DEVICE FOR OCULAR ACCESS
The present invention provides devices to access the suprachoroidal space or sub-retinal space in an eye via a minimally invasive transconjunctival approach. The devices may also be used after a partial dissection, for example after dissection of the outer scleral layer of the eye, and using the device within the dissection to access the suprachoroidal space or the sub-retinal space.
1 . A method of administering a therapeutic substance to a suprachoroidal space (SCS) of an eye without piercing a retina of the eye, the method comprising:
inserting a distal end portion of a puncture member into a sclera of the eye, the puncture member defining a lumen therethrough;
with the distal end portion of the puncture member disposed within the sclera, advancing an elongate member distally through the lumen of the puncture member to displace a choroid of the eye relative to the sclera to at least one of create or expand the SCS; and
with the SCS created or expanded, conveying through the lumen of the puncture member the therapeutic substance into the SCS.
2 . The method of claim 1 , further comprising:
after advancing the elongate member to create or expand the SCS and before conveying the therapeutic substance, withdrawing the elongate member proximal to the distal end portion of the puncture member.
3 . The method of claim 1 , further comprising:
contacting an outer surface of the eye with a stopper associated with the puncture member to control a depth of entry of the puncture member during the inserting.
4 . The method of claim 1 , wherein the inserting includes inserting the distal end portion of the puncture member tangentially relative to a natural curvature of the eye.
5 . The method of claim 1 , wherein the elongate member is a wire.
6 . The method of claim 5 , wherein the distal end of the wire is rounded.
7 . The method of claim 1 , further comprising:
prior to the inserting, dissecting an outer portion of the eye.
8 . The method of claim 1 , wherein the puncture member is a hollow needle.
9 . The method of claim 1 , further comprising:
viewing, via an imaging system that is external to the eye, the elongate member extending beyond a terminal end of the puncture member and in contact with the choroid, and the distal end portion of the puncture member within the SCS.
10 . The method of claim 1 , wherein the puncture member is associated with a syringe configured to convey the therapeutic substance through the lumen of the puncture member.
11 . The method of claim 1 , wherein the elongate member has a blunt tip.
12 . A method of administering a therapeutic substance to a target region of an eye, the method comprising:
inserting a distal end portion of a puncture member into a first portion of the eye,
with the distal end portion of the puncture member disposed within the first portion, advancing an elongate member distally relative to the puncture member to displace a second portion of the eye relative to the first portion to at least one of create or expand the target region, the target region being disposed between the first portion and the second portion;
with the target region created or expanded, withdrawing the elongate member proximally relative to the puncture member; and
conveying through the lumen of the puncture member the therapeutic substance into the target region.
13 . The method of claim 12 , wherein the conveying occurs after the withdrawing is initiated.
14 . The method of claim 12 , further comprising:
contacting an outer surface of the eye with a stopper associated with the puncture member to control a depth of entry of the puncture member during the inserting.
15 . The method of claim 12 , wherein the inserting includes inserting the distal end portion of the puncture member tangentially relative to a natural curvature of the eye.
16 . The method of claim 12 , wherein the elongate member is a wire.
17 . The method of claim 16 , wherein a distal end of the wire is rounded.
18 . The method of claim 12 , wherein the puncture member is a hollow needle.
19 . The method of claim 12 , viewing, via an imaging system that is external to the eye, the elongate member extending beyond a terminal end of the puncture member and in contact with the second portion, and the distal end portion of the puncture member within the target region.
20 . The method of claim 12 , wherein the puncture member is associated with a syringe configured to convey the therapeutic substance through the lumen of the puncture member.
21 . The method of claim 12 , wherein the elongate member has a blunt tip.
22 . The method of claim 12 , wherein the first portion is a sclera of the eye, the second portion is a choroid of the eye, and a target region is the suprachoroidal space of the eye.
23 . The method of claim 12 , wherein the target region is a subretinal space of the eye.