Orally Available Albenatide
Orally administrable pharmaceutical compositions comprising an incretin or analog or derivative thereof are presented that allow for extended control of blood glucose. Formulations presented herein comprise a self-emulsifying drug delivery system (SEDDS). Advantageously such formulations afford protection from the proteolytic conditions in the upper gastrointestinal tract while allowing for effective drug release and absorption in the lower gastrointestinal tract.
1 . A pharmaceutical composition, comprising:
a hydrophobic ion pair complex comprising a hydrophobic ionic agent that is non-covalently coupled to an incretin or fragment or analog thereof;
wherein the hydrophobic ion pair complex is encapsulated in an emulsion of a self-emulsifying drug delivery system (SEDDS) or a SEDDS preconcentrate.
2 . The composition of claim 1 , wherein the incretin is a Class B G-protein coupled receptor (GPCR) agonist.
3 . The composition of claim 1 , wherein the incretin is a GLP-1 agonist, a GIP agonist, a GcG agonist, a NPY2 agonist, a Y2 agonist, or a PYY agonist.
4 . The composition of claim 1 , wherein the incretin is CJC-1134 (SEQ ID NO:1).
5 . The composition of claim 1 , wherein the hydrophobic ionic agent is an anionic agent.
6 . The composition of claim 5 , wherein the hydrophobic ionic agent is docusate.
7 . The composition of claim 1 , wherein the SEDDS comprises n-methyl pyrrolidone, a glycol, a polyethoxylated castor oil, a mono- and/or diglyceride of a medium chain (C6-C8) fatty acid, and a non-ionic surfactant composed of a mixture of glycerides and fatty acid esters.
8 . The composition of claim 1 , wherein the hydrophobic ion pair complex is encapsulated in a preconcentrate.
9 . The composition of claim 1 , wherein the SEDDS or the SEDDS preconcentrate is adsorbed onto a solid carrier.
10 . The composition of claim 9 , wherein the composition is prepared in a unit dosage form that provides between 100 and 1,000 mg of the SEDDS or the SEDDS preconcentrate per unit dosage.
11 . The composition of claim 9 , wherein the composition is prepared in a unit dosage form that, upon oral administration to a mammal reduces blood glucose by at least 10% over at least 6 hours.
12 . A method of reducing blood glucose in a mammal, comprising:
orally administering the pharmaceutical composition of claim 1 to the mammal at a dosage effective to reduce the blood glucose in the mammal.
13 . The method of claim 1 , wherein the pharmaceutical composition is formulated as a tablet or as a preconcentrate.
14 . The method of claim 1 , wherein the pharmaceutical composition is formulated in a unit dose that provides between 100 and 1,000 mg of the SEDDS or the SEDDS preconcentrate per unit dosage.
15 . The method of claim 1 , wherein the blood glucose is reduced by at least 10% over a time period of at least 6 hours.
16 . The method of claim 1 , wherein oral administration reduces HbA1c by at least 0.5% (absolute) when administered over at least 8 weeks.
17 . The method of claim 1 , wherein administration is once daily.
18 . A pharmaceutical composition, comprising:
an incretin or fragment or analog thereof, optionally covalently bound to a carrier protein;
wherein the incretin or fragment or analog thereof is encapsulated in a pheroid drug delivery system.
19 . The composition of claim 18 , wherein the incretin or fragment or analog thereof is CJC-1134.
20 . The composition of claim 19 , wherein the CJC-1134 is covalently bound to a carrier protein, wherein the carrier protein is albumin.