COMPOSITIONS FOR SMALL MOLECULE THERAPEUTIC AGENT COMPOUNDS
A composition comprising an aqueous suspension comprising a small molecule therapeutic agent and an organic acid is described. The small molecule therapeutic agent is a base and has a water solubility at room temperature of less than about 1.0 g/L. The organic acid has a water solubility at room temperature of between 0.1 and 10, has a molar mass of less than 500 grams per mole, and/or maintains a pH of the suspension in its environment of use of between 3.0-6.5. The organic acid enhances the solubility of the small molecule therapeutic agent and when present in stoichiometric excess, the organic acid drives release of the small molecule therapeutic agent into a buffered environment of use for prolonged periods of, for example, six months to one year. Devices comprising the compositions and methods of treatment are also described.
1 . A device, comprising:
a housing member configured for subcutaneous implantation, the housing member defining a reservoir and comprising an opening for fluid communication between the reservoir and an environment of use;
a composition within the reservoir, the composition comprising (i) a therapeutic agent that has a water solubility at 25° C. of less than 1.0 g/L and (ii) an organic acid that is an amino-derivative of benzoic acid and that has a molar mass of less than about 500 grams/mole,
wherein the organic acid is present in a molar excess relative to the therapeutic agent;
wherein the composition in its environment of use forms a heterogeneous aqueous mixture comprising a soluble form of the therapeutic agent and a soluble form of the organic acid,
wherein the composition comprise an amount of the therapeutic agent sufficient for a therapeutic effect for a period of at least about 30 days upon release of the soluble form of the therapeutic agent from the device via the opening at a controlled release rate for the period.
2 . The device of claim 1 , wherein the opening comprises a porous partition comprising one or more pores to permit passage of the soluble form of the therapeutic agent and the soluble form of the organic acid.
3 . The device of claim 2 , wherein the porous partition retains in the reservoir for the period an insoluble form of therapeutic agent and an insoluble form of organic acid.
4 . The device of claim 1 , wherein the heterogeneous aqueous mixture comprises an aqueous fraction comprising the soluble form of the therapeutic agent and the soluble form of the organic acid, particles of a salt form of the therapeutic agent and particles of the organic acid.
5 . The device of claim 1 , wherein the controlled release rate is a substantially zero order rate of release for the period.
6 . The device of claim 1 , wherein the controlled release rate provides a therapeutic effect for the period.
7 . The device of claim 1 , wherein the controlled release rate is a substantially linear rate of release for the period that provides a therapeutic effect.
8 . The device of claim 1 , wherein the therapeutic agent is an antipsychotic medication.
9 . The device of claim 1 , wherein the therapeutic agent is selected from the group consisting of risperidone, olanzapine, paliperidone, aripiprazole, brexpiprazole, or asenapine.
10 . The device of claim 1 , wherein the organic acid is para-aminobenzoic acid.
11 . The device of claim 1 , wherein the organic acid is 2-aminobenzoic acid.
12 . The device of claim 1 , wherein the organic acid is present in a stoichiometric excess of 105% to 1000% relative to the therapeutic agent.
13 . The device of claim 1 , wherein, after the period, the aqueous heterogenous mixture comprises an amount of the organic acid that is approximately equal to or above its saturation concentration in an aqueous solution.
14 . An drug delivery device, comprising:
a non-erodible housing member defining an internal reservoir and comprising a porous partition positioned on the housing member;
contained within the reservoir, a composition comprised of an amount of risperidone and an amount of para-aminobenzoic acid (PABA), the amount of PABA being a molar excess amount relative to the amount of risperidone;
wherein the composition hydrates to form an aqueous heterogeneous mixture comprising a soluble form of risperidone, an insoluble form of risperidone, a soluble form of PABA and an insoluble form of PABA,
wherein the soluble form of risperidone is released from the device via the porous partition over a period of at least about four weeks and the insoluble form of risperidone and the insoluble form of PABA are retained in the reservoir.
15 . The device of claim 14 , wherein risperidone is released from the device in a therapeutically effective amount for the period.
16 . The device of claim 14 , wherein, after the period, the aqueous heterogenous mixture comprises an amount of PABA that is approximately equal to or above its saturation concentration in an aqueous solution.
17 . The device of claim 14 , wherein the amount of PABA is a molar excess of between about 105% to 1000% relative to the amount of risperidone.
18 . The device of claim 14 , wherein the amount of PABA is at least about 150% molar excess relative to the amount of risperidone.
19 . The device of claim 14 , wherein the soluble form of risperidone is released from the device at a substantially zero order rate of release for the period.
20 . The device of claim 19 , wherein the substantially zero order rate of release provides a therapeutic effect for the period.
21 . The device of claim 14 , wherein the soluble form of risperidone is released from the device at a substantially linear rate of release for the period to provide a therapeutic effect for the period.
22 . A method for sustained, controlled delivery of a therapeutic agent, comprising:
providing a device according to claim 1 ; and
implanting the device into a subject in need.
23 . A method to treat schizophrenia, comprising:
providing a composition according to claim 14 ; and
implanting the device into a subject in need.