IP Library › Granted Patent US 12,502,431
Granted Patent B2
US 12,502,431 · App. 18/820,609 · Granted Dec 23, 2025

Delivery and formulation of engineered nucleic acids

Inventors: Antonin De Fougerolles (Waterloo, BE); Sayda M. Elbashir (Cambridge, MA)
Assignee: ModernaTX, Inc.
A61K47/18A61K31/7088A61K31/7115A61K38/193A61K38/4846A61K47/22A61K47/28C07K14/535C12N9/644C12N15/67C12N15/87A61K48/00C12N2310/335
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Quick Facts
Patent No.
US 12,502,431
App. No.
18/820,609
Granted
Dec 23, 2025
Kind
B2
Abstract

Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.

Claims (1)

1 . An aqueous solution comprising: (i) DNA encoding a protein of interest, (ii) nucleoside triphosphates consisting of guanosine triphosphate, adenosine triphosphate, cytidine triphosphate, and N1-methyl-pseudouridine triphosphate, and (iii) messenger RNA (mRNA) comprising an open reading frame comprising nucleosides consisting of N1-methyl-pseudouridine, adenosine, guanosine, and cytidine, and (iv) an RNA polymerase.

Assignments (3)
SECURITY INTEREST Recorded Nov 19, 2025
From: MODERNATX, INC.
To: ARES CAPITAL CORPORATION, AS AGENT
Reel/Frame 073634/0354 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 28, 2025
From: DE FOUGEROLLES, ANTONIN; ELBASHIR, SAYDA M.
To: MODERNA THERAPEUTICS, INC.
Reel/Frame 070362/0506 →
CHANGE OF NAME Recorded Feb 28, 2025
From: MODERNA THERAPEUTICS, INC.
To: MODERNATX, INC.
Reel/Frame 070366/0659 →
Continuity (9)
Continuation 18417715 · Jan 19, 2024
Continuation 17141753 · Jan 5, 2021
Continuation 15927730 · Mar 21, 2018
Continuation 15379284 · Dec 14, 2016
Division 14337513 · Jul 22, 2014
Continuation 13897362 · May 18, 2013
Continuation 13437034 · Apr 2, 2012
Provisional Application 61470451 · Mar 31, 2011
Related Publication 20250090666A1 · Mar 20, 2025
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