NOVEL DPP1 INHIBITORS AND USES THEREOF

1 . A compound of Formula (I):

or a pharmaceutically acceptable salt or deuterated form thereof, wherein,

R 1 is

R 2 is

X 1 , X 2 and X 3 are independently O, S, NR 3 or CR 3 R 4 ;

each R 3 , R 4 and R 5 is independently H, F, Cl, Br, I or C 1 -C 6 alkyl;

each R 6 is independently H or C 1 -C 6 alkyl;

each Y is independently O, S, CHR 6 or NR 6 ;

m and m′ are each independently an integer from 0-3, and the total sum of m and m′ is ≤3;

each n, n′ and n″ is independently an integer from 0-3, and the total sum of n, n′ and n″ is ≤4; and

L is

provided that,

(i) when R 1 is

 and X 1 is —CH 2 —, then L and R 2 taken together, is not

(ii) when R 1 is

 then L and R 2 taken together, is not

(iii) when R 1 is

 and L is

 then R 2 is not

(iv) when R 1 is

 and L is

 then R 2 is not

(v) when R 1 is

 and L is

 then R 2 is not

(vi) when R 1 is

 and L is

 then R 2 is not

 and

(vii) when R 1 is

 and L is

 then R 2 is not

2 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof or deuterated form, wherein,

R 1 is

3 .- 16 . (canceled)

17 . The compound of claim 1 , or a pharmaceutically acceptable salt or deuterated form thereof, wherein X 1 is O or NH.

18 .- 22 . (canceled)

23 . The compound of claim 1 , or a pharmaceutically acceptable salt or deuterated form thereof, wherein the sum of n, n′ and n″ is 1, 2 or 3.

24 .- 44 . (canceled)

45 . The compound of claim 1 , or a pharmaceutically acceptable salt or deuterated form thereof, wherein R 2 is

46 . The compound of claim 1 , or a pharmaceutically acceptable salt or deuterated form thereof, wherein R 2 is

47 . (canceled)

48 . The compound of claim 1 , or a pharmaceutically acceptable salt or deuterated form thereof, wherein R 2 is

wherein Y is O, CHR 6 or NR 6 .

49 .- 51 . (canceled)

52 . The compound of claim 1 , or a pharmaceutically acceptable salt or deuterated form thereof, wherein R 2 is

53 .- 69 . (canceled)

70 . A compound of Formula (II), or a pharmaceutically acceptable salt or deuterated form thereof:

wherein,

R 1 is

each R 2 is independently H, F, Cl, Br, I or C 1 -C 6 alkyl; and

L is

 wherein the compound is not

71 .- 75 . (canceled)

76 . The compound of claim 70 , or a pharmaceutically acceptable salt or deuterated form thereof, wherein R 1 is

77 . The compound of claim 70 , or a pharmaceutically acceptable salt or deuterated form thereof, wherein R 1 is

78 . The compound of claim 70 , or a pharmaceutically acceptable salt or deuterated form thereof, wherein R 1 is

79 .- 148 . (canceled)

149 . The compound of claim 70 , or a pharmaceutically accept salt or deuterated form thereof, wherein the compound is:

150 .- 171 . (canceled)

172 . A compound of Formula (I-I):

or a pharmaceutically acceptable salt or deuterated form thereof, wherein,

R 1 is

R 2 is

X 1 , X 2 and X 3 are independently O, S, NR 3 or CR 3 R 4 ;

each R 3 , R 4 and R 5 is independently H, F, Cl, Br, I or C 1 -C 6 alkyl;

each R 6 is independently H or C 1 -C 6 alkyl;

each Y is independently O, S, CHR 6 or NR 6 ;

m and m′ are each independently an integer from 0-3, and the total sum of m and m′ is ≤3; and

L is

provided that, the compound is not:

173 . The compound of claim 172 , or a pharmaceutically acceptable salt or deuterated form thereof, having the following chemical structure:

174 . The compound of claim 172 , or a pharmaceutically acceptable salt or deuterated form thereof, having the following chemical structure:

175 . The compound of claim 172 , or a pharmaceutically acceptable salt or deuterated form thereof, having the following chemical structure:

wherein at least one R 5 is F.

176 . The compound of claim 172 , or a pharmaceutically acceptable salt or deuterated form thereof, having the following chemical structure:

wherein at least one R 5 is F.

177 . The compound of claim 172 , or a pharmaceutically acceptable salt or deuterated form thereof, wherein,

R 1 is

178 - 222 . (canceled)

223 . The compound of claim 1 , or a pharmaceutically acceptable salt or deuterated form thereof selected from one of the compounds of Table 3.

224 .- 328 . (canceled)

329 . A method for treating an obstructive disease of the airway in a patient in need thereof, comprising, administering to the patient for an administration period, a composition comprising an effective amount of a compound of claim 1 .

330 . A method for treating an obstructive disease of the airway in a patient in need thereof, comprising, administering to the patient for an administration period, a composition comprising an effective amount of a compound of claim 70 .

331 . A method for treating an obstructive disease of the airway in a patient in need thereof, comprising, administering to the patient for an administration period, a composition comprising an effective amount of a compound of claim 172 .