CRYSTALLINE FORM OF TOLEBRUTINIB AND PREPARATION METHOD THEREOF
Disclosed is a crystalline form of Tolebrutinib (hereinafter referred to as “Compound I”) and preparation methods thereof, pharmaceutical compositions containing the crystalline form, and uses of the crystalline form for preparing BTK inhibitor drugs and drugs for treating multiple sclerosis. The provided crystalline form of Tolebrutinib has one or more improved properties and has significant value for future drug optimization and development.
1 . A crystalline form of Compound I, wherein the X-ray powder diffraction pattern comprises at least one characteristic peak at 2theta values of 7.7°±0.2°, 11.0°±0.2°, and 22.8°±0.2° using CuKα radiation
2 . The crystalline form of Compound I according to claim 1 , wherein the X-ray powder diffraction pattern comprises at least one characteristic peak at 2theta values of 12.0°±0.2°, 16.1°±0.2°, and 18.5°±0.2° using CuKα radiation.
3 . The crystalline form of Compound I according to claim 1 , wherein the X-ray powder diffraction pattern comprises at least one characteristic peak at 2theta values of 13.6°±0.2°, 20.1°±0.2°, and 24.8°±0.2° using CuKα radiation.
4 . The crystalline form of Compound I according to claim 1 , wherein the X-ray powder diffraction pattern is substantially as depicted in FIG. 2 using CuKα radiation.
5 . A process for preparing the crystalline form according to claim 1 , wherein the process comprises: adding the solid of Compound I into a ketone or an ether, stirring and separating to obtain the crystalline form.
6 . The process according to claim 5 , wherein said ketone is a ketone of C3-C6, and said ether is an ether of C5.
7 . The process according to claim 5 , wherein said ketone is 4-methyl-2-pentanone, and said ether is methyl tert-butyl ether.
8 . The process according to claim 5 , wherein a temperature of stirring is from room temperature to 55° C., and a time of stirring is more than 25 hours.
9 . A pharmaceutical composition, wherein said pharmaceutical composition comprises a therapeutically effective amount of the crystalline form according to claim 1 , and pharmaceutically acceptable excipients.
10 . A method of inhibiting BTK, comprising administering to a subject in need thereof a therapeutically effective amount of the crystalline form according to claim 1 .
11 . A method of treating multiple sclerosis, comprising administering to a subject in need thereof a therapeutically effective amount of the crystalline form according to claim 1 .