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Patent Application

App. No. 18/990,148

4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF

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App. No.: 18/990,148

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Abstract

4-Alkoxypyrrolo[2,1-f][1,2,4]triazine compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 4-alkoxypyrrolo[2,1-f][1,2,4]triazine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, viral infections, and osteoarthritis).

Claims (1762)

1 . A compound, or a pharmaceutically acceptable salt thereof, of Formula I:

wherein:

R 1 is a 9-10 membered heteroaryl optionally substituted with 1-10 R 5 ;

R 2 is selected from the group consisting of —(C 1-5 alkylene)CN, -heterocyclyl optionally substituted with 1-10 R 6 , —(C 1-2 alkylene)C(═O)heterocyclyl, and -carbocyclyl optionally substituted with 1-12 R 7 , wherein the —(C 1-2 alkylene) or (C 1-5 alkylene) is optionally substituted with 1-2 halide and/or 1-2 unsubstituted —(C 1-3 alkyl);

R 3 is unsubstituted —(C 1-3 alkyl);

R 4 is selected from the group consisting of H and halide;

each R 5 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 1-9 haloalkyl), —(C 1-4 alkylene)OH, -carbocyclyl optionally substituted with 1-12 halides, —C(═O)N(R 8 ) 2 , wherein the —(C 1-4 alkylene) is optionally substituted with 1-4 halide and/or 1-2 unsubstituted —(C 1-3 alkyl);

each R 6 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted -heterocyclyl, —(C 1-3 alkylene)OR 9 , —SO 2 Me, and —(C 1-3 alkylene) p C(═O)R 10 , wherein each —(C 1-3 alkylene) is, independently, optionally substituted with 1-2 halide and/or 1-2 unsubstituted —(C 1-3 alkyl);

alternatively, two R 6 attached to the same carbon atom are taken together to form a carbonyl group;

each R 7 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), —OH, and —NHC(═O)R 1 ;

each R 8 is independently selected from the group consisting of H, unsubstituted —(C 1-9 alkyl), and unsubstituted —(C 1-9 haloalkyl);

each R 9 is independently selected from the group consisting of H and unsubstituted —(C 1-9 alkyl);

each R 10 is independently selected from the group consisting of unsubstituted —(C 1-9 alkyl), —(C 1-2 alkylene) p N(R 12 ) 2 , —(C 1-2 alkylene)OR 9 , —(C 1-2 alkylene) p heterocyclyl, and unsubstituted -carbocyclyl, wherein each —(C 1-2 alkylene) is, independently, optionally substituted with 1-2 halide and/or 1-2 unsubstituted —(C 1-3 alkyl);

each R 11 is independently selected from the group consisting of unsubstituted —(C 1-9 alkyl), —(C 1-2 alkylene) p OR 9 , and -carbocyclyl optionally substituted with 1-12 halides, wherein the —(C 1-2 alkylene) is optionally substituted with 1-2 halide and/or 1-2 unsubstituted —(C 1-3 alkyl);

each R 12 is independently selected from the group consisting of H and unsubstituted —(C 1-9 alkyl);

each p is independently 0 or 1; and

wherein each H atom is optionally, independently replaced by 2 H (D) (deuterium).

2 . The compound of claim 1 , wherein R 1 is selected from the group consisting of

optionally substituted with 1-10 R 5 .

3 . The compound of claim 2 , wherein R 1 is selected from the group consisting of

optionally substituted with 1-3 R 5 .

4 . The compound of claim 3 , wherein R 1 is selected from the group consisting of

optionally substituted with 1-3 R 5 .

5 . The compound of claim 4 , wherein R 1 is selected from the group consisting of

optionally substituted with 1-3 R 5 .

6 . The compound of claim 1 , wherein each R 5 is independently selected from the group consisting of F, unsubstituted —(C 1-3 alkyl), unsubstituted —(C 1-3 haloalkyl), —(C 1-3 alkylene)OH, -carbocyclyl optionally substituted with 1-4 fluorines, —C(═O)N(R 8 ) 2 , wherein the —(C 1-3 alkylene) is optionally substituted with 1-2 halide.

7 . The compound of claim 5 , wherein each R 5 is independently selected from the group consisting of F, unsubstituted —(C 1-3 alkyl), unsubstituted —(C 1-3 haloalkyl), —(C 1-3 alkylene)OH, -carbocyclyl optionally substituted with 1-4 fluorines, —C(═O)N(R 8 ) 2 , wherein the —(C 1-3 alkylene) is optionally substituted with 1-2 halide.

8 . The compound of claim 6 , wherein R 2 is selected from the group consisting of —(C 2 -4 alkylene)CN, -heterocyclyl optionally substituted with 1-4 R 6 , —CH 2 C(═O)heterocyclyl, and -carbocyclyl optionally substituted with 4 R 7 , wherein the —(C 1-2 alkylene) or (C 2-4 alkylene) is optionally substituted with 1-2 halide.

9 . The compound of claim 7 , wherein R 2 is selected from the group consisting of —(C 2 -4 alkylene)CN, -heterocyclyl optionally substituted with 1-4 R 6 , —CH 2 C(═O)heterocyclyl, and -carbocyclyl optionally substituted with 4 R 7 , wherein the —(C 1-2 alkylene) or (C 2-4 alkylene) is optionally substituted with 1-2 halide.

10 . The compound of claim 8 , wherein R 3 is methyl.

11 . The compound of claim 9 , wherein R 3 is methyl.

12 . The compound of claim 1 , wherein R 4 is selected from the group consisting of H and F.

13 . The compound of claim 10 , wherein each R 6 is independently selected from the group consisting of F, unsubstituted —(C 1-3 alkyl), unsubstituted -heterocyclyl, —CH 2 CH 2 OH, —CH 2 CH 2 OMe, —SO 2 Me, and —(CH 2 ) p C(═O)R 10 .

14 . The compound of claim 11 , wherein each R 6 is independently selected from the group consisting of F, unsubstituted —(C 1-3 alkyl), unsubstituted -heterocyclyl, —CH 2 CH 2 OH, —CH 2 CH 2 OMe, —SO 2 Me, and —(CH 2 ) p C(═O)R 10 .

15 . The compound of claim 13 , wherein each R is independently selected from the group consisting of F, unsubstituted —(C 1-3 alkyl), —OH, and —NHC(═O)R 11 .

16 . The compound of claim 14 , wherein each R is independently selected from the group consisting of F, unsubstituted —(C 1-3 alkyl), —OH, and —NHC(═O)R 11 .

17 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

(R)-1-(3,3-difluoro-4-((4-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(pyrazolo[1,5-a]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [2];

5-(2-((2-cyano-2-methylpropyl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [3];

5-(2-((4,4-difluorocyclohexyl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [4];

5-(2-(((1r,4r)-4-hydroxy-4-methylcyclohexyl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-(methyl-d 3 )pyrazolo[1,5-a]pyridine-3-carboxamide [5];

N-ethyl-5-(2-(((1r,4r)-4-hydroxy-4-methylcyclohexyl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [6];

N-(2,2-difluoroethyl)-5-(2-(((1r,4r)-4-hydroxy-4-methylcyclohexyl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)pyrazolo[1,5-a]pyridine-3-carboxamide [7];

5-(2-(((1r,4r)-4-hydroxy-4-methylcyclohexyl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-isopropylpyrazolo[1,5-a]pyridine-3-carboxamide [8];

5-(2-(((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [9];

(R)-5-(2-((3,3-difluoro-1-methylpiperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [10];

(R)-5-(2-((1-acetyl-3,3-difluoropiperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [11];

(R)-5-(2-((3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [12];

5-(2-((2-cyano-2-methylpropyl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [13];

5-(2-((4,4-difluorocyclohexyl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [14];

(R)-5-(2-((4,4-difluoro-1-methylpyrrolidin-3-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [15];

(R)-5-(2-((4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [16];

5-(6-fluoro-4-methoxy-2-((1-(oxetan-3-yl)piperidin-4-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [17];

5-(6-fluoro-2-(((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [18];

5-(6-fluoro-2-(((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [19];

5-(6-fluoro-2-(((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [20];

5-(6-fluoro-2-(((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [21];

(R)-5-(2-((3,3-difluoro-1-methylpiperidin-4-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [22];

