Fast Acting Joint Health Composition and Use Thereof
The present disclosure is directed to a joint-health composition containing one or more anti-inflammatory compounds in a lipid matrix, which improves bioavailability and nutrient availability of the anti-inflammatory compound, as well as allow the release of the anti-inflammatory compound to be controlled over a period of time. The anti-inflammatory compound can include an extract or isolate from a natural source that inhibits one or more of: interleukin-1 expression, interleukin-6 expression, NF-kB expression, cyclooxygenase-2 (COX-2) expression, inducible nitric oxide synthase (iNOS) expression, 5-lipoxygenase biosynthesis, and tumor necrosis factor-α (TNF-α) expression.
1 . A joint health composition for improving one or more of joint health and inflammation, comprising:
lipid multiparticulate particles, and
an anti-inflammatory compound,
the lipid multiparticulate particles comprising a lipid matrix, wherein the anti-inflammatory compound is dispersed within the lipid matrix,
and wherein the anti-inflammatory compound comprises an extract or isolate from a natural source that inhibits one or more of: interleukin-1 expression, interleukin-6 expression, NF-kB expression, cyclooxygenase-2 (COX-2) expression, inducible nitric oxide synthase (iNOS) expression, 5-lipoxygenase biosynthesis, and tumor necrosis factor-α (TNF-α) expression.
2 . The composition as defined in claim 1 , wherein the anti-inflammatory compound comprises an extract and/or isolate obtained from Andrographis paniculate, Tamarind seed, green lipped mussel ( Perna canaliculus ), turmeric ( Curcuma longa ), stinging nettle ( Urtica dioica ), Cat's claw ( Uncaria tomentosa ), or bromelain.
3 . The composition as defined in claim 1 , wherein the anti-inflammatory compound is
(a) an andrographolide, and wherein the andrographolide is contained in the joint health composition in an amount from about 2.5 mg to about 200 mg, or
(b) a tamarind seed extract, and wherein the tamarind seed extract is contained in the joint health compostions in an amount from about 10 mg to about 200 mg.
4 . (canceled)
5 . The composition as defined in claim 1 , wherein the joint health composition contains a total amount of the anti-inflammatory compound of about 200 mg or less.
6 . The composition as defined in claim 1 , wherein the anti-inflammatory compound is released from the composition over a period up to about 30 hours after ingestion by a mammal.
7 . The composition as defined in claim 1 , wherein the anti-inflammatory compound is encapsulated by the lipid matrix.
8 . The composition as defined in claim 1 , wherein the anti-inflammatory compound is present in the lipid multiparticulate particles in an amount from about 1% to about 80% by weight based on a total weight of the lipid multiparticulate particles.
9 . The composition as defined in claim 1 , wherein the joint-health composition is in a form of a capsule, a tablet, a powder, or is suspended in a liquid.
10 . The composition as defined in claim 1 , wherein the lipid multiparticulate particles have an average particle size of from about 40 microns to about 3000 microns.
11 . A method of improving one or more of joint pain and inflammation in a mammal, comprising:
supplying to the mammal a therapeutically effective amount of a joint-health composition comprising at least one anti-inflammatory compound dispersed within a lipid matrix of a lipid multiparticulate; and
wherein the anti-inflammatory compound comprises an extract or isolate from a natural source that inhibits one or more of: interleukin-1 expression, interleukin-6 expression, NF-kB expression, cyclooxygenase-2 (COX-2) expression, inducible nitric oxide synthase (iNOS) expression, 5-lipoxygenase biosynthesis, and tumor necrosis factor-α (TNF-α) expression.
12 . The method of claim 11 , wherein each dosage administered to the mammal contains the anti-inflammatory compound in an amount from about 1 mg to about 1,000 mg.
13 . The method as defined in claim 11 , wherein the composition is formulated such that the anti-inflammatory compound is released from the composition in period of time from about 0.5 hours to 24 hours after administration to a mammal.
14 . A method as defined in claim 11 , wherein the anti-inflammatory compound comprises an extract and/or isolate obtained from Andrographis paniculate, Tamarind seed, green lipped mussel ( Perna canaliculus ), turmeric ( Curcuma longa ), stinging nettle ( Urtica dioica ), Cat's claw ( Uncaria tomentosa ), or bromelain.
15 . The method as defined in claim 11 , wherein the anti-inflammatory compound is a tamarind seed extract (TSE), an andrographolide, or combinations or derivatives thereof.
16 . The method as defined in claim 11 , wherein the improvement in one or more of joint pain and inflammation is evidenced by a 10% or greater decrease in serum interleukin-1, interleukin-6, TNF-α, COX-2, SOX-9, MMP-13, or a combination thereof, or a subjective reduction in one or more of joint pain and inflammation, in about two weeks or less.
17 . The method as defined in claim 11 , wherein the improvement in one or more of joint pain and inflammation is evidenced in about one week or less.
18 . The method as defined in claim 11 , wherein the improvement in one or more of joint pain and inflammation is evidenced by a decrease in serum: interleukin-1, interleukin-6, TNF-α, COX-2, SOX-9, MMP-13, or a combination thereof of at least about 15%, after 10 days or less.
19 . The method as defined in claim 11 , wherein improvement in one or more of joint pain and inflammation is evidenced by a decrease in
(a) interleukin-1 serum of at least about 20%,
(b) interleukin-6 serum of at least about 20%, or
(c) matrix metallopeptidase 13 serum of at least about 20%.
20 . (canceled)
21 . (canceled)
22 . The method as defined in claim 11 , wherein the joint health composition is administered to the mammal in a therapeutically effective amount sufficient to change a Kellgren-Lawrence score of the mammal by at least about 20%.
23 . The method as defined in claim 11 , wherein the joint health composition administered daily.
24 . A method of reducing inflammation in a mammal, the method comprising providing the joint-health composition of claim 1 and administering the joint-health composition to the mammal in need of a reduction in inflammation.
25 . A method of increasing bioavailability of an anti-inflammatory compound in a mammal, wherein the method comprises forming a joint-health composition according to claim 1 and administering the joint-health composition to the mammal.