Granted Patent B2

US 12,629,503 · App. 18/665,410 · Granted May 19, 2026

Inventors: Ling-Kang Tong (Hayward, CA); Daniela Tamar Buchman (Mountain View, CA); Jackie Joe Hancock (Berkeley, CA); Nicholas Terzulli (Oakland, CA)

Assignee: MORNINGSIDE VENTURE INVESTMENTS LIMITED

A61M35/10A61M5/14248A61M2005/14268A61M2205/0272A61M2205/14A61M2205/8206

Abstract

Claims (44)

1 . A two-part bioactive agent delivery system, the system comprising:

a disposable part comprising

an agent reservoir,

a transdermal patch communicating with the agent reservoir and adapted to transdermally deliver the bioactive agent to a user, the transdermal patch having a bottom surface adapted to contact skin of the user and a top surface opposite the bottom surface;

a rail configured to extend substantially parallel with a longitudinal axis of the two-part bioactive agent delivery system; and

a gas permeable membrane disposed over the top surface of the transdermal patch;

a reusable part comprising:

a power source and control electronics, the control electronics being adapted to deliver bioactive agent dissolved in a solvent from the agent reservoir to the transdermal patch;

a sliding element configured to engage with the rail of the disposable part and form a gap between the reusable part and the disposable part; and

a solvent removal element disposed in the gap between the disposable part and the reusable part to create a flow path for gaseous solvent to flow from the gas permeable membrane to ambient air around the bioactive agent delivery system; and

a vent positioned between the gas permeable membrane and the gap,

wherein the vent is configured to expose between 5-30% of a surface of the gas permeable membrane.

2 . The system of claim 1 , wherein the reusable part further comprises one or more spacers configured to engage with the disposable part and maintain the gap between the reusable part and the disposable part.

3 . The system of claim 2 , wherein the one or more spacers are further configured to engage with a bottom surface of the reusable part to maintain the gap between the reusable part and the disposable part.

4 . The system of claim 2 , wherein the one or more spacers are substantially equally disposed around the vent.

5 . The system of claim 1 , wherein the disposable part further comprises a chassis configured to include the agent reservoir and the rail.

6 . The system of claim 5 , further comprising spacers configured to include a diameter of less than ten percent of a width of the chassis.

7 . The system of claim 5 , wherein the chassis includes a thicker section and a thinner section, wherein the thinner section partly defines the gap.

8 . The system of claim 7 , wherein the chassis further includes a ramp ledge configured to transition between the thicker section and the thinner section.

9 . The system of claim 1 , further comprising a diagonal strut configured to divide the vent into a plurality of vents.

10 . The system of claim 1 , wherein the disposable part comprises the vent.

11 . The system of claim 1 , further comprising at least one drainage port formed in an exterior surface of the reusable part or the disposable part.

12 . The system of claim 1 , wherein the disposable part further comprises an agent outlet communicating with the agent reservoir and the transdermal patch.

13 . The system of claim 12 , wherein the agent outlet is configured to provide the bioactive agent dissolved in the solvent to a space between the transdermal patch and the gas permeable membrane.

14 . A method of delivering a bioactive agent, the method comprising:

connecting a sliding element of a reusable part of a delivery system to a rail of a disposable part of the delivery system to form a flow path within a gap between the reusable part and the disposable part;

delivering the bioactive agent dissolved in a solvent from a reservoir of the disposable part to a transdermal membrane of the disposable part; and

allowing the solvent to evaporate and flow from the transdermal membrane through a gas permeable membrane and a vent disposed over the gas permeable membrane to the gap and along the flow path to ambient air around the delivery system,

wherein the vent exposes between 5-30% of a surface of the gas permeable membrane.

15 . The method of claim 14 , wherein delivering the bioactive agent comprises controlling, with the reusable part, movement of the bioactive agent dissolved in the solvent from the reservoir to the transdermal membrane.

16 . The method of claim 15 , wherein controlling movement of the bioactive agent comprises actuating a valve.

17 . The method of claim 15 , further comprising detecting a connection between the disposable part and the reusable part.

18 . The method of claim 17 , wherein detecting a connection comprises sensing a magnetic field.

19 . A two-part bioactive agent delivery system, the system comprising:

a disposable part comprising

an agent reservoir,

a transdermal patch communicating with the agent reservoir and adapted to transdermally deliver the bioactive agent to a user, the transdermal patch having a bottom surface adapted to contact skin of the user and a top surface opposite the bottom surface;

a rail configured to extend substantially parallel with a longitudinal axis of the two-part bioactive agent delivery system; and

a gas permeable membrane disposed over the top surface of the transdermal patch;

a reusable part comprising:

a power source and control electronics, the control electronics being adapted to deliver bioactive agent dissolved in a solvent from the agent reservoir to the transdermal patch;

a sliding element configured to engage with the rail of the disposable part and form a gap between the reusable part and the disposable part; and

a solvent removal element comprising a gap disposed between the disposable part and the reusable part to create a flow path for gaseous solvent to flow from the gas permeable membrane to ambient air around the bioactive agent delivery system; and

a vent configured to expose between 5-30% of a surface of the gas permeable membrane to the gap.

Assignments (3)

Continuity (4)

References Cited (400)