(R)-5-(2-((3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [23];

(R)-5-(2-((3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [24];

5-(2-((2-oxaspiro[3.5]nonan-7-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide [25];

5-(2-((2-cyano-2-methylpropyl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-isopropylpyrazolo[1,5-a]pyridine-3-carboxamide [26];

5-(2-((4,4-difluorocyclohexyl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-isopropylpyrazolo[1,5-a]pyridine-3-carboxamide [27];

5-(6-fluoro-2-(((1s,4s)-4-hydroxy-4-methylcyclohexyl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-isopropylpyrazolo[1,5-a]pyridine-3-carboxamide [28];

5-(6-fluoro-2-(((1r,4r)-4-hydroxy-4-methylcyclohexyl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-isopropylpyrazolo[1,5-a]pyridine-3-carboxamide [29];

(R)-5-(2-((4,4-difluoro-1-methylpyrrolidin-3-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-isopropylpyrazolo[1,5-a]pyridine-3-carboxamide [30];

(R)-5-(2-((4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-isopropylpyrazolo[1,5-a]pyridine-3-carboxamide [31];

5-(6-fluoro-4-methoxy-2-((1-(oxetan-3-yl)piperidin-4-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-isopropylpyrazolo[1,5-a]pyridine-3-carboxamide [32];

5-(6-fluoro-2-(((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-isopropylpyrazolo[1,5-a]pyridine-3-carboxamide [33];

5-(6-fluoro-2-(((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-isopropylpyrazolo[1,5-a]pyridine-3-carboxamide [34];

5-(6-fluoro-2-(((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-isopropylpyrazolo[1,5-a]pyridine-3-carboxamide [35];

5-(6-fluoro-2-(((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-isopropylpyrazolo[1,5-a]pyridine-3-carboxamide [36];

(R)-5-(2-((3,3-difluoro-1-methylpiperidin-4-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-isopropylpyrazolo[1,5-a]pyridine-3-carboxamide [37];

(R)-5-(2-((3,3-difluoro-1-(methyl-d3)piperidin-4-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-isopropylpyrazolo[1,5-a]pyridine-3-carboxamide [38];

(R)-5-(2-((3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-isopropylpyrazolo[1,5-a]pyridine-3-carboxamide [39];

5-(2-((2-oxaspiro[3.5]nonan-7-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-isopropylpyrazolo[1,5-a]pyridine-3-carboxamide [40];

6-(2-((2-cyano-2-methylpropyl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [41];

6-(2-(((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [42];

(R)-6-(2-((3,3-difluoro-1-methylpiperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [43];

(R)-6-(2-((3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [44];

6-(2-((2-cyano-2-methylpropyl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [45];

6-(2-((4,4-difluorocyclohexyl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [46];

(R)-6-(2-((4,4-difluoro-1-methylpyrrolidin-3-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [47];

(R)-6-(2-((4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [48];

6-(6-fluoro-4-methoxy-2-((1-(oxetan-3-yl)piperidin-4-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [49];

6-(6-fluoro-2-(((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [50];

6-(6-fluoro-2-(((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [51];

6-(6-fluoro-2-(((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [52];

6-(6-fluoro-2-(((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [53];

(R)-6-(2-((3,3-difluoro-1-methylpiperidin-4-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [54];

(R)-6-(2-((3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [55];

(R)-6-(2-((3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [56];

(1r,4r)-4-((5-(3-(difluoromethyl)-8-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [57];

(R)-1-(4-((5-(3-(difluoromethyl)-8-fluoroimidazo[1,2-a]pyridin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [58];

3-((5-(3-(difluoromethyl)-8-fluoroimidazo[1,2-a]pyridin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [59];

N-(4,4-difluorocyclohexyl)-5-(3-(difluoromethyl)-8-fluoroimidazo[1,2-a]pyridin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [60];

(1s,4s)-4-((5-(3-(difluoromethyl)-8-fluoroimidazo[1,2-a]pyridin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [61];

(1r,4r)-4-((5-(3-(difluoromethyl)-8-fluoroimidazo[1,2-a]pyridin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [62];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(3-(difluoromethyl)-8-fluoroimidazo[1,2-a]pyridin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [63];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(3-(difluoromethyl)-8-fluoroimidazo[1,2-a]pyridin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [64];

5-(3-(difluoromethyl)-8-fluoroimidazo[1,2-a]pyridin-6-yl)-6-fluoro-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [65];

5-(3-(difluoromethyl)-8-fluoroimidazo[1,2-a]pyridin-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [66];

5-(3-(difluoromethyl)-8-fluoroimidazo[1,2-a]pyridin-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [67];

5-(3-(difluoromethyl)-8-fluoroimidazo[1,2-a]pyridin-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [68];

5-(3-(difluoromethyl)-8-fluoroimidazo[1,2-a]pyridin-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [69];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(3-(difluoromethyl)-8-fluoroimidazo[1,2-a]pyridin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [70];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(3-(difluoromethyl)-8-fluoroimidazo[1,2-a]pyridin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [71];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(3-(difluoromethyl)-8-fluoroimidazo[1,2-a]pyridin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [72];

5-(3-(difluoromethyl)-8-fluoroimidazo[1,2-a]pyridin-6-yl)-6-fluoro-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [73];

6-(2-((4,4-difluorocyclohexyl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-8-fluoro-N-methylimidazo[1,2-a]pyridine-3-carboxamide [74];

8-fluoro-6-(2-(((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [75];

(R)-6-(2-((3,3-difluoro-1-methylpiperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-8-fluoro-N-methylimidazo[1,2-a]pyridine-3-carboxamide [76];

(R)-6-(2-((3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-8-fluoro-N-methylimidazo[1,2-a]pyridine-3-carboxamide [77];

6-(2-((2-cyano-2-methylpropyl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-8-fluoro-N-methylimidazo[1,2-a]pyridine-3-carboxamide [78];

6-(2-((4,4-difluorocyclohexyl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-8-fluoro-N-methylimidazo[1,2-a]pyridine-3-carboxamide [79];

(R)-6-(2-((4,4-difluoro-1-methylpyrrolidin-3-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-8-fluoro-N-methylimidazo[1,2-a]pyridine-3-carboxamide [80];

(R)-6-(2-((4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-8-fluoro-N-methylimidazo[1,2-a]pyridine-3-carboxamide [81];

8-fluoro-6-(6-fluoro-4-methoxy-2-((1-(oxetan-3-yl)piperidin-4-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [82];

8-fluoro-6-(6-fluoro-2-(((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [83];

8-fluoro-6-(6-fluoro-2-(((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [84];

8-fluoro-6-(6-fluoro-2-(((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [85];

8-fluoro-6-(6-fluoro-2-(((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyridine-3-carboxamide [86];

(R)-6-(2-((3,3-difluoro-1-methylpiperidin-4-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-8-fluoro-N-methylimidazo[1,2-a]pyridine-3-carboxamide [87];

(R)-6-(2-((3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-8-fluoro-N-methylimidazo[1,2-a]pyridine-3-carboxamide [88];

(R)-6-(2-((3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-8-fluoro-N-methylimidazo[1,2-a]pyridine-3-carboxamide [89];

6-(2-((2-oxaspiro[3.5]nonan-7-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-8-fluoro-N-methylimidazo[1,2-a]pyridine-3-carboxamide [90];

3-((5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [91];

(1s,4s)-4-((5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [92];

(1r,4r)-4-((5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [93];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [94];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [95];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [96];

5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [97];

N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [98];

N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [99]; and

1-((3R,4S)-3-fluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [100]; or a pharmaceutically acceptable salt thereof.

