partially around the tubular member, wherein the filaments are moveable between (a) a first position wherein the filaments circumferentially constrict the lumen of the tubular member and (b) a second position wherein the filaments are moved such that the lumen of the tubular member is at least partially open; and
a biasing member configured to bias the filaments to the first position.
15 . A system for treating clot material comprising a pulmonary embolism in the vasculature of a patient, the system comprising:
a catheter defining a lumen and having a distal end portion, wherein the catheter is configured to be intravascularly advanced through the vasculature of the patient such that the distal end portion of the catheter is positioned proximate to the pulmonary embolism, and wherein the catheter has a size of 16 French or greater;
an aspiration container;
a valve between the aspiration container and the catheter; and
a fluid path extending through the lumen of the catheter, through the valve, and to the aspiration container, wherein
the valve is movable between (a) a first position that inhibits fluid flow along the fluid path from the lumen of the catheter to the aspiration container and (b) a second position that permits fluid flow along the fluid path from the lumen of the catheter to the aspiration container,
the aspiration container is configured to store vacuum pressure while the valve is in the first position, and
the valve is movable from the first position while the vacuum pressure is stored in the aspiration container to the second position, thereby applying the vacuum pressure to the lumen of the catheter such that at least a portion of the pulmonary embolism is aspirated into the lumen of the catheter.
16 . The system of claim 15 wherein the catheter has a size of 20 French or greater.
17 . The system of claim 15 wherein the valve is user-actuatable to move been the first position and the second position.
18 . The system of claim 15 , further comprising a hemostasis valve configured to selectively provide fluid access to the lumen of the catheter.
19 . The system of claim 18 wherein the hemostasis valve includes one or more buttons actuatable by a user to provide the fluid access to the lumen of the catheter.
20 . The system of claim 18 wherein the hemostasis valve comprises:
a tubular member defining a lumen;
a filament extending at least partially around the tubular member, wherein the filament is moveable between (a) a first position wherein the filament circumferentially constricts the lumen of the tubular member and (b) a second position wherein the filament is moved such that the lumen of the tubular member is at least partially open; and
a biasing member configured to bias the filament to the first position.
21 . The system of claim 18 wherein the hemostasis valve comprises:
a tubular member defining a lumen;
a pair of filaments extending at least partially around the tubular member, wherein the filaments are moveable between (a) a first position wherein the filaments circumferentially constrict the lumen of the tubular member and (b) a second position wherein the filaments are moved such that the lumen of the tubular member is at least partially open; and
a biasing member configured to bias the filaments to the first position.
22 . The system of claim 15 wherein the fluid path through the lumen of the catheter and through the valve does not include any restrictions or narrowing of the fluid path.
23 . The system of claim 15 , further comprising at least one tube fluidly coupling the valve to the lumen of the catheter, wherein the fluid path further extends through the at least one tube, wherein the lumen of the catheter has a first diameter, and wherein the fluid path through the valve and the at least one tube has a second diameter that is the same as or greater than the first diameter.
24 . The system of claim 15 wherein the valve includes a lever graspable by a user to move the valve between the first position and the second position.
25 . The system of claim 15 , further comprising an aspiration source, wherein the aspiration source is fluidly coupled to the aspiration container, and wherein the aspiration source is configured to generate the vacuum pressure in the aspiration container while the valve is in the first position.
26 . The system of claim 25 wherein the aspiration source has a volume of 60 cubic centimeters or greater.
27 . The system of claim 25 wherein the aspiration source comprises an electric pump.
28 . The system of claim 25 wherein the aspiration source comprises a syringe.
29 . The system of claim 15 wherein the aspiration container comprises a syringe.