ALBUMIN BINDING DOMAIN FUSION PROTEINS
Compositions that include an albumin binding domain and a fusion partner (e.g., a cytokine or a binding moiety) are provided. Such therapeutics have increased serum half-life and find use in applications where one or more such therapeutics are needed, for example, in oncology applications.
1 . An IL-12/IL-15 albumin binding domain fusion protein comprising the amino acid sequence of SEQ ID NO: 225.
2 . A nucleic acid encoding the 12/IL-15 albumin binding domain fusion protein of claim 2 .
3 . An expression vector comprising the nucleic acid of claim 3 .
4 . A host cell comprising the nucleic acid of claim 2 or the expression vector of claim 3 .
5 . A method of making an 12/IL-15 albumin binding domain fusion protein comprising culturing the host cell of claim 4 under conditions wherein the 12/IL-15 albumin binding domain fusion protein is expressed, and recovering the 12/IL-15 albumin binding domain fusion protein.