18 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of

1-((3R,4S)-3-fluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [101];

1-((3R,4S)-3-fluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [102];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [103];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [104];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [105];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [106];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [107];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [108];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [109];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [110];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [111];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [112];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [113];

5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [114];

3-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [115];

(1s,4s)-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [116];

(1r,4r)-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [117];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [118];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [119];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [120];

6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [121];

6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [122];

6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [123];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [124];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [125];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [126];

6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [127];

6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [128];

6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [129];

6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [130];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [131];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [132];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [133];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [134];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [135];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [136];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [137];

6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [138];

3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [139];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [140];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [141];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [142];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [143];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [144];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [145];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [146];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [147];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3R,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [148];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3S,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [149];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [150];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [151];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [152];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [153];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [154];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [155];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [156];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [157];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [158];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [159];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [160];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [161];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [162];

(R)—N-(3,3-difluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [163];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [164];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [165];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [166];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [167];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [168];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [169];

3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [170];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [171];

(1r,4r)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [172];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [173];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [174];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [175];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [176];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [177];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [178];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [179];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [180];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [181];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [182];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [183];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [184];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [185];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [186];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [187];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [188];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [189];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [190];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [191];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [192];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [193];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [194];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [195];

(R)—N-(3,3-difluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [196];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [197];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [198];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [199]; and

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [200]; or a pharmaceutically acceptable salt thereof.

19 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [201];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [202];

5-(1-(2,2-difluoroethyl)-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [203];

3-((5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [204];

(1s,4s)-4-((5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [205];

(1r,4r)-4-((5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [206];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [207];

(R)-1-(3,3-difluoro-4-((5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [208];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [209];

5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [210];

5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [211];

5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [212];

1-((3R,4S)-3-fluoro-4-((5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [213];

1-((3R,4S)-3-fluoro-4-((5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [214];

1-((3R,4S)-3-fluoro-4-((5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [215];

5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [216];

5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [217];

5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [218];

5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [219];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [220];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [221];

(R)-1-(3,3-difluoro-4-((5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [222];

(R)-1-(3,3-difluoro-4-((5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [223];

(R)-1-(3,3-difluoro-4-((5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [224];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [225];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [226];

5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [227];

3-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [228];

(1s,4s)-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [229];

(1r,4r)-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [230];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [231];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [232];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [233];

6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [234];

6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [235];

6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [236];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [237];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [238];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [239];

6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [240];

6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [241];

6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [242];

6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [243];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [244];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [245];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [246];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [247];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [248];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [249];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [250];

6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [251];

3-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [252];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [253];

(1r,4r)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [254];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [255];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [256];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [257];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [258];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [259];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [260];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [261];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-N-((3R,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [262];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-N-((3S,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [263];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [264];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [265];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [266];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [267];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [268];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [269];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [270];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [271];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [272];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [273];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [274];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [275];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [276];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [277];

(R)—N-(3,3-difluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [278];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [279];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [280];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [281];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [282];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [283];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [284];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [285];

3-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [286];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [287];

(1r,4r)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [288];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [289];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [290];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [291];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [292];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [293];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [294];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [295];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [296];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [297];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [298];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [299]; and

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [300]; or a pharmaceutically acceptable salt thereof.

20 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [301];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [302];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [303];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [304];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [305];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [306];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [307];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [308];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [309];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [310];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [311];

(R)—N-(3,3-difluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [312];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [313];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [314];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [315];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [316];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [317];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [318];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [319];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [320];

(1r,4r)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [321];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [322];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [323];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [324];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )—N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [325];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [326];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [327];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [328];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [329];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [330];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [331];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [332];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [333];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [334];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [335];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [336];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [337];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [338];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [339];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [340];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [341];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )—N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [342];

(R)-1-(4-((5-(benzo[d]thiazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [343];

3-((5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [344];

(1s,4s)-4-((5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [345];

(1r,4r)-4-((5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [346];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [347];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [348];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [349];

5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [350];

N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [351];

N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [352];

1-((3R,4S)-3-fluoro-4-((5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [353];

1-((3R,4S)-3-fluoro-4-((5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [354];

1-((3R,4S)-3-fluoro-4-((5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [355];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [356];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [357];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [358];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [359];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [360];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [361];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [362];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [363];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [364];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [365];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [366];

5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [367];

3-((6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [368];

(1s,4s)-4-((6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [369];

(1r,4r)-4-((6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [370];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [371];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [372];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [373];

6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [374];

6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [375];

6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [376];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [377];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [378];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [379];

6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [380];

6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [381];

6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [382];

6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [383];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [384];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [385];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [386];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [387];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [388];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [389];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [390];

6-fluoro-5-(1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [391];

3-((5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [392];

(1s,4s)-4-((5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [393];

(1r,4r)-4-((5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [394];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [395];

(R)-1-(3,3-difluoro-4-((5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [396];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [397];

5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [398];

5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [399]; and

5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [400]; or a pharmaceutically acceptable salt thereof.

21 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of

1-((3R,4S)-3-fluoro-4-((5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [401];

1-((3R,4S)-3-fluoro-4-((5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [402];

1-((3R,4S)-3-fluoro-4-((5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [403];

5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [404];

5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [405];

5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [406];

5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [407];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [408];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [409];

(R)-1-(3,3-difluoro-4-((5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [410];

(R)-1-(3,3-difluoro-4-((5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [411];

(R)-1-(3,3-difluoro-4-((5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [412];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [413];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [414];

5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [415];

3-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [416];

(1s,4s)-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [417];

(1r,4r)-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [418];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [419];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [420];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [421];

6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [422];

6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [423];

6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [424];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [425];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [426];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [427];

6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [428];

6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [429];

6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [430];

6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [431];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [432];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [433];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [434];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [435];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [436];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [437];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [438];

6-fluoro-5-(4-fluoro-1-(2-fluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [439];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [440];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3R,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [441];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3S,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [442];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [443];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [444];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [445];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [446];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [447];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [448];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [449];

(R)—N-(3,3-difluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [450];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [451];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [452];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [453];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [454];

3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [455];

(1S,4S)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [456];

(1R,4R)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [457];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [458];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [459];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [460];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [461];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [462];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [463];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [464];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [465];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [466];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [467];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [468];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [469];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [470];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [471];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [472];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [473];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [474];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [475];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [476];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [477];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [478];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [479];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [480];

(R)—N-(3,3-difluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [481];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [482];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [483];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [484];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [485];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [486];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [487];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [488];

(1S,4S)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [489];

(1R,4R)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [490];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [491];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [492];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [493];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )—N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [494];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [495];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [496];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [497];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [498];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [499]; and

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [500]; or a pharmaceutically acceptable salt thereof.

22 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [501];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [502];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [503];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [504];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [505];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [506];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [507];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [508];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [509];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [510];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )—N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [511];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [512];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3R,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [513];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3S,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [514];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [515];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [516];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [517];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [518];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [519];

(R)—N-(3,3-difluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [520];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [521];

3-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [522];

(1S,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [523];

(1R,4R)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [524];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [525];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [526];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [527];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [528];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [529];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [530];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [531];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [532];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [533];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [534];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [535];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [536];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [537];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [538];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [539];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [540];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [541];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [542];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [543];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [544];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [545];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [546];

(R)—N-(3,3-difluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [547];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [548];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [549];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [550];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [551];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [552];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [553];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [554];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [555];

(1S,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [556];

(1R,4R)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [557];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [558];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [559];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [560];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )—N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [561];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [562];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [563];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [564];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [565];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [567];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [568];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [569];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [570];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [571];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [572];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [573];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [574];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [576];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [577];

5-(1-(2,2-difluoroethyl)-4-fluoro-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-(methoxy-d 3 )—N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [578];

3-((4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [579];

(1S,4S)-4-((4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [580];

(1R,4R)-4-((4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [581];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [582];

(R)-1-(3,3-difluoro-4-((4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [583];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [584];

4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [585];

N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [586];

N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [587];

1-((3R,4S)-3-fluoro-4-((4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [588];

1-((3R,4S)-3-fluoro-4-((4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [589];

1-((3R,4S)-3-fluoro-4-((4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [590];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [591];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [592];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [593];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [594];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [595];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [596];

(R)-1-(3,3-difluoro-4-((4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [597];

(R)-1-(3,3-difluoro-4-((4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [598];

(R)-1-(3,3-difluoro-4-((4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [599]; and

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [600]; or a pharmaceutically acceptable salt thereof.

