IP Library › Granted Patent US 12,529,058
Granted Patent B2
US 12,529,058 · App. 18/931,989 · Granted Jan 20, 2026

Composition for regulating production of interfering ribonucleic acid

Inventor: Bradley G. Thompson (Calgary, CA)
Assignee: Wyvern Pharmaceuticals Inc.
C12N15/1137C12N15/86C12N2310/141C12N2750/14143C12Y207/01
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Quick Facts
Patent No.
US 12,529,058
App. No.
18/931,989
Granted
Jan 20, 2026
Kind
B2
Abstract

The embodiments of the present disclosure relate to decreasing the bioavailability of one or more target biomolecules by providing a composition that comprises a recombinant plasmid with one or more sequences of micro interfering ribonucleic acid (miRNA). When the recombinant plasmid interacts with a target cell, it causes the target cell to upregulate production of the miRNA, which then decreases the bioavailability of the target biomolecule. In some embodiments of the present disclosure, the target biomolecule is a kinase.

Claims (4)

1 . A composition that comprises a recombinant plasmid (RP) comprising a sequence of nucleotides that is SEQ ID NO: 4.

2 . The composition of claim 1 , wherein the RP is encapsulated in a protein coat, a lipid vesicle, or any combination thereof.

3 . A composition that comprises a recombinant plasmid (RP) comprising a sequence of nucleotides that is SEQ ID NO: 12.

4 . The composition of claim 3 , wherein the RP is encapsulated in a protein coat, a lipid vesicle, or any combination thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 20, 2025
From: THOPSON, BRADLEY G.
To: WYVERN PHARMACEUTICALS INC.
Reel/Frame 072073/0434 →
Continuity (2)
Division 18518069 · Nov 22, 2023
Related Publication 20250163424A1 · May 22, 2025
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