HIGH-POTENCY VITAMIN C AND SUGAR ALCOHOL TOPICAL FORMULATIONS
Topical formulations of L-ascorbic acid dissolved in a combination of a sugar alcohol agent, and a non-aqueous skin-compatible solvent are provided. The formulations are storage stable for an extended period of time without significant degradation of the L-ascorbic acid in the composition, and have desirable physical properties. The topical formulations can include high concentrations of the L-ascorbic acid. Topical compositions of this disclosure find use in treating or preventing a variety of cosmetic and/or dermatological conditions as well as to reduce the appearance of chronological and/or environmentally-caused skin aging.
1 . A storage stable topical liquid composition comprising:
a. 10% to 20% by weight ascorbic acid;
b. 5% to 10% by weight of xylitol; and
c. less than 10% by weight in total of one or more optional additional components selected from an antioxidant, a skin lightening agent, a chemical exfoliant, a moisturizing agent, and an anti-inflammatory agent;
d. dissolved in a non-aqueous skin-compatible solvent selected from the group consisting of: 1,3 propanediol, 1,2 propanediol, 1,3 butanediol, 1,5 pentanediol, 1,2 hexanediol, 1,6 hexanediol, glycerol, and a combination thereof,
wherein the composition demonstrates less than 5 mol % degradation of the ascorbic acid after storage for 8 weeks at 40±2° C. in a sealed container.
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12 . The composition of claim 1 , wherein the composition comprises 7 to 10% by weight of xylitol.
13 . The composition of claim 1 , wherein the composition comprises 10 to 15% by weight of ascorbic acid.
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17 . The composition of any one of claim 1 , wherein the solvent is 1,3 propanediol, or a mixture of 1,3 propanediol and 1,2 hexanediol.
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19 . The composition of claim 1 , wherein the composition comprises the one or more additional components.
20 . The composition of claim 19 , wherein the antioxidant comprises ferulic acid.
21 . The composition of claim 19 , wherein the chemical exfoliant comprises is salicylic acid.
22 . The composition of claim 19 , wherein the skin lightening agent comprises azelaic acid.
23 . The composition of claim 19 , wherein the moisturizing agent comprises urea or glycerin.
24 . The composition of claim 19 , wherein the anti-inflammatory agent comprises madecassoside.
25 . The composition of claim 19 , wherein the antioxidant comprises Pinus pinaster bark extract.
26 . The composition of claim 19 , wherein the composition comprises 0.5% salicylic acid.
27 . The composition of claim 19 , wherein the composition comprises 0.5% ferulic acid.
28 . The composition of claim 19 , wherein the composition comprises 5% of azelaic acid.
29 . The composition of claim 19 , wherein the composition comprises 5% of azelaic acid, 0.5% salicylic acid, and 0.5% ferulic acid.
30 . The composition of claim 19 , wherein the composition comprises 0.5% Pinus pinaster bark extract.
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35 . The composition of claim 1 , wherein the ascorbic acid is dissolved at a concentration that is above its maximum concentration in the solvent alone.
36 . The composition of claim 1 , wherein the composition comprises:
a. 15% to 20% by weight ascorbic acid;
b. 7% to 10% by weight of xylitol; and
c. less than 10% by weight in total of one or more optional additional components selected from the moisturizing agent urea, the chemical exfoliant salicylic acid, and the antioxidant ferulic acid;
d. dissolved in 1,3 propanediol or 1,2 propanediol.
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45 . A ready-to-use topical preparation in a multi-use container which is pre-filled with a storage stable topical composition of claim 1 .
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51 . The composition of claim 19 , wherein:
the antioxidant comprises ferulic acid;
the skin lightening agent comprises azelaic acid;
the chemical exfoliant comprises salicylic acid; and
the anti-inflammatory agent comprises madecassoside.