23 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [601];

4-methoxy-5-(2-methyl-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazol-6-yl)-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [602];

(R)-1-(3,3-difluoro-4-((4-methoxy-5-(2-methylbenzo[d]oxazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [603];

(R)-1-(3,3-difluoro-4-((4-methoxy-5-(2-methylbenzo[d]thiazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [604];

(1S,3S)-3-((5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclobutan-1-ol [605];

(1R,3R)-3-((5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclobutan-1-ol [606];

N-((1R,3R)-3-((5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclobutyl)-2-hydroxyacetamide [607];

(1R,3S)-1-ethyl-3-((4-methoxy-5-(1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)cyclobutan-1-ol [608];

(1R,3S)-1-ethyl-3-((5-(1-ethyl-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)cyclobutan-1-ol [609];

3-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [610];

(1S,3R)-1-ethyl-3-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)cyclobutan-1-ol [611];

N-((1S,4S)-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)cyclohexyl)acetamide [612];

1-((3S,4R)-3-fluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)propan-1-one [613];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [614];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [615];

2-((3R,4S)-3-fluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-ol [616];

N-((3S,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [617];

N-((3R,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [618];

N-((3S,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [619];

N-((3R,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [620];

2-((3R,4S)-3-fluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-N,N-dimethylacetamide [621];

1-(azetidin-1-yl)-2-((3R,4S)-3-fluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [622];

1-((3R,4S)-3-fluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [623];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [624];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [625];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [626];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [627];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [628];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [629];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [630];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [631];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [632];

(R)-2-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-ol [633];

(R)—N-(3,3-difluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [634];

(R)-1-(azetidin-1-yl)-2-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [635];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-(dimethylamino)ethan-1-one [636];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [637];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [638];

(1S,4S)-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)-1-methylcyclohexan-1-ol [639];

(1R,4R)-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)-1-methylcyclohexan-1-ol [640];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [641];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)pyrrolidin-1-yl)ethan-1-one [642];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [643];

5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [644];

N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [645];

N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [646];

1-((3R,4S)-3-fluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)ethan-1-one [647];

1-((3R,4S)-3-fluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [648];

1-((3R,4S)-3-fluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)-2-hydroxyethan-1-one [649];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [650];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [651];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [652];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [653];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [654];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [655];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)ethan-1-one [656];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [657];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)-2-hydroxyethan-1-one [658];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [659];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [660];

5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [661];

(1S,4S)-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [662];

(1R,4R)-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [663];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [664];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [665];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [666];

5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )—N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [667];

N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [668];

N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [669];

1-((3R,4S)-3-fluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [670];

1-((3R,4S)-3-fluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [671];

1-((3R,4S)-3-fluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [672];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [673];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [674];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [675];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [676];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [677];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [678];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [679];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [680];

(R)-1-(3,3-difluoro-4-((5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [681];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d)pyrrolo[2,1-f][1,2,4]triazin-2-amine [682];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [683];

5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )—N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [684];

3-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [685];

(1r,4r)-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [686];

1-((3S,4R)-3-fluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [687];

6-fluoro-N-((3R,4S)-4-fluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [688];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [689];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [690];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [691];

6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [692];

6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [693];

6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [694];

6-fluoro-N-((3S,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [695];

6-fluoro-N-((3R,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [696];

6-fluoro-N-((3S,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [697];

6-fluoro-N-((3R,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [698];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [699]; and

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [700]; or

a pharmaceutically acceptable salt thereof.

24 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [701];

6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [702];

6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [703];

6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [704];

6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [705];

6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [706];

6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [707];

6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [708];

6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [709];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [710];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [711];

(R)—N-(3,3-difluoro-1-(2-methoxyethyl)piperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [712];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [713];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [714];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [715];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [716];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [717];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [718];

6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [719];

(1S,4S)-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)-1-methylcyclohexan-1-ol [720];

(1R,4R)-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)-1-methylcyclohexan-1-ol [721];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [722];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)pyrrolidin-1-yl)ethan-1-one [723];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [724];

6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [725];

6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [726];

6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [727];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)ethan-1-one [728];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [729];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)-2-hydroxyethan-1-one [730];

6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [731];

6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [732];

6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [733];

6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [734];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [735];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [736];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)ethan-1-one [737];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [738];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)-2-hydroxyethan-1-one [739];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [740];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [741];

6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [742];

(1S,4S)-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [743];

(1R,4R)-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [744];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [745];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [746];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [747];

6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d)-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [748];

6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [749];

6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [750];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [751];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [752];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [753];

6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [754];

6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [755];

6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [756];

6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [757];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [758];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [759];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [760];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [761];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [762];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [763];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [764];

6-fluoro-5-(1-(2-fluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )—N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [765];

2-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-morpholinoethan-1-one [766];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [767];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [768];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [769];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [770];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [771];

2-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-N,N-dimethylacetamide [772];

1-(azetidin-1-yl)-2-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [773];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [774];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-(pyrrolidin-1-yl)ethan-1-one [775];

(3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoro-N-methylpiperidine-1-carboxamide [776];

(3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoro-N,N-dimethylpiperidine-1-carboxamide [777];

((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)(pyrrolidin-1-yl)methanone [778];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [779];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [780];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [781];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [782];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [783];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [784];

(S)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [785];

(R)—N-(3,3-difluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [786];

(R)-1-(azetidin-1-yl)-2-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [787];

(S)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [788];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [789];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-(dimethylamino)ethan-1-one [790];

(R)-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)(pyrrolidin-1-yl)methanone [791];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [792];

(S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylpiperidin-2-one [793];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [794];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [795];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [796];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [797];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [798];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [799]; and

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [800]; or a pharmaceutically acceptable salt thereof.

25 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [801];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [802];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [803];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [804];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [805];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [806];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [807];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [808];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [809];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [810];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [811];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [812];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [813];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [814];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [815];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [816];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [817];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [818];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [819];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [820];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-(methoxy-d)-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [821];

3-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [822];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-4-fluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [823];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [824];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [825];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [826];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [827];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [828];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [829];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [830];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [831];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [832];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [833];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [834];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [835];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [836];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [837];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [838];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [839];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [840];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [841];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [842];

(R)—N-(3,3-difluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [843];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [844];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [845];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [846];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [847];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [848];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [849];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [850];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [851];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [852];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [853];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [854];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [855];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [856];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [857];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [858];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [859];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [860];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [861];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [862];

(1s,4s)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [863];

(1r,4r)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [864];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [865];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [866];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [867];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-(methoxy-d 3 )—N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [868];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [869];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [870];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [871];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [872];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [873];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [874];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [875];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [876];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [877];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [878];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [879];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [880];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [881];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [882];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [883];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-amine [884];

5-(1-(2,2-difluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-(methoxy-d 3 )—N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine 885];

N-((1s,4s)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)cyclohexyl)acetamide [886];

2-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-ol [887];

1-((3R,4S)-4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [888];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [889];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [890];

5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [891];

(R)-2-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-ol [892];

(R)-1-(4-((5-(1-(2,2-difluoroethyl)-4-fluoro-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [893];

3-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [894];

N-((1s,4s)-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)cyclohexyl)acetamide [895];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [896];

(R)-1-(3,3-difluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [897];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [898];

2-((3R,4S)-3-fluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-ol [899]; and

N-((3S,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [900]; or a pharmaceutically acceptable salt thereof.

26 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of

N-((3R,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [901];

N-((3S,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [902];

N-((3R,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [903];

2-((3R,4S)-3-fluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-N,N-dimethylacetamide [904];

1-((3R,4S)-3-fluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [905];

1-((3R,4S)-3-fluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-(pyrrolidin-1-yl)ethan-1-one [906];

((3R,4S)-3-fluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)(pyrrolidin-1-yl)methanone [907];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [908];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [909];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [910];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [911];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [912];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [913];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [914];

(R)-2-(3,3-difluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-ol [915];

(R)—N-(3,3-difluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [916];

(R)-1-(3,3-difluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [917];

(R)-1-(3,3-difluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-(dimethylamino)ethan-1-one [918];

(R)-1-(3,3-difluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-(pyrrolidin-1-yl)ethan-1-one [919];

(R)-(3,3-difluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)(pyrrolidin-1-yl)methanone [920];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [921];

(1s,4s)-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)-1-methylcyclohexan-1-ol [922];

(1r,4r)-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)-1-methylcyclohexan-1-ol [923];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [924];

(R)-1-(3,3-difluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)pyrrolidin-1-yl)ethan-1-one [925];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [926];

4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [927];

N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [928];

N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [929];

