INSULIN FORMULATIONS AND USES IN INFUSION DEVICES
Embodiments of the present disclosure provide insulin formulations having a near neutral pH and improved pharmacokinetic/pharmacodynamic properties, and uses in insulin infusion devices that may provide extended infusion period up to 7-14 days. Also provided are systems for administering insulin, the system may include a first reservoir, a second reservoir, an insulin pump configured to administer contents of the first reservoir or the second reservoir, and one or more hardware processors in communication with the insulin pump.
1 . (canceled)
2 . An insulin administration device comprising:
a first reservoir comprising insulin;
a second reservoir comprising a hyaluronidase;
an insulin pump configured to administer contents of the first reservoir and second reservoir to a subject; and
one or more hardware processors in communication with the insulin pump, the one or more hardware processors configured to:
receive a signal from a sensor indicative of a blood glucose concentration of the subject;
determine, based on the blood glucose concentration and a desired insulin response speed of the subject, a first infusion amount of insulin and a second infusion amount of hyaluronidase, wherein a volumetric ratio of the first infusion amount and second infusion amount is tunable to achieve a particular pharmacokinetic or pharmacodynamic response from the subject; and
administer, using the insulin pump, the first infusion amount and the second infusion amount.
3 . The insulin administration device of claim 2 , wherein the first infusion amount and the second infusion amount are administered simultaneously.
4 . The insulin administration device of claim 2 , wherein the first infusion amount and the second infusion amount are administered sequentially.
5 . The insulin administration device of claim 2 , wherein one or both the first or the second reservoir further comprises one or more insulin dissolution agents.
6 . The insulin administration device of claim 5 , wherein the insulin dissolution agents comprise citric acid, a salt, or a substituted derivative thereof; oligosaccharides; or combinations thereof.
7 . The insulin administration device of claim 2 , wherein the insulin is a slow-acting insulin, a fast-acting insulin, or is in the form of a hexamer, and wherein the insulin in the first reservoir has a concentration of at least 100 U/mL.
8 . The insulin administration device of claim 2 , further comprising an administration mechanism configured to deliver the insulin from the first reservoir to a subject.
9 . The insulin administration device of claim 8 , wherein the administration mechanism comprises a cannula or a syringe.
10 . The insulin administration device of claim 8 , wherein the administration mechanism is coated with one or more anti-platelet agents, one or more anti-thrombosis agents, or one or more cell self markers, or combination thereof.
11 . An insulin administration device comprising:
a first reservoir comprising insulin;
a second reservoir comprising an insulin adjunctive excipient, the insulin adjunctive excipient comprising one or more of a hyaluronidases, an insulin dissolution agent, an anti-platelet agents, an anti-thrombosis agents, a cell self marker, glucagon, a glucagon activating agent, an insulin inhibiting agents, or combinations thereof;
an insulin pump configured to administer contents of the first reservoir and second reservoir to a subject; and
one or more hardware processors in communication with the insulin pump, the one or more hardware processors configured to:
receive a signal from a sensor indicative of a blood glucose concentration of the subject;
determine, based on the blood glucose concentration and a desired insulin response speed of the subject, a first infusion amount of insulin and a second infusion amount of insulin adjunctive excipient, wherein a volumetric ratio of the first infusion amount and second infusion amount is tunable to achieve a particular pharmacokinetic/pharmacodynamic response from the subject; and
administer, using the insulin pump, the first infusion amount and the second infusion amount.
12 . The insulin administration device of claim 11 , wherein the first infusion amount and the second infusion amount are administered simultaneously.
13 . The insulin administration device of claim 11 , wherein the first infusion amount and the second infusion amount are administered sequentially.
14 . The insulin administration device of claim 11 , wherein the insulin is a slow-acting insulin, a fast-acting insulin, or is in the form of a hexamer, and wherein the insulin in the first reservoir has a concentration of at least 100 U/mL.
15 . The insulin administration device of claim 11 , further comprising an administration mechanism configured to deliver the insulin from the first reservoir to a subject.
16 . The insulin administration device of claim 15 , wherein the administration mechanism comprises a cannula or a syringe.
17 . The insulin administration device of claim 15 , wherein the administration mechanism is coated with one or more anti-platelet agents, one or more anti-thrombosis agents, or one or more cell self markers, or combination thereof.
18 . A method of administering insulin, the method comprising:
receiving from a glucose sensor a blood glucose concentration of a subject;
determining a desired insulin response speed based at least in part on the blood glucose concentration;
determining, based at least on the desired insulin response speed, a dosage comprising a first infusion amount of insulin and a second infusion amount comprising a hyaluronidase, wherein a volumetric ratio of the first infusion amount and second infusion amount is tunable to achieve a particular pharmacokinetic/pharmacodynamic response from the subject; and
administering, using an insulin pump in fluid communication with a first reservoir comprising insulin and a second reservoir comprising the hyaluronidase, the dosage to the subject.
19 . The method of claim 18 , wherein the administering of the first infusion amount and the second infusion amount is simultaneous.
20 . The method of claim 18 , wherein the administering of the first infusion amount and the second infusion amount is sequential.
21 . The method of claim 18 , wherein the insulin has a pH between about 6.8 and about 7.4.