Compositions and Methods for Treating Dopamine Disorders
Compositions comprising clathrin nanoparticles and methods for treating dopamine-associated addictions, disorders, and neurodegenerative diseases using the same.
1 . A method for treating a human subject having or at risk for developing a dopamine disorder comprising administering to the human subject a therapeutically effective amount of a composition comprising:
(i) a dopamine active transporter (DAT) targeting agent comprising a dopamine re-uptake inhibitor (DRI) or an anti-DAT antibody; and (ii) a neurotrophin,
wherein the DAT targeting agent and neurotrophin are linked to a clathrin nanoparticle.
2 . The method of claim 1 , wherein the dopamine disorder is a neurodegenerative disease associated with loss of dopaminergic neurons.
3 . The method of claim 2 , wherein the neurodegenerative disease associated with loss of dopaminergic neurons is Parkinson's disease, Huntington's disease, Alzheimer's disease, or ALS.
4 . The method of claim 1 , wherein the dopamine disorder is ADHD, depression, or schizophrenia.
5 . The method of claim 1 , wherein the dopamine disorder is a dopamine-driven addiction.
6 . The method of claim 1 , wherein the composition is delivered intranasally or intravenously.