Preservatives for Cosmetic, Toiletry and Pharmaceutical Compositions
A composition for and methods of preserving a topical cosmetic, toiletry or pharmaceutical formulation against microbiological contamination or growth are described in which the compositions used herein include at least one hydroxamic acid, salt or complex thereof, and the methods include addition of an effective amount of such compounds to a cosmetic, toiletry or pharmaceutical formulation. Compositions further including alkanediols and/or solubilizing agents in blends with hydroxamic acid are also described.
1 .- 20 . (canceled)
21 . A composition for the preservation of topical cosmetic, toiletry and pharmaceutical formulations, consisting of caprylohydroxamic acid or a salt and/or a complex thereof, and caprylyl glycol, and optionally glycerin or one or more glycols or vicinal diols that are liquid at room temperature.
22 . The composition of claim 21 , wherein the composition consists of caprylohydroxamic acid or a salt and/or a complex thereof, and caprylyl glycol, and the one or more glycols or vicinal diols.
23 . The composition of claim 22 , wherein the one or more glycols or vicinal diols is selected from ethylhexylglycerin, 1,2-hexanediol, 1,2-pentanediol, propylene glycol, butylene glycol, and hexylene glycol.
24 . The composition of claim 22 , wherein the one or more glycols or vicinal diols is a propanediol.
25 . The composition of claim 21 , wherein the composition consists of caprylohydroxamic acid or a salt and/or a complex thereof, and caprylyl glycol, and glycerin.
26 . The composition of claim 21 , wherein the composition is free of parabens.
27 . A composition for the preservation of topical cosmetic, toiletry and pharmaceutical formulations, consisting of a blend of three components which are caprylohydroxamic acid or a salt and/or a complex thereof, one vicinal diol, and a solvent, and wherein the composition is free of parabens.
28 . The composition of claim 27 , wherein the vicinal diol is selected from the group consisting of: 1,2-pentanediol, 1,2-hexanediol, caprylyl glycol, 1,2-decanediol, ethylhexylglycerin, glyceryl monolaurate, glyceryl monocaprate, glyceryl mono caproate, and glyceryl monocaprylate.
29 . The composition of claim 28 , wherein the solvent is glycerin, or an additional glycol or vicinal diol that is liquid at room temperature, and is included in an amount of from 1% to 70% by weight of the blend, based on the total weight of the blend.
30 . The composition of claim 29 , wherein the solvent is glycerin.
31 . The composition of claim 29 , wherein the solvent is the additional glycol or vicinal diol.
32 . The composition of claim 31 , wherein the additional glycol or vicinal diol is selected from propylene glycol, butylene glycol, and a propanediol.
33 . The composition of claim 32 , wherein the additional glycol or vicinal diol is methylpropanediol.
34 . A composition for the preservation of topical cosmetic, toiletry and pharmaceutical formulations, consisting of caprylohydroxamic acid or a salt and/or a complex thereof, and at least one vicinal diol, and optionally a solubilizing agent in an amount of from about 1% to about 70% by weight of the hydroxamic acid/alcohol blend.
35 . The composition of claim 34 , wherein the at least one vicinal diol is selected from the group consisting of: 1,2-pentanediol, 1,2-hexanediol, caprylyl glycol, 1,2-decanediol, ethylhexylglycerin, glyceryl monolaurate, glyceryl monocaprate, glyceryl mono caproate, and glyceryl monocaprylate.
36 . The composition of claim 35 , wherein the solubilizing agent is present and is a diol or glycerin.
37 . The composition of claim 36 , wherein the solubilizing agent is glycerin.
38 . The composition of claim 36 , wherein the solubilizing agent is a diol and is selected from propylene glycol, butylene glycol, and a propanediol.
39 . The composition of claim 38 , wherein the solubilizing agent is methylpropanediol.
40 . The composition of claim 34 , wherein the composition is free of parabens.