USE OF AMISULPRIDE AS AN ANTI-EMETIC
Amisulpride is used in the therapy of nausea, vomiting or retches. The therapy may utilize a novel injectable formulation, in unit dosage form, comprising less than 50 mg amisulpride.
1 . A method for the prevention and/or treatment of post-operative nausea and vomiting, comprising administering amisulpride at a dose of 1 mg to 35 mg to a human subject of a surgical procedure and in need of such prevention and/or treatment, wherein the amisulpride is administered in combination with another anti-emetic drug.
2 . The method according to claim 1 , wherein the human subject is also administered an emetogenic agent.
3 . The method according to claim 2 , wherein the emetogenic agent is an opiate.
4 . The method according to claim 2 , wherein the emetogenic agent is morphine.
5 . The method according to claim 1 , wherein the human subject is also administered an anesthetic.
6 . The method according to claim 1 , wherein the other anti-emetic drug administered in combination with the amisulpride is a 5HT3 antagonist, an NK1 antagonist, or a steroid.
7 . The method of claim 6 , wherein the other anti-emetic administered in combination with the amisulpride is dexamethasone, ondansetron, granisetron, palonosetron, aprepitant, netupitant, or rolapitant.
8 . The method according to claim 6 , wherein the 5HT3 antagonist is ondansetron.
9 . The method of claim 1 , wherein the amisulpride is administered in the form of a pharmaceutical composition comprising amisulpride, citric acid monohydrate, trisodium citrate dihydrate, and sodium chloride.
10 . The method of claim 9 , wherein the pharmaceutical composition comprises 0.25% w/v amisulpride.
11 . The method of claim 9 , wherein the pharmaceutical composition comprises 0.25% w/v amisulpride, 0.935% w/v citric acid monohydrate, 1.632% w/v trisodium citrate dihydrate, and 0.18% w/v sodium chloride.
12 . The method of claim 1 , wherein the amisulpride is S-amisulpride.
13 . The method of claim 1 , wherein the amisulpride is administered intravenously.
14 . The method of claim 1 , for the prevention of post-operative nausea and vomiting.
15 . The method of claim 1 , for the treatment of post-operative nausea and vomiting.