Compounds for the Degradation of EGFR Kinase
Disclosed herein are novel bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase ligand moieties, methods of preparation, and uses thereof.
1 - 76 . (canceled)
77 . A compound selected from
or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or a tautomer thereof, or a deuterated analog thereof.
78 . A pharmaceutical composition comprising a compound of claim 77 or a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof, or a deuterated analog, together with a pharmaceutically acceptable excipient.
79 . A method of treating a disease that can be affected by EGFR modulation, comprises administrating a subject in need thereof an effective amount of a compound of claim 77 or a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof or a deuterated analog thereof.
80 . The method of claim 79 , wherein the disease is cancer.
81 - 82 . (canceled)
83 . The compound of claim 77 , wherein the compound is
84 . The compound of claim 77 , wherein the compound is
85 . The compound of claim 77 , wherein the compound is
86 . The compound of claim 77 , wherein the compound is
87 . The compound of claim 77 , wherein the compound is
88 . The compound of claim 77 , wherein the compound is
89 . The compound of claim 77 , wherein the compound is
90 . The compound of claim 77 , wherein the compound is
91 . The compound of claim 77 , wherein the compound is
92 . The compound of claim 77 , wherein the compound is
93 . The compound of claim 77 , wherein the compound is
94 . The compound of claim 77 , wherein the compound is
95 . The compound of claim 77 , wherein the compound is
96 . The compound of claim 77 , wherein the compound is
97 . The compound of claim 77 , wherein the compound is
98 . The compound of claim 77 , wherein the compound is
99 . The compound of claim 77 , wherein the compound is
100 . The compound of claim 77 , wherein the compound is
101 . The compound of claim 77 , wherein the compound is
102 . The compound of claim 77 , wherein the compound is
103 . The method of claim 79 , wherein the disease is selected from pancreatic cancer, breast cancer, glioblastoma multiforme, head and neck cancer, and non-small cell lung cancer.