Granted Patent
B2
US 12,305,156 · App. 18/810,388 · Granted May 20, 2025
Systems, devices, and methods for fluid control in a cell processing system
Inventors:
Lily Elizabeth Burkeen (San Francisco, CA); Kelly F. Curran (San Francisco, CA); Wilson Wai Toy (San Francisco, CA); Matthias Weber (South San Francisco, CA)
Assignee:
Cellares Corporation
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Abstract
The present disclosure relates to systems, devices, and methods for automated fluid control within a cell processing system. In an embodiment, the present disclosure relates to a cartridge having a fluidic manifold comprising a first end panel, a second end panel, and a central panel connecting the first and second end panels, where each of the first and second end panels comprises a plurality of fluidic pathways model therein and a plurality of valves for controlling fluid flow through the plurality of fluidic pathways.
Claims (18)
1. A cartridge for cell processing comprising:
a fluidic manifold comprising a first end panel, a second end panel, and a central panel connecting the first and second end panels, wherein each of the first and second end panels comprises a plurality of fluidic pathways molded therein and a plurality of valves for controlling fluid flow through the plurality of fluidic pathways.
2. The cartridge of claim 1 , wherein the first end panel further comprises at least one window configured for optical detection.
3. The cartridge of claim 2 , wherein the at least one window comprises a bubble sensing window.
4. The cartridge of claim 1 , wherein the first end panel further comprises a bubble trap.
5. The cartridge of claim 1 , wherein the second end panel further comprises at least one fluid extraction port.
6. The cartridge of claim 5 , wherein the at least one fluid extraction port comprises a needleless injection port.
7. The cartridge of claim 1 , wherein at least one of the plurality of valves comprises a pinch valve.
8. The cartridge of claim 1 , wherein the central panel comprises a plurality of fluidic pathways.
9. The cartridge of claim 8 , wherein the plurality of fluidic pathways of the central panel are fluidically connected to the plurality of fluidic pathways of each of the first and second end panels.
10. The cartridge of claim 8 , wherein the central panel further comprises at least one pressure sensor configured to monitor fluid flow through the plurality of fluidic pathways of the central panel.
11. The cartridge of claim 8 , wherein the plurality of fluidic pathways of the central panel are fluidically connected to one or more pumps.
12. The cartridge of claim 8 , wherein the central panel is coupled to a vent manifold configured to provide sterile air to the plurality of fluidic pathways of the central panel.
13. The cartridge of claim 8 , wherein the central panel is coupled to a degassing module comprising an air permeable membrane.
14. The cartridge of claim 1 , wherein the central panel connects the first end panel and the second end panel via first and second bridges.
15. The cartridge of claim 1 , wherein the fluidic manifold is fluidically connected to one or more modules of the cartridge.
16. The cartridge of claim 15 , wherein the one or more modules of the cartridge are selected from the group consisting of an elutriation module, an electroporation module, a spinoculation module, and a cell sorting module.
17. The cartridge of claim 1 , wherein the first end panel is fluidically connected to a first bioreactor module and the second end panel is fluidically connected to a second bioreactor module.
Assignments (2)
SECURITY INTEREST
Recorded May 5, 2026
From: CELLARES CORPORATION
To: TRINITY CAPITAL INC.
Reel/Frame 075545/0558 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 8, 2024
From: BURKEEN, LILY ELIZABETH; CURRAN, KELLY F.; TOY, WILSON WAI; WEBER, MATTHIAS
To: CELLARES CORPORATION
Reel/Frame 069208/0916 →
Continuity (2)
Provisional Application
63520859
· Aug 21, 2023
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