SYSTEMS, DEVICES, AND METHODS FOR FLUID CONTROL IN A CELL PROCESSING SYSTEM
The present disclosure relates to systems, devices, and methods for controlling fluid flow within a cell processing system. In an embodiment, the present disclosure relates to a device having a rotor comprising one or more rollers configured to compress a first fluid conduit, a first lever arm defining a proximal portion and a distal portion, where the first lever arm comprises a first hinge at the proximal portion, and a second hinge in between the proximal portion and the distal portion, a spring coupled to the distal portion, and a second lever arm, where the first and second lever arms are aligned with the rotor and are configured to receive the first fluid conduit.
1 . A method of controlling fluid flow comprising:
providing fluid to a first fluid conduit of a pump assembly, the pump assembly further comprising a lever arm and a rotor operatively coupled to a pump motor, wherein the rotor comprises one or more rollers configured to compress the first fluid conduit;
pumping the fluid through the first fluid conduit via rotation of the rotor;
measuring one or more of a torque value and a rotor position value; and
modifying the rotation of the rotor based on the one or more measurements to modify fluid flow through the first fluid conduit.
2 . The method of claim 1 further comprising measuring one or more of a motor power value, a motor current value, a sensor distance value, and a pressure value.
3 . The method of claim 1 , wherein the rotor rotates at a rate between about 1 rpm and about 20 rpm.
4 . The method of claim 1 further comprising using an empirical model to estimate a flow rate of the fluid flow through the first fluid conduit.
5 . The method of claim 1 , wherein modifying the rotation of the rotor is performed in a closed loop.
6 . The method of claim 1 , wherein modifying the rotation of the rotor is performed in an open loop.
7 . The method of claim 1 further comprising providing fluid to a second fluid conduit of the pump assembly.
8 . The method of claim 7 further comprising maintaining a non-zero flow rate through one or more of the first fluid conduit and the second fluid conduit.
9 . A device for pumping fluid, comprising:
a rotor comprising one or more rollers configured to compress a first fluid conduit;
a first lever arm defining a proximal portion and a distal portion, wherein the first lever arm comprises a first hinge at the proximal portion, and a second hinge in between the proximal portion and the distal portion;
a spring coupled to the distal portion; and
a second lever arm, wherein the first and second lever arms are aligned with the rotor and are configured to receive the first fluid conduit.
10 . The device of claim 9 , wherein the second lever arm is coupled to the second hinge.
11 . The device of claim 9 , wherein the second hinge is positioned equidistantly between the proximal portion and the distal portion.
12 . The device of claim 9 , wherein the second lever arm is configured to rotate relative to the first lever arm.
13 . The device of claim 9 , wherein the one or more rollers comprises at least three rollers.
14 . The device of claim 9 , wherein the one or more rollers comprises at least five rollers.
15 . The device of claim 9 , wherein the one or more rollers comprises between six and ten rollers.
16 . The device of claim 9 further comprising a motor operatively coupled to the rotor.
17 . The device of claim 16 , wherein the motor is configured to rotate the rotor up to about 20 rotations per minute.
18 . The device of claim 16 , wherein the motor is configured to rotate the rotor between about 10 rotations per minute and about 30 rotations per minute.
19 . The device of claim 9 further comprising one or more sensors operatively coupled to the rotor.
20 . The device of claim 9 further comprising a controller for controlling the rotor.
21 . The device of claim 9 , wherein the spring comprises a spring force between about 20 N and about 30 N.
22 . The device of claim 9 further comprising a second rotor comprising one or more rollers configured to compress a second fluid conduit.
23 . A closed-loop fluid pump comprising:
a fluid conduit;
a rotor comprising one or more rollers configured to compress the fluid conduit upon rotation of the rotor;
a first lever arm and a second lever arm, wherein at least one of the first and second lever arms comprises at least two hinges;
a spring coupled to at least one of the first and second lever arms;
a flow sensor configured to measure the flow rate through the fluid conduit; and
a controller configured to modify the rotation of the rotor based on the flow rate measurement.
24 . The fluid pump of claim 23 , wherein the second lever arm is configured to rotate relative to the first lever arm.
25 . The fluid pump of claim 23 , wherein the one or more rollers comprises at least three rollers.
26 . The fluid pump of claim 23 , wherein the one or more rollers comprises at least five rollers.
27 . The fluid pump of claim 23 , wherein the one or more rollers comprises between six and ten rollers.
28 . The fluid pump of claim 23 further comprising a motor operatively coupled to the rotor.
29 . The fluid pump of claim 28 , wherein the motor is configured to rotate the rotor up to about 20 rotations per minute.
30 . The fluid pump of claim 28 , wherein the motor is configured to rotate the rotor between about 10 rotations per minute and about 30 rotations per minute.
31 .- 34 . (canceled)