SCLAREOL OR SCLAREOLIDE FOR IMPROVING SCALP CONDITIONS AND HAIR GROWTH
The present disclosure relates to the field of personal care and more particularly to a method for improving scalp condition and hair growth, which comprises applying to the scalp a composition comprising an active agent selected among sclareol, sclareol-like, sclareolide or sclareolide-like and a physiologically acceptable carrier
1 . A method for improving the scalp condition and hair growth which comprises applying to the scalp a composition comprising an active agent selected among sclareol, sclareol-like, sclareolide or sclareolide-like and a physiologically acceptable carrier.
2 . The method of claim 1 wherein improving the scalp condition is chosen among at least one of the following scalp conditions: improvement of scalp hydration, decrease of scalp sebum, improvement of scalp pH, decrease in scalp sensitivity (itching) and reinforcement of skin barrier function.
3 . The method of claim 1 which is a method for eliminating or reducing dandruff.
4 . The method of claim 1 which is a method for decreasing the growth of Malassezia species.
5 . The method of claim 1 which is a method for decreasing the growth of Malassezia species, wherein Malassezia species is Malassezia restricta or Malassezia furfur.
6 . The method of claim 1 wherein the composition comprises an active agent selected among sclareol, sclareol-like, sclareolide or sclareolide-like in a concentration ranging from 0.01% to 2.0% by weight, relative to the total weight of the composition.
7 . The method of claim 1 wherein the composition is in the form of a rinse off formula and comprises the sclareolide as an active agent in a concentration up to 0.5% by weight, relative to the total weight of the composition.
8 . The method of claim 1 wherein the composition comprises sclareolide in a concentration ranging from 0.001% to 0.2% by weight, relative to the total weight of the composition.
9 . The method of claim 1 wherein the composition is applied for at least 14 days.
10 . The method of claim 1 for improving hair growth, wherein the composition comprises 0.12% sclareolide.
11 . The method of claim 1 wherein the level of the enzyme CYP27B1 is increased.
12 . The method of claim 1 wherein keratin 10 expression and total lipid content are increased.
13 . The method of claim 1 wherein the composition is suitable for topical application.
14 . The method of claim 1 wherein the composition is in the form of a liquid, a lotion, an aerosol, a cream, a gel, an ointment, a rinse off formula or a shampoo.
15 . The method of claim 1 , wherein the composition is in the form of a shampoo and wherein the solubility of the sclareolide is enhanced by using an encapsulation system or a surfactant soluble solubilizer.