1-((3R,4S)-3-fluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)ethan-1-one [930];

1-((3R,4S)-3-fluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [931];

1-((3R,4S)-3-fluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)-2-hydroxyethan-1-one [932];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [933];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [934];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [935];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [936];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [937];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [938];

(R)-1-(3,3-difluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)ethan-1-one [939];

(R)-1-(3,3-difluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [940];

(R)-1-(3,3-difluoro-4-((4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl-7-d)amino)piperidin-1-yl)-2-hydroxyethan-1-one [941];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [942];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [943];

4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-d-2-amine [944];

(1s,4s)-4-((4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [945];

(1r,4r)-4-((4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [946];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [947];

(R)-1-(3,3-difluoro-4-((4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [948];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [949];

4-(methoxy-d 3 )—N-(1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [950];

N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [951];

N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [952];

1-((3R,4S)-3-fluoro-4-((4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [953];

1-((3R,4S)-3-fluoro-4-((4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [954];

1-((3R,4S)-3-fluoro-4-((4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [955];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d)-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [956];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [957];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d)-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [958];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [959];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [960];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [961];

(R)-1-(3,3-difluoro-4-((4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [962];

(R)-1-(3,3-difluoro-4-((4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [963];

(R)-1-(3,3-difluoro-4-((4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [964];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [965];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [966];

4-(methoxy-d 3 )—N-(2-oxaspiro[3.5]nonan-7-yl)-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [967];

3-((6-fluoro-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [968];

1-((3S,4R)-3-fluoro-4-((6-fluoro-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [969];

6-fluoro-N-((3R,4S)-4-fluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [970];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-6-fluoro-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [971];

(R)-1-(3,3-difluoro-4-((6-fluoro-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [972];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-6-fluoro-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [973];

6-fluoro-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [974];

6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [975];

6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [976];

6-fluoro-N-((3S,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [977];

6-fluoro-N-((3R,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [978];

6-fluoro-N-((3S,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [979];

6-fluoro-N-((3R,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [980];

1-((3R,4S)-3-fluoro-4-((6-fluoro-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [981];

1-((3R,4S)-3-fluoro-4-((6-fluoro-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [982];

1-((3R,4S)-3-fluoro-4-((6-fluoro-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [983];

6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [984];

6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [985];

6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [986];

6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [987];

6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [988];

6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [989];

6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [990];

6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [991];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-6-fluoro-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [992];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-6-fluoro-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [993];

(R)—N-(3,3-difluoro-1-(2-methoxyethyl)piperidin-4-yl)-6-fluoro-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [994];

(R)-1-(3,3-difluoro-4-((6-fluoro-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [995];

(R)-1-(3,3-difluoro-4-((6-fluoro-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [996];

(R)-1-(3,3-difluoro-4-((6-fluoro-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [997];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-6-fluoro-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [998];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-6-fluoro-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [999]; and

(R)—N-(3,3-difluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-6-fluoro-4-methoxy-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1000]; or

a pharmaceutically acceptable salt thereof.

27 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

6-fluoro-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1001];

(1s,4s)-4-((6-fluoro-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1002];

(1r,4r)-4-((6-fluoro-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1003];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-6-fluoro-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1004];

(R)-1-(3,3-difluoro-4-((6-fluoro-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [1005];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-6-fluoro-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1006];

6-fluoro-4-(methoxy-d 3 )—N-(1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1007];

6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1008];

6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1009];

1-((3R,4S)-3-fluoro-4-((6-fluoro-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1010];

1-((3R,4S)-3-fluoro-4-((6-fluoro-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1011];

1-((3R,4S)-3-fluoro-4-((6-fluoro-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1012];

6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1013];

6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1014];

6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1015];

6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1016];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-6-fluoro-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1017];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-6-fluoro-4-(methoxy-d)-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1018];

(R)-1-(3,3-difluoro-4-((6-fluoro-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [109];

(R)-1-(3,3-difluoro-4-((6-fluoro-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1020];

(R)-1-(3,3-difluoro-4-((6-fluoro-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1021];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-6-fluoro-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1022];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-6-fluoro-4-(methoxy-d 3 )-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1023];

6-fluoro-4-(methoxy-d 3 )—N-(2-oxaspiro[3.5]nonan-7-yl)-5-(1-(2,2,2-trifluoroethyl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1024];

(1r,4r)-4-((4-methoxy-5-(1-propyl-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1025];

(R)-1-(3,3-difluoro-4-((4-methoxy-5-(1-propyl-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1026];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-propyl-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1027];

3-((5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1028];

(1s,4s)-4-((5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1029];

(1r,4r)-4-((5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1030];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1031];

(R)-1-(3,3-difluoro-4-((5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [1032];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1033];

5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1034];

N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1035];

N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1036];

1-((3R,4S)-3-fluoro-4-((5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1037];

1-((3R,4S)-3-fluoro-4-((5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1038];

1-((3R,4S)-3-fluoro-4-((5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1039];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1040];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1041];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1042];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1043];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1044];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1045];

(R)-1-(3,3-difluoro-4-((5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1046];

(R)-1-(3,3-difluoro-4-((5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1047];

(R)-1-(3,3-difluoro-4-((5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1048];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1049];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1050];

5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1051];

3-((6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1052];

(1s,4s)-4-((6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1053];

(1r,4r)-4-((6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1054];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1055];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [1056];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1057];

6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1058];

6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1059];

6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1060];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1061];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1062];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1063];

6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1064];

6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1065];

6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1066];

6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1067];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1068];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1069];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1070];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1071];

(R)-1-(3,3-difluoro-4-((6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1072];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1073];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1074];

6-fluoro-5-(1-(3-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1075];

(S)-3-((5-(1-(2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1076];

(1R,4s)-4-((5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1077];

(1S,4r)-4-((5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1078];

N—((R)-4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1079];

1-((R)-3,3-difluoro-4-((5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [1080];

N—((R)-4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1081];

(S)-5-(1-(2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1082];

N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1083];

N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1084];

1-((3R,4S)-3-fluoro-4-((5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1085];

1-((3R,4S)-3-fluoro-4-((5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1086];

1-((3R,4S)-3-fluoro-4-((5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1087];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1088];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1089];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1090];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1091];

N—((R)-3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1092];

N—((R)-3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1093];

1-((R)-3,3-difluoro-4-((5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1094];

1-((R)-3,3-difluoro-4-((5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1095];

1-((R)-3,3-difluoro-4-((5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1096];

N—((R)-3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1097];

N—((R)-3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1098];

(S)-5-(1-(2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1099]; and

(R)-3-((5-(1-(2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1100]; or a pharmaceutically acceptable salt thereof.

28 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of

(1S,4s)-4-((5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1101];

(1R,4r)-4-((5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1102];

N—((R)-4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1103];

1-((R)-3,3-difluoro-4-((5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [1104];

N—((R)-4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1105];

(R)-5-(1-(2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1106];

N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1107];

N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1108];

1-((3R,4S)-3-fluoro-4-((5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1109];

1-((3R,4S)-3-fluoro-4-((5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1110];

1-((3R,4S)-3-fluoro-4-((5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1111];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1112];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1113];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1114];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1115];

N—((R)-3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1116];

N—((R)-3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1117];

1-((R)-3,3-difluoro-4-((5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1118];

1-((R)-3,3-difluoro-4-((5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1119];

1-((R)-3,3-difluoro-4-((5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1120];

N—((R)-3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1121];

N—((R)-3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1122];

(R)-5-(1-(2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1123];

(S)-3-((6-fluoro-5-(1-(2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1124];

(1R,4s)-4-((6-fluoro-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1125];

(1S,4r)-4-((6-fluoro-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1126];

N—((R)-4,4-difluoro-1-methylpyrrolidin-3-yl)-6-fluoro-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1127];

1-((R)-3,3-difluoro-4-((6-fluoro-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [1128];

N—((R)-4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-6-fluoro-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1129];

(S)-6-fluoro-5-(1-(2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1130];

6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1131];

6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1132];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1133];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1134];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1135];

6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1136];

6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1137];

6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1138];

6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1139];

N—((R)-3,3-difluoro-1-methylpiperidin-4-yl)-6-fluoro-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1140];

N—((R)-3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-6-fluoro-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1141];

