BIOMARKERS FOR OVARIAN CANCER
The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition. The biomarkers can be detected by SELDI mass spectrometry.
1 - 36 . (canceled)
37 . A kit comprising: (a) a solid support comprising at least one capture reagent attached thereto, wherein the capture reagent binds at least one biomarker from a first group consisting of the biomarkers of Tables 1, 3 and 4; and (b) instructions for using the solid support to detect a biomarker of Tables 1, 3 and 4.
38 . The kit of claim 37 comprising instructions for using the solid support to detect a biomarker selected from the group consisting of: ApoCl, Hemoglobin alpha/beta, ApoAII, ApoCII, Calgranulin C, Calgranulin C (truncated form), Calgranulin A and IgG heavy chain.
39 . The kit of claim 37 comprising instructions for using the solid support to detect each of the biomarkers: ApoCl, Hemoglobin alpha/beta, ApoAII, ApoCII, Calgranulin C, Calgranulin C (truncated form), Calgranulin A and IgG heavy chain.
40 . The kit of claim 37 comprising instructions for using the solid support to detect a biomarker selected from the group consisting of: ApoCl, ApoAII, ApoCII, Calgranulin A, Calgranulin C, Calcyclin, and Transthyretin.
41 . The kit of claim 37 comprising instructions for using the solid support to detect each of the biomarkers: ApoCl, ApoAII, ApoCII, Calgranulin A, Calgranulin C, Calcyclin, and Transthyretin.
42 . The kit of claim 39 , further comprising instructions for using the solid support to detect CA125.
43 . The kit of claim 37 , wherein the solid support comprising a capture reagent is a SELDI probe.
44 . The kit of claim 37 , wherein the capture reagent is a hydrophobic adsorbent, an anion exchange adsorbent, a cation exchange adsorbent and a metal chelate adsorbent.
45 . The kit of claim 37 , additionally comprising: (c) a container containing at least one of the biomarkers of Tables 1, 3 and 4.
46 . The kit of claim 37 , additionally comprising: (c) a cation exchange chromatography sorbent.
47 . A kit comprising: (a) a solid support comprising at least one capture reagent attached thereto, wherein the capture reagents bind at least one biomarker selected from the group consisting of the biomarkers of Tables 1, 3 and 4; and (b) a container containing at least one of the biomarkers.
48 . The kit of claim 47 , wherein the container contains at least one biomarker selected from the group consisting of: ApoCl, Hemoglobin alpha/beta, ApoAII, ApoCII, Calgranulin C, Calgranulin C (truncated form), Calgranulin A and IgG heavy chain.
49 . The kit of claim 47 , wherein the container contains each of the following biomarkers: ApoCl, Hemoglobin alpha/beta, ApoAII, ApoCII, Calgranulin C, Calgranulin C (truncated form), Calgranulin A and IgG heavy chain.
50 . The kit of claim 47 , wherein the container contains at least one biomarker selected from the group consisting of: ApoCl, ApoAII, ApoCII, Calgranulin A, Calgranulin C, Calcyclin, and Transthyretin.
51 . The kit of claim 47 , wherein the container contains each of the following biomarkers: ApoCl, ApoAII, ApoCII, Calgranulin A, Calgranulin C, Calcyclin, and Transthyretin.
52 . The kit of claim 49 , wherein the container further contains CA125.
53 . The kit of claim 47 , wherein the solid support comprising a capture reagent is a SELDI probe.
54 . The kit of claim 47 , additionally comprising: (c) a cation exchange chromatography sorbent.
55 . The kit of claim 47 , wherein the capture reagent is a member selected from the group consisting of a hydrophobic adsorbent, an anion exchange adsorbent, a cation exchange adsorbent and a metal chelate adsorbent.
56 - 68 . (canceled)