CARBAMOYL PHENYLALANINOL COMPOUNDS AND USES THEREOF

1 . A method of treating nightmares and/or sleep-related disturbances associated with PTSD in a subject in need thereof, comprising administering to the subject a compound of Formula II:

wherein

R is optionally substituted lower alkyl of 1 to 8 carbon atoms, halogen, optionally substituted alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, cyano, trifluoromethyl, or optionally substituted thioalkoxy containing 1 to 3 carbon atoms;

x is an integer of 0 to 3, with the proviso that R may be the same or different when x is 2 or 3;

R 1 , R 2 , and R 3 are independently hydrogen, optionally substituted lower alkyl of 1 to 8 carbon atoms, optionally substituted aryl, optionally substituted arylalkyl, or optionally substituted cycloalkyl of 3 to 7 carbon atoms; or

R 2 and R 3 can be joined to form a 5 to 7-membered heterocycle optionally substituted with a member selected from the group consisting of alkyl and aryl groups, wherein the heterocycle can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom;

or a pharmaceutically acceptable salt thereof.

2 . The method of claim 1 , wherein the compound is compound 2:

or a pharmaceutically acceptable salt thereof.

3 . The method of claim 1 , comprising administering a composition comprising the compound.

4 . The method of claim 1 , comprising administering a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier.

5 . The method of claim 4 , wherein the composition is a dosage form.

6 . The method of claim 5 , wherein the composition is an immediate release oral dosage form.

7 . The method of claim 6 , wherein the composition is a tablet or a capsule.