1-((R)-3,3-difluoro-4-((6-fluoro-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1142];

1-((R)-3,3-difluoro-4-((6-fluoro-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1143];

1-((R)-3,3-difluoro-4-((6-fluoro-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1144];

N—((R)-3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-6-fluoro-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1145];

N—((R)-3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-6-fluoro-5-(1-((S)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1146];

(S)-6-fluoro-5-(1-(2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1147];

(R)-3-((6-fluoro-5-(1-(2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1148];

(1S,4s)-4-((6-fluoro-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1149];

(1R,4r)-4-((6-fluoro-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1150];

N—((R)-4,4-difluoro-1-methylpyrrolidin-3-yl)-6-fluoro-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1151];

1-((R)-3,3-difluoro-4-((6-fluoro-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [1152];

N—((R)-4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-6-fluoro-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1153];

(R)-6-fluoro-5-(1-(2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1154];

6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1155];

6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1156];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1157];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1158];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1159];

6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1160];

6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1161];

6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1162];

6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1163];

N—((R)-3,3-difluoro-1-methylpiperidin-4-yl)-6-fluoro-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1164];

N—((R)-3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-6-fluoro-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1165];

1-((R)-3,3-difluoro-4-((6-fluoro-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1166];

1-((R)-3,3-difluoro-4-((6-fluoro-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1167];

1-((R)-3,3-difluoro-4-((6-fluoro-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1168];

N—((R)-3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-6-fluoro-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1169];

N—((R)-3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-6-fluoro-5-(1-((R)-2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1170];

(R)-6-fluoro-5-(1-(2-fluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1171];

(S)-3-((5-(1-(1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1172];

N-((1R,4s)-4-((5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)cyclohexyl)acetamide [1173];

(1R,4s)-4-((5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1174];

(1S,4r)-4-((5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1175];

N—((R)-4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1176];

1-((R)-3,3-difluoro-4-((5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [1177];

N—((R)-4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1178];

(S)-5-(1-(1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1179];

N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1180];

N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1181];

1-((3R,4S)-3-fluoro-4-((5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1182];

1-((3R,4S)-3-fluoro-4-((5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1183];

1-((3R,4S)-3-fluoro-4-((5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1184];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1185];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1186];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1187];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1188];

N—((R)-3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1189];

N—((R)-3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1190];

1-((R)-3,3-difluoro-4-((5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1191];

1-((R)-3,3-difluoro-4-((5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1192];

1-((R)-3,3-difluoro-4-((5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1193];

N—((R)-3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1194];

N—((R)-3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1195];

(S)-5-(1-(1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1196];

(R)-3-((5-(1-(1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1197];

(1S,4s)-4-((5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1198];

(1R,4r)-4-((5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1199]; and

N—((R)-4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1200]; or a pharmaceutically acceptable salt thereof.

29 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of

1-((R)-3,3-difluoro-4-((5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [1201];

N—((R)-4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1202];

(R)-5-(1-(1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1203];

N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1204];

N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1205];

1-((3R,4S)-3-fluoro-4-((5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1206];

1-((3R,4S)-3-fluoro-4-((5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1207];

1-((3R,4S)-3-fluoro-4-((5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1208];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1209];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1210];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1211];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1212];

N—((R)-3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1213];

N—((R)-3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1214];

1-((R)-3,3-difluoro-4-((5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1215];

1-((R)-3,3-difluoro-4-((5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1216];

1-((R)-3,3-difluoro-4-((5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [ 1217 ];

N—((R)-3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1218];

N—((R)-3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1219];

(R)-5-(1-(1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1220];

(S)-3-((6-fluoro-5-(1-(1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1221];

(1R,4s)-4-((6-fluoro-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1222];

(1S,4r)-4-((6-fluoro-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1223];

N—((R)-4,4-difluoro-1-methylpyrrolidin-3-yl)-6-fluoro-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1224];

1-((R)-3,3-difluoro-4-((6-fluoro-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [1225];

N—((R)-4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-6-fluoro-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1226];

(S)-6-fluoro-5-(1-(1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1227];

6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1228];

6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1229];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1230];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1231];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1232];

6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1233];

6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1234];

6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1235];

6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1236];

N—((R)-3,3-difluoro-1-methylpiperidin-4-yl)-6-fluoro-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1237];

N—((R)-3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-6-fluoro-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1238];

1-((R)-3,3-difluoro-4-((6-fluoro-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1239];

1-((R)-3,3-difluoro-4-((6-fluoro-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1240];

1-((R)-3,3-difluoro-4-((6-fluoro-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1241];

N—((R)-3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-6-fluoro-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1242];

N—((R)-3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-6-fluoro-5-(1-((S)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1243];

(S)-6-fluoro-5-(1-(1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1244];

(R)-3-((6-fluoro-5-(1-(1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1245];

(1S,4s)-4-((6-fluoro-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1246];

(1R,4r)-4-((6-fluoro-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1247];

N—((R)-4,4-difluoro-1-methylpyrrolidin-3-yl)-6-fluoro-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1248];

1-((R)-3,3-difluoro-4-((6-fluoro-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [1249];

N—((R)-4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-6-fluoro-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1250];

(R)-6-fluoro-5-(1-(1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1251];

6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1252];

6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1253];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1254];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1255];

1-((3R,4S)-3-fluoro-4-((6-fluoro-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1256];

6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1257];

6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1258];

6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1259];

6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1260];

N—((R)-3,3-difluoro-1-methylpiperidin-4-yl)-6-fluoro-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1261];

N—((R)-3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-6-fluoro-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1262];

1-((R)-3,3-difluoro-4-((6-fluoro-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1263];

1-((R)-3,3-difluoro-4-((6-fluoro-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1264];

1-((R)-3,3-difluoro-4-((6-fluoro-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1265];

N—((R)-3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-6-fluoro-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1266];

N—((R)-3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-6-fluoro-5-(1-((R)-1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1267];

(R)-6-fluoro-5-(1-(1-fluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1268];

(1S,4r)-4-((5-(1-((S)-1-hydroxypropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1269];

(S)-2-(6-(2-(((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-1H-benzo[d][1,2,3]triazol-1-yl)propan-1-ol [1270];

1-((R)-3,3-difluoro-4-((5-(1-((S)-1-hydroxypropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1271];

(1R,4r)-4-((5-(1-((R)-1-hydroxypropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1272];

(R)-2-(6-(2-(((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-1H-benzo[d][1,2,3]triazol-1-yl)propan-1-ol [1273];

1-((R)-3,3-difluoro-4-((5-(1-((R)-1-hydroxypropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1274];

3-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1275];

(1s,4s)-4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1276];

(1r,4r)-4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1277];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1278];

(R)-1-(4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [1279];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1280];

5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1281];

5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1282];

5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1283];

1-((3R,4S)-4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [1284];

1-((3R,4S)-4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1285];

1-((3R,4S)-4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [1286];

5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1287];

5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1288];

5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1289];

5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1290];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1291];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1292];

(R)-1-(4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [1293];

(R)-1-(4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1294];

(R)-1-(4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [1295];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1296];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1297];

5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1298];

3-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1299]; and

(1s,4s)-4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol[1300]; or a pharmaceutically acceptable salt thereof.

