IP Library Patent Application 18752726
Patent Application
App. No. 18/752,726

SOLID FORMS OF ((S)-5-((1-(6-CHLORO-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)ETHYL)AMINO)-1-METHYL-6-OXO-1,6-DIHYDROPYRIDINE-2-CARBONITRILE

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Quick Facts
Patent No.
US None
App. No.
18/752,726
Abstract

The present disclosure reports solid forms of ((S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile.

Claims (24)

1 - 20 . (canceled)

21 . A solid form of Compound 1:

Compound 1

characterized by an X-ray Powder Diffraction (XRPD) having diffractions at angles (2 theta+0.2) of 6.3, 23.6, and 27.8.

22 . The solid form of claim 21 characterized by an X-ray Powder Diffraction (XRPD) having diffractions at angles (2 theta+0.2) of 6.3, 23.6, and 27.8, corresponding to d-spacing (angstroms±0.2) of 14.0, 3.8, and 3.2, respectively.

23 . The solid form of claim 21 characterized by a differential scanning calorimetry (DSC) thermogram with an endothermic event observed at about 256.6° C.

24 . The solid form of claim 22 characterized by a differential scanning calorimetry (DSC) thermogram with an endothermic event observed at about 256.6° C.

25 . The solid form of claim 21 characterized by a dynamic vapor sorption (DVS) showing maximum water uptake of 0.25% w/w at 25° C./90% RH.

26 . The solid form of claim 22 characterized by a dynamic vapor sorption (DVS) showing maximum water uptake of 0.25% w/w at 25° C./90% RH.

27 . The solid form of claim 21 , characterized by a DSC endothermic event at about 256.6° C., wherein the DSC is obtained by heating at 10° C./min from about 20° C. to about 300° C. using dry nitrogen to purge the system and the following parameters:

Parameters

DSC

Pan Type

Aluminum pan, closed

Temperature

RT-250° C.

Ramp rate

10° C./min

Purge gas

N 2

28 . A solid form of olutasidenib, characterized by at least one of the following characteristics:

(i) an X-ray Powder Diffraction (XRPD) having diffractions at angles (2 theta±0.2) of 6.3, 23.6, and 27.8;

(ii) a differential scanning calorimetry (DSC) thermogram with an endothermic event observed at about 256.6° C.; and

(iii) a dynamic vapor sorption (DVS) showing maximum water uptake of 0.25% w/w at 25° C./90% RH.

Assignments (1)
SECURITY INTEREST Recorded May 8, 2026
From: RIGEL PHARMACEUTICALS, INC.
To: MIDCAP FUNDING IV TRUST
Reel/Frame 075576/0880 →