OXYSTEROLS AND METHODS OF USE THEREOF
Compounds are provided according to Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein X, Y, R 1 , R 2a , R 2b , R 4a , R 4b , R 5a , R 5b , R 6a , R 6b , R 7 , and R 8 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
1 .- 36 . (canceled)
37 . A method of inducing sedation or anesthesia comprising administering to a subject an effective amount of a compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
38 .- 41 . (canceled)
42 . A method for treating a CNS-related condition comprising administering to a subject in need thereof an effective amount of a compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
43 . The method according to claim 42 , wherein the CNS-related condition is an adjustment disorder, anxiety disorder, cognitive disorder, dissociative disorder, eating disorder, mood disorder, schizophrenia or other psychotic disorder, sleep disorder, substance-related disorder, personality disorder, autism spectrum disorders, neurodevelopmental disorder, multiple sclerosis, sterol synthesis disorders, pain, encephalopathy secondary to a medical condition, seizure disorder, stroke, traumatic brain injury, movement disorder, vision impairment, hearing loss, and tinnitus.
44 . (canceled)
45 . The method of claim 43 , wherein the CNS-related condition is schizophrenia.
46 . The method of claim 43 , wherein the CNS-related condition is anti-NMDA receptor encephalitis.
47 . The method of claim 43 , wherein the CNS-related condition is stroke.
48 . The method of claim 43 , wherein the CNS-related condition is Alzheimer's disease or dementia.
49 . The method of claim 43 , wherein the CNS-related condition is Huntington's disease.
50 . The method of claim 43 , wherein the CNS-related condition is Parkinson's disease.
51 . The method of claim 37 , wherein the compound is selected from the group consisting of.
52 . The method of claim 42 , wherein the compound is selected from the group consisting of:
53 . The method according to claim 43 , wherein the compound is selected from the group consisting of:
54 . A compound selected from the group consisting of