SOLID FORMS OF ((S)-5-((1-(6-CHLORO-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)ETHYL)AMINO)-1-METHYL-6-OXO-1,6-DIHYDROPYRIDINE-2-CARBONITRILE
The present disclosure reports solid forms of ((S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile.
1 - 20 . (canceled)
21 . A solid form of Compound 1:
Compound 1
characterized by an X-ray Powder Diffraction (XRPD) having diffractions at angles (2 theta+0.2) of 6.3, 23.6, and 27.8.
22 . The solid form of claim 21 characterized by an X-ray Powder Diffraction (XRPD) having diffractions at angles (2 theta+0.2) of 6.3, 23.6, and 27.8, corresponding to d-spacing (angstroms±0.2) of 14.0, 3.8, and 3.2, respectively.
23 . The solid form of claim 21 characterized by a differential scanning calorimetry (DSC) thermogram with an endothermic event observed at about 256.6° C.
24 . The solid form of claim 22 characterized by a differential scanning calorimetry (DSC) thermogram with an endothermic event observed at about 256.6° C.
25 . The solid form of claim 21 characterized by a dynamic vapor sorption (DVS) showing maximum water uptake of 0.25% w/w at 25° C./90% RH.
26 . The solid form of claim 22 characterized by a dynamic vapor sorption (DVS) showing maximum water uptake of 0.25% w/w at 25° C./90% RH.
27 . The solid form of claim 21 , characterized by a DSC endothermic event at about 256.6° C., wherein the DSC is obtained by heating at 10° C./min from about 20° C. to about 300° C. using dry nitrogen to purge the system and the following parameters:
Parameters
DSC
Pan Type
Aluminum pan, closed
Temperature
RT-250° C.
Ramp rate
10° C./min
Purge gas
N 2
28 . A solid form of olutasidenib, characterized by at least one of the following characteristics:
(i) an X-ray Powder Diffraction (XRPD) having diffractions at angles (2 theta±0.2) of 6.3, 23.6, and 27.8;
(ii) a differential scanning calorimetry (DSC) thermogram with an endothermic event observed at about 256.6° C.; and
(iii) a dynamic vapor sorption (DVS) showing maximum water uptake of 0.25% w/w at 25° C./90% RH.