NANOPARTICLES FOR USE IN PHOTODYNAMIC THERAPIES AND METHODS OF MAKING, EVALUATING AND USING THE SAME
A nanocomposition for use in treating cardiac, oncologic, bariatric, or dermatologic indications, conditions and diseases condition using phthalocyanine dye, such as IR700. A nanocomposition having IR700, an 8PEG nanoparticle and a RGD, or iRGD targeting agent. Administering a product comprising IR700 to a patient, whereby the IR700 is delivered to the target tissue, and found in only target tissue; and administering light to activate the IR700, thereby producing an ROS.
1 . A nanocomposition comprising:
a. a photosensitizer (PS), wherein the photosensitizer is a phthalocyanine dye;
b. a nanoparticle (NP); wherein the nanoparticle is 8PEG; and,
c. a targeting agent (TA), wherein the targeting agent is a peptide.
2 . A nanocomposition according to claim 1 wherein the photosensitizer (PS) is IR700.
3 . A nanocomposition according to claim 1 wherein the targeting agent is an RGD peptide.
4 . A nanocomposition according to claim 1 wherein the targeting agent is iRGD.
5 . A nanocomposition according to claim 1 wherein the photosensitizer (PS) loading is between 0 and 5 PS's per 8PEG.
6 . A nanocomposition according to claim 1 wherein the photosensitizer (PS) loading is preferably between 1 and 3 PS's per 8PEG.
7 . A nanocomposition according to claim 1 wherein the photosensitizer (PS) loading is more preferably between 2 and 3 PS's per 8PEG.
8 . A nanocompostion according to claim 1 comprising
a. a photosensitizer (PS), wherein the photosensitizer is IR700
b. a nanoparticle (NP); wherein the nanoparticle is 8PEG; and,
c. a targeting agent (TA), wherein the targeting agent is iRGD.
9 . A nanocomposition according to claim 8 wherein the photosensitizer (PS) loading is between 0 and 5 PS's per 8PEG.
10 . A nanocomposition according to claim 8 wherein the photosensitizer (PS) loading is between 1 and 3 PS's per 8PEG.
11 . A nanocomposition according to claim 8 wherein the photosensitizer (PS) loading is between 2 and 3 PS's per 8PEG.
12 . A nanocomposition, for use in treating pathogenic conditions m animals, the nanocomposition comprising:
a. a photosensitizer (PS), wherein the photosensitizer is a phthalocyanine dye;
b. a nanoparticle (NP); wherein the nanoparticle is selected from the group of 8PEG, 8PEGA and 8PEGMAL;
c. a targeting agent (TA), wherein the targeting agent is a targeting peptide; and,
d. wherein the nanocomposition is configured for providing a photodynamic therapy for the pathogen condition.
13 . A nanocomposition according to claim 12 wherein the photosensitizer (PS) is IR700.
14 . A nanocomposition according to claim 12 wherein the targeting agent is an RGD peptide.
15 . A nanocomposition according to claim 12 wherein the targeting agent is iRGD.
16 . A nanocomposition according to claim 12 wherein the photosensitizer (PS) loading is between 0 and 5 PS's per 8PEG.
17 . A nanocomposition according to claim 12 wherein the photosensitizer (PS) loading is preferably between 1 and 3 PS's per 8PEG.
18 . A nanocomposition according to claim 12 wherein the photosensitizer (PS) loading is more preferably between 2 and 3 PS's per 8PEG.
19 . A nanocomposition according to claim 12 in which the ratio of TA to PS is 2.5:1 and greater.
20 . A nanocomposition according to claim 12 in which the ratio of TA to PS is 3:1 and greater.
21 - 42 . (canceled)