IP Library › Granted Patent US 12,134,661
Granted Patent B1
US 12,134,661 · App. 18/668,012 · Granted Nov 5, 2024

Covalent multi-specific antibody

Inventors: Zhenhao Zhou (Chengdu, CN); Jie Zhang (Chengdu, CN); Xiaoqing Wang (Chengdu, CN)
Assignee: Chimagen Biosciences, Ltd.
C07K16/468C07K2317/31C07K2317/56C07K2317/64
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Quick Facts
Patent No.
US 12,134,661
App. No.
18/668,012
Granted
Nov 5, 2024
Kind
B1
Abstract

Disclosed herein are novel bispecific and tri-specific antibodies with increased stability and use thereof for therapy.

Claims (5)

1. An engineered multi-specific antibody that bins to CD3, CD19 and CD20, and comprises:

(i) a first polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 10;

(ii) a second polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 11,

(iii) a third polypeptide comprising the amino acid sequence of set forth in SEQ ID NO: 12; and

(iv) a fourth polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 13.

Assignments (6)
CHANGE OF ADDRESS Recorded Apr 16, 2025
From: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED
To: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED
Reel/Frame 071351/0192 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 17, 2024
From: XNEXT BIOSCIENCES
To: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED
Reel/Frame 069607/0832 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE NAME PREVIOUSLY RECORDED AT REEL: 69008 FRAME: 450. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT . Recorded Oct 25, 2024
From: CHIMAGEN BIOSCIENCES
To: XNEXT BIOSCIENCES
Reel/Frame 069267/0104 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 24, 2024
From: CHIMAGEN BIOSCIENCES, LTD.
To: CHIMAGEN BIOSCIENCES
Reel/Frame 069007/0739 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 24, 2024
From: CHIMAGEN BIOSCIENCES
To: XNET BIOSCIENCES
Reel/Frame 069008/0450 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 30, 2024
From: ZHOU, ZHENHAO; ZHANG, JIE; WANG, XIAOQING
To: CHIMAGEN BIOSCIENCES, LTD.
Reel/Frame 069074/0677 →