IP Library › Patent Application 18954799
Patent Application
App. No. 18/954,799

PIM KINASE INHIBITORS FOR TREATMENT OF MYELOPROLIFERATIVE NEOPLASMS AND FIBROSIS ASSOCIATED WITH CANCER

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Quick Facts
Patent No.
US None
App. No.
18/954,799
Abstract

Methods for treatment of myeloproliferative neoplasms and/or fibrosis associated with cancer are provided. The disclosed methods comprise administering a PIM kinase inhibitor, and optionally a JAK kinase inhibitor or other therapeutic agent, to a mammal in need thereof.

Claims (4)

1 . A method for treating a myeloproliferative neoplasm in a mammal in need thereof, the method comprising administering to the mammal:

from about 250 mg to about 2.5 g per day of a compound represented by the following structural formula:

or a pharmaceutically acceptable salt thereof; and

an effective amount of ruxolitinib, or a pharmaceutically acceptable salt thereof.