30 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of

(1r,4r)-4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1301];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1302];

(R)-1-(4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [1303];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1304];

5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1305];

5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1306];

5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1307];

1-((3R,4S)-4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [1308];

1-((3R,4S)-4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1309];

1-((3R,4S)-4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [1310];

5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1311];

5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1312];

5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1313];

5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1314];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1315];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1316];

(R)-1-(4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [1317];

(R)-1-(4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1318];

(R)-1-(4-((5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [1319];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1320];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1321];

5-(1-(3,3-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1322];

3-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1323];

(1s,4s)-4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1324];

(1r,4r)-4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1325];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1326];

(R)-1-(4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [1327];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1328];

5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1329];

5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1330];

5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1331];

1-((3R,4S)-4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [1332];

1-((3R,4S)-4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1333];

1-((3R,4S)-4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [1334];

5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1335];

5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1336];

5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1337];

5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1338];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1339];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1340];

(R)-1-(4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [1341];

(R)-1-(4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1342];

(R)-1-(4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [1343];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1344];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1345];

5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1346];

3-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1347];

(1s,4s)-4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1348];

(1r,4r)-4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1349];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1350];

(R)-1-(4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [1351];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1352];

5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1353];

5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1354];

5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1355];

1-((3R,4S)-4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [1356];

1-((3R,4S)-4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1357];

1-((3R,4S)-4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [1358];

5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1359];

5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1360];

5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1361];

5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1362];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1363];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1364];

(R)-1-(4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [1365];

(R)-1-(4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1366];

(R)-1-(4-((5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [1367];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1368];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1369];

5-(1-(2,2-difluoropropyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1370];

(S)-3-((5-(1-(1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1371];

(1R,4s)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1372];

(1S,4r)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1373];

N—((R)-4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1374];

1-((R)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [1375];

N—((R)-4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1376];

(S)-5-(1-(1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1377];

5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1378];

5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1379];

1-((3R,4S)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [1380];

1-((3R,4S)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1381];

1-((3R,4S)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [1382];

5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1383];

5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1384];

5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1385];

5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1386];

N—((R)-3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1387];

N—((R)-3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1388];

1-((R)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [1389];

1-((R)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1390];

1-((R)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [1391];

N—((R)-3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1392];

N—((R)-3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1393];

(S)-5-(1-(1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1394];

(S)-3-((5-(1-(1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1395];

(1R,4s)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1396];

(1S,4r)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1397];

N—((R)-4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1398];

1-((R)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [1399]; and

N—((R)-4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1400]; or a pharmaceutically acceptable salt thereof.

31 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of

(S)-5-(1-(1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1401];

5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1402];

5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1403];

1-((3R,4S)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [1404];

1-((3R,4S)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1405];

1-((3R,4S)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [1406];

5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1407];

5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1408];

5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1409];

5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1410];

N—((R)-3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1411];

N—((R)-3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1412];

1-((R)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [ 1413 ];

1-((R)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1414];

1-((R)-4-((5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [1415];

N—((R)-3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1416];

N—((R)-3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((S)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1417];

(S)-5-(1-(1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1418];

(R)-3-((5-(1-(1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1419];

(1S,4s)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1420];

(1R,4r)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1421];

N—((R)-4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1422];

1-((R)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [1423];

N—((R)-4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1424];

(R)-5-(1-(1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1425];

5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1426];

5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1427];

1-((3R,4S)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [1428];

1-((3R,4S)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1429];

1-((3R,4S)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [1430];

5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1431];

5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1432];

5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1433];

5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1434];

N—((R)-3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1435];

N—((R)-3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1436];

1-((R)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [1437];

1-((R)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1438];

1-((R)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [1439];

N—((R)-3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1440];

N—((R)-3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1441];

(R)-5-(1-(1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1442];

(R)-3-((5-(1-(1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1443];

(1S,4s)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1444];

(1R,4r)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1445];

N—((R)-4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1446];

1-((R)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [1447];

N—((R)-4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1448];

(R)-5-(1-(1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1449];

5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1450];

5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1451];

1-((3R,4S)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [1452];

1-((3R,4S)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1453];

1-((3R,4S)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [1454];

5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1455];

5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1456];

5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1457];

5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1458];

N—((R)-3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1459];

N—((R)-3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1460];

1-((R)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [1461];

1-((R)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1462];

1-((R)-4-((5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [1463];

N—((R)-3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1464];

N—((R)-3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-((R)-1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1465];

(R)-5-(1-(1,1-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1466];

3-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1467];

N-((1s,4s)-4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)cyclohexyl)acetamide [1468];

(1s,4s)-4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1469];

(1r,4r)-4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1470];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1471];

(R)-1-(4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [1472];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1473];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1474];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1475];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1476];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1477];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1478];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1479];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1480];

1-((3R,4S)-4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [1481];

1-((3R,4S)-4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1482];

1-((3R,4S)-4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [1483];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1484];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1485];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1486];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1487];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1488];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1489];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1490];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1491];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1492];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1493];

(R)—N-(3,3-difluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1494];

(R)-1-(4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [1495];

(R)-1-(4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1496];

(R)-1-(4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [1497];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1498];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1499]; and

(R)—N-(3,3-difluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1500]; or a pharmaceutically acceptable salt thereof.

32 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1501];

3-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1502];

(1s,4s)-4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1503];

(1r,4r)-4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1504];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1505];

(R)-1-(4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [1506];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1507];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1508];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1509];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1510];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1511];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1512];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1513];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(2-methoxyethyl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1514];

1-((3R,4S)-4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [1515];

1-((3R,4S)-4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1516];

1-((3R,4S)-4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [1517];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1518];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1519];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1520];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1521];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1522];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1523];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1524];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1525];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1526];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1527];

(R)—N-(3,3-difluoro-1-(2-methoxyethyl)piperidin-4-yl)-5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1528];

(R)-1-(4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [1529];

(R)-1-(4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1530];

(R)-1-(4-((5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [1531];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1532];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1533];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl-3-d)piperidin-4-yl)-5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1534];

5-(1-(1,3-difluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1535];

(S)-3-((4-methoxy-5-(1-(1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1536];

(1R,4s)-4-((4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1537];

(1S,4r)-4-((4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1538];

N—((R)-4,4-difluoro-1-methylpyrrolidin-3-yl)-4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1539];

1-((R)-3,3-difluoro-4-((4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [1540];

N—((R)-4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1541];

(S)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1542];

N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1543];

N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1544];

1-((3R,4S)-3-fluoro-4-((4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1545];

1-((3R,4S)-3-fluoro-4-((4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1546];

1-((3R,4S)-3-fluoro-4-((4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1547];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1548];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1549];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1550];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1551];

N—((R)-3,3-difluoro-1-methylpiperidin-4-yl)-4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1552];

N—((R)-3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1553];

1-((R)-3,3-difluoro-4-((4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1554];

1-((R)-3,3-difluoro-4-((4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1555];

1-((R)-3,3-difluoro-4-((4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1556];

N—((R)-3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1557];

N—((R)-3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-((S)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1558];

(S)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)-5-(1-(1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1559];

(R)-3-((4-methoxy-5-(1-(1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1560];

(1S,4s)-4-((4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1561];

(1R,4r)-4-((4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1562];

N—((R)-4,4-difluoro-1-methylpyrrolidin-3-yl)-4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1563];

1-((R)-3,3-difluoro-4-((4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)pyrrolidin-1-yl)ethan-1-one [1564];

N—((R)-4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1565];

(R)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1566];

N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1567];

N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1568];

1-((3R,4S)-3-fluoro-4-((4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1569];

1-((3R,4S)-3-fluoro-4-((4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1570];

1-((3R,4S)-3-fluoro-4-((4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1571];

N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1572];

N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1573];

N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1574];

N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1575];

N—((R)-3,3-difluoro-1-methylpiperidin-4-yl)-4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1576];

N—((R)-3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1577];

1-((R)-3,3-difluoro-4-((4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1578];

1-((R)-3,3-difluoro-4-((4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one-2,2,2-d 3 [1579];

1-((R)-3,3-difluoro-4-((4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)-2-hydroxyethan-1-one [1580];

N—((R)-3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1581];

N—((R)-3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxy-5-(1-((R)-1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1582];

(R)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)-5-(1-(1,1,1-trifluoropropan-2-yl)-1H-benzo[d][1,2,3]triazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1583];

3-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1584];

(1s,4s)-4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1585];

(1r,4r)-4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1586];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1587];

(R)-1-(4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [1588];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1589];

5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1590];

5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1591];

5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1592];

1-((3R,4S)-4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [1593];

1-((3R,4S)-4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1594];

1-((3R,4S)-4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [1595];

5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1596];

5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1597];

5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1598];

5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1599]; and

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1600]; or a pharmaceutically acceptable salt thereof.

