INSULIN INFUSION SET
Embodiments of devices and methods to maintain preservative concentration in a medication delivered using a medical device are provided. A barrier layer can be used to prevent migration of preservatives. A vent can be used to allow release of preservatives prior to delivery to the patient. An absorbent element can be used to maintain preservative concentration at a desired level. A filter can be used to capture particulates from the medication prior to delivery to a patient.
1 . An insulin delivery system comprising:
a reservoir configured to hold an insulin medication therein;
an infusion hub;
tubing fluidically connecting the insulin reservoir and the infusion hub;
a cannula configured to deliver the insulin medication to a patient; and
an absorbent element positioned within the delivery system and in fluidic contact with the insulin medication, the absorbent element configured to absorb and store preservatives from the insulin medication.
2 . The insulin delivery system of claim 1 , further comprising an impermeable backing layer adjacent to the absorbent element and configured to maintain the preservatives within the absorbent.
3 . The insulin delivery system of claim 1 , wherein the absorbent element comprises EVOH, silicone, a low-density polymer, a PEG block-copolymer (e.g., PETG), PET, nylon, a nylon block-copolymer, a polymeric foam, or a polymeric monolith.
4 . The insulin delivery system of claim 1 , wherein the absorbent element comprises a preservative capacity greater than a maximum concentration of preservative in the insulin medication.
5 . The insulin delivery system of claim 1 , wherein the absorbent element is further configured to release preservatives to the insulin medication after storing the preservatives.
6 . The insulin delivery system of claim 1 , wherein the absorbent element is configured to maintain the preservative concentration at a point of delivery to the patient at a concentration that minimizes local toxicity while maintaining insulin in a stable hexameric state.
7 . The insulin delivery system of claim 6 , wherein the absorbent element is configured to maintain the preservative concentration at a concentration of greater than about 1.25 mg/mL.
8 . The insulin delivery system of claim 6 , wherein the absorbent element is configured to maintain the preservative concentration at a concentration of about 1.15-1.75 mg/mL.
9 . The insulin delivery system of claim 6 , wherein the absorbent element is configured to maintain the preservative concentration at a concentration of about 1.25-1.50 mg/mL.
10 . The insulin delivery system of claim 1 , wherein the absorbent element comprises an interior layer of the tubing.
11 . The insulin delivery system of claim 1 , wherein at least a portion of the insulin delivery system includes a barrier layer configured to prevent migration of preservatives from the insulin medication.
12 . The insulin delivery system of claim 11 , wherein the tubing is a multi-layer tubing, and wherein the barrier layer is at least a portion of a layer of the multi-layer tubing.
13 . The insulin delivery system of claim 11 , wherein the tubing is a multi-layer tubing, and wherein the barrier layer forms an entire layer of the multi-layer tubing.
14 . The insulin delivery system of claim 11 , wherein the tubing comprises the barrier layer.
15 . The insulin delivery system of claim 11 , wherein the barrier layer comprises a coating on the tubing.
16 . The insulin delivery system of claim 11 , wherein the barrier layer comprises an inner layer of the tubing.
17 . The insulin delivery system of claim 11 , wherein the barrier layer comprises polyether block-amide, HDPE, polypropylene, PTFE, chloro- and fluorosilicones, hydrochloro-, hydrofluoro-, and perfluoro-polymers, chlorinated polymers (e.g. viton), metal-coated polymers (e.g., mylar), poly carbonate, organic or inorganic plasma-deposited coatings (e.g. PTFE, PVC, halogenated siloxanes, silicon suboxides), vapor-deposited coatings (such as nitrides, titanium nitride, fluorocarbons, metals), Kapton, or parylene.
18 . The insulin delivery system of claim 11 , further comprising a barrel connected to the cannula, and wherein the barrier layer is positioned on at least a portion of the barrel.
19 . The insulin delivery system of claim 11 , comprising a connector comprising the barrier layer.
20 . The insulin delivery system of claim 11 , wherein the barrier layer extends through an entire fluid path of the system.