AROMATIC-CATIONIC PEPTIDES AND USES OF SAME
The disclosure provides compositions and methods relating to aromatic-cationic peptides. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof. For example, the peptides may be administered to subjects in need of a mitochondrial-targeted antioxidant.
1 .- 23 . (canceled)
24 . An aromatic-cationic peptide consisting of the amino acid sequence D-Arg-4-methoxy-2,6-dimethyltyrosine-Lys-Phe-OH, or a pharmaceutically acceptable salt thereof.
25 . A pharmaceutical composition comprising the aromatic-cationic peptide or pharmaceutically acceptable salt thereof of claim 1 .
26 . The pharmaceutical composition of claim 2 further comprising a pharmaceutically acceptable carrier.
27 . A method of reducing the number of mitochondria undergoing mitochondrial permeability transition (MPT), or preventing mitochondrial permeability transitioning in a mammal in need thereof, the method comprising administering to the mammal an effective amount of the aromatic-cationic peptide or pharmaceutically acceptable salt thereof of claim 1 .
28 . A method for reducing oxidative damage in a mammal in need thereof, the method comprising administering to the mammal an effective amount of the aromatic-cationic peptide or pharmaceutically acceptable salt thereof of claim 1 .
29 . A method for increasing the ATP synthesis rate in a mammal in need thereof, the method comprising administering to the mammal an effective amount of the aromatic-cationic peptide or pharmaceutically acceptable salt thereof of claim 1 .