COMPOSITIONS AND METHODS FOR INHIBITING FACTOR D
The application discloses methods and compositions for the inhibition of the alternative complement pathway. The methods and compositions involve the use of aptamers for inhibiting complement Factor D. The application further provides anti-Factor D aptamers for the treatment of dry age-related macular degeneration, geographic atrophy, wet age-related macular degeneration or Stargardt disease.
1 - 66 . (canceled)
67 . An aptamer that selectively binds to a self-inhibitory loop of complement Factor D.
68 . An aptamer that selectively binds to an exosite of complement Factor D.
69 . A method of treating a subject having a disease or disorder, the method comprising administering to the subject the aptamer of claim 67 , thereby treating the subject.
70 . The method of claim 69 , wherein the disease or disorder is an ocular disease or disorder.