33 . The compound of claim 1 , wherein the compound of Formula I is selected from the group consisting of

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1601];

(R)-1-(4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [1602];

(R)-1-(4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1603];

(R)-1-(4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [1604];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1605];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1606];

5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1607];

3-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1608];

(1s,4s)-4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1609];

(1r,4r)-4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1610];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1611];

(R)-1-(4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropyrrolidin-1-yl)ethan-1-one [1612];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1613];

5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1614];

5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1615];

5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1616];

1-((3R,4S)-4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one [1617];

1-((3R,4S)-4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1618];

1-((3R,4S)-4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one [1619];

5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1620];

5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1621];

5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1622];

5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1623];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1624];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1625];

(R)-1-(4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [1626];

(R)-1-(4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one-2,2,2-d 3 [1627];

(R)-1-(4-((5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)-2-hydroxyethan-1-one [1628];

(R)—N-(3,3-difluoro-1-(methylsulfonyl)piperidin-4-yl)-5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1629];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1630];

5-(1-(3,3-difluorocyclobutyl)-1H-benzo[d][1,2,3]triazol-6-yl)-6-fluoro-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1631];

N-(3,3-dimethylcyclobutyl)-5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1632];

N-((1s,3s)-3-((5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclobutyl)cyclopropanecarboxamide [1633];

N-((1r,3r)-3-((5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclobutyl)cyclopropanecarboxamide [1634];

1-fluoro-N-((1s,3s)-3-((5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclobutyl)cyclopropane-1-carboxamide [1635];

1-fluoro-N-((1r,3r)-3-((5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclobutyl)cyclopropane-1-carboxamide [1636];

5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxy-N-(spiro[2.3]hexan-5-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1637];

5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxy-N-(spiro[3.3]heptan-2-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1638];

N-(6,6-difluorospiro[3.3]heptan-2-yl)-5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1639];

(1r,4r)-4-((5-(imidazo[1,2-a]pyrimidin-6-yl)-4-(methoxy-d 3 )pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1640];

(R)-cyclopropyl(3,3-difluoro-4-((5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)methanone [1641];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-6-fluoro-5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1642];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-6-fluoro-5-(imidazo[1,2-a]pyrimidin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1643];

N-(4,4-difluorocyclohexyl)-5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1644];

(1r,4r)-4-((5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1645];

5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1646];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1647];

(R)-1-(4-((5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [1648];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1649];

3-((5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-2,2-dimethylpropanenitrile [1650];

N-(4,4-difluorocyclohexyl)-5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1651];

(1s,4s)-4-((5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1652];

(1r,4r)-4-((5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-1-methylcyclohexan-1-ol [1653];

(R)—N-(4,4-difluoro-1-methylpyrrolidin-3-yl)-5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1654];

(R)—N-(4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1655];

(R)-1-(4-((5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-3,3-difluoropiperidin-1-yl)ethan-1-one [1656];

5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-6-fluoro-4-methoxy-N-(1-(oxetan-3-yl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1657];

5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-6-fluoro-N-((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1658];

5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-6-fluoro-N-((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1659];

5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-6-fluoro-N-((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1660];

5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-6-fluoro-N-((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1661];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1662];

(R)—N-(3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)-5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1663];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1664];

5-(3-(difluoromethyl)imidazo[1,2-a]pyrimidin-6-yl)-6-fluoro-4-methoxy-N-(2-oxaspiro[3.5]nonan-7-yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine [1665];

6-(2-((4,4-difluorocyclohexyl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1666];

6-(2-((4,4-dimethylcyclohexyl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1667];

6-(4-methoxy-2-(spiro[2.5]octan-6-ylamino)pyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1668];

6-(2-(((1r,4r)-4-hydroxy-4-methylcyclohexyl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1669];

(R)-6-(2-((3,3-difluoro-1-methylpiperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1670];

(R)-6-(2-((3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1671];

6-(2-((2-cyano-2-methylpropyl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1672];

6-(2-((4,4-dimethylcyclohexyl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1673];

6-(6-fluoro-4-methoxy-2-(spiro[2.5]octan-6-ylamino)pyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1674];

6-(2-((4,4-difluorocyclohexyl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1675];

6-(6-fluoro-2-(((1s,4s)-4-hydroxy-4-methylcyclohexyl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1676];

6-(6-fluoro-2-(((1r,4r)-4-hydroxy-4-methylcyclohexyl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1677];

(R)-6-(2-((4,4-difluoro-1-methylpyrrolidin-3-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1678];

(R)-6-(2-((4,4-difluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1679];

6-(6-fluoro-4-methoxy-2-((1-(oxetan-3-yl)piperidin-4-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1680];

6-(6-fluoro-2-(((3S,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1681];

6-(6-fluoro-2-(((3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1682];

6-(6-fluoro-2-(((3S,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1683];

6-(6-fluoro-2-(((3R,4S)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1684];

(R)-6-(2-((3,3-difluoro-1-methylpiperidin-4-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1685];

(R)-6-(2-((3,3-difluoro-1-(methyl-d 3 )piperidin-4-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1686];

(R)-6-(2-((3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1687];

6-(2-((2-oxaspiro[3.5]nonan-7-yl)amino)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide [1688];

(S)-1-((3R,4S)-3-fluoro-4-((4-methoxy-5-(quinolin-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)propan-2-ol [1689];

(R)-1-((3R,4S)-3-fluoro-4-((4-methoxy-5-(quinolin-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)propan-2-ol [1690];

(R)-2-((3R,4S)-3-fluoro-4-((4-methoxy-5-(quinolin-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)propan-1-ol [1691];

(S)-2-((3R,4S)-3-fluoro-4-((4-methoxy-5-(quinolin-6-yl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)propan-1-ol [1692];

(R)—N-(3,3-difluoropiperidin-4-yl)-5-(8-fluoroquinolin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1693];

(R)—N-(3,3-difluoro-1-methylpiperidin-4-yl)-5-(8-fluoroquinolin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1694];

(R)-1-(3,3-difluoro-4-((5-(8-fluoroquinolin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)piperidin-1-yl)ethan-1-one [1695];

(R)—N-(3,3-difluoro-1-(oxetan-3-yl)piperidin-4-yl)-5-(8-fluoroquinolin-6-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1696];

1-((3R,4S)-3-((5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-yl)amino)-4-fluoropyrrolidin-1-yl)ethan-1-one [1697];

5-(1-(2,2-difluoroethyl)-2-methyl-1H-benzo[d]imidazol-6-yl)-6-fluoro-N-((3R,4S)-4-fluoro-1-(oxetan-3-yl)pyrrolidin-3-yl)-4-methoxypyrrolo[2,1-f][1,2,4]triazin-2-amine [1698];

34 . A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

35 . A method of treating a disorder or disease in a patient, wherein the disorder or disease is selected from the group consisting of: a neurological disorder, diabetes, and cancer, the method comprising administering to the patient a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt, or the pharmaceutical composition of claim 34 .

36 . The method of claim 35 , wherein the disorder or disease is cancer.

37 . The method of claim 35 , wherein the disorder or disease is diabetes.

38 . The method of claim 35 , wherein the disorder or disease is a neurological disorder.

39 . The method of claim 36 , wherein the cancer is selected from the group consisting of: brain tumors, glioblastoma, ovarian, breast, head and neck squamous cell carcinoma, hepatocellular carcinoma, pancreatic cancer, acute lymphoblastic leukemia, acute megakaryoblastic leukemia, and chronic myeloid leukemia.

40 . The method of claim 38 , wherein the disorder or disease is a neurological disorder, wherein the neurological disorder is selected from the group consisting of: Alzheimer's disease, amyotrophic lateral sclerosis, CDKL5 deficiency disorder, Down syndrome, frontotemporal dementia with parkinsonism-17 (FTDP-17), Lewy body dementia, Parkinson's disease, Pick's disease, and additional diseases with pronounced neurodegeneration such as autism, dementia, epilepsy, Huntington's disease, multiple sclerosis; diseases and disorders associated with acquired brain injury such as chronic traumatic encephalopathy, traumatic brain injury, tumor, stroke, Pick disease, progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain disease, globular glial tauopathies, primary age-related tauopathy, neurofibrillary tangle dementia, chronic traumatic encephalopathy (CTE), frontotemporal lobar degeneration with tau inclusions (FTLD-tau), and aging-related tau astrogliopathy.

41 . The method of claim 40 , wherein the disorder or disease is Alzheimer's disease.

42 . The method of claim 35 , wherein the patient is a human.

Assignments (1)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 27, 2026

From: BIOSPLICE THERAPEUTICS, INC.

To: TENARX, INC.

Reel/Frame 074209/0693 →