IP Library › Granted Patent US 12,329,812
Granted Patent B2
US 12,329,812 · App. 18/801,174 · Granted Jun 17, 2025

Nucleic acid vaccines

Inventors: Giuseppe Ciaramella (Sudbury, MA); Axel Bouchon (Kleinmacknow, DE); Eric Yi-Chun Huang (Boston, MA)
Assignee: ModernaTX, Inc.
A61K39/145A61K9/0019A61K9/1271A61K9/5123A61K9/5146A61K31/7105A61K39/12A61K39/155A61K39/39A61K48/00C12N7/00A61K2039/53A61K2039/545A61K2039/55555C12N2760/16122C12N2760/16134C12N2760/16234
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Quick Facts
Patent No.
US 12,329,812
App. No.
18/801,174
Granted
Jun 17, 2025
Kind
B2
Abstract

The invention relates to compositions and methods for the preparation, manufacture, and therapeutic use of ribonucleic acid vaccines comprising polynucleotide molecules encoding one or more antigens.

Claims (1)

1. A vaccine comprising a messenger ribonucleic acid (mRNA) formulated in a lipid nanoparticle, wherein the mRNA comprises an open reading frame encoding an influenza hemagglutinin protein, wherein the open reading frame comprises nucleosides consisting of N1-methylpseudouridine, adenosine, guanosine, and cytidine, and wherein the vaccine comprises from 25-100 μg of the mRNA.

Assignments (2)
SECURITY INTEREST Recorded Nov 19, 2025
From: MODERNATX, INC.
To: ARES CAPITAL CORPORATION, AS AGENT
Reel/Frame 073634/0354 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 21, 2025
From: CIARAMELLA, GIUSEPPE; HUANG, ERIC YI-CHUN; BOUCHON, AXEL
To: MODERNATX, INC.
Reel/Frame 070583/0759 →