IP Library › Granted Patent US 12,378,237
Granted Patent B2
US 12,378,237 · App. 19/018,773 · Granted Aug 5, 2025

Compounds as GLP-1R agonists

Inventors: Corey Reeves (Foster City, CA); F. Anthony Romero (Redwood City, CA); Christopher T. Jones (Foster City, CA); Martijn Fenaux (San Mateo, CA)
Assignee: Terns Pharmaceuticals, Inc.
C07D417/14A61P3/04A61P3/10
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Quick Facts
Patent No.
US 12,378,237
App. No.
19/018,773
Granted
Aug 5, 2025
Kind
B2
Abstract

The present application provides compounds that may be used as a glucagon-like peptide-1 receptors (GLP-1R) agonist, or pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions containing such compounds, or pharmaceutically acceptable salts thereof. Methods of preparing these compounds and compositions, and methods of using these compounds and compositions to treat or prevent a disease or a condition mediated by GLP-1R, are also provided.

Claims (29)

1. A compound selected from

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 , wherein the compound is

4. The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

5. The compound of claim 1 , wherein the compound is

6. The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

7. The compound of claim 1 , wherein the compound is

8. The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

9. The compound of claim 1 , wherein the compound is

10. The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

11. The compound of claim 1 , wherein the compound is

12. The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

13. The compound of claim 1 , wherein the compound is

14. The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

15. The compound of claim 1 , wherein the compound is

16. The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

17. The compound of claim 1 , wherein the compound is

18. The compound of claim 14 , wherein the compound is a meglumine salt of the compound.

19. A pharmaceutical composition comprising the compound of claim 18 and a pharmaceutically acceptable excipient.

20. A method of treating a disease mediated by glucagon-like peptide-1 receptor (GLP-1R) in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of the compound of claim 14 , or a pharmaceutically acceptable salt thereof.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 28, 2025
From: FENAUX, MARTIJN
To: TERNS PHARMACEUTICALS, INC.
Reel/Frame 070033/0975 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 28, 2025
From: REEVES, COREY; ROMERO, F. ANTHONY; JONES, CHRISTOPHER T.
To: TERNS, INC.
Reel/Frame 070033/0983 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 28, 2025
From: TERNS, INC.
To: TERNS PHARMACEUTICALS, INC.
Reel/Frame 070033/0992 →
Continuity (4)
Continuation 18956385 · Nov 22, 2024
Continuation 17954047 · Sep 27, 2022
Provisional Application 63261717 · Sep 27, 2021
Related Publication 20250145613A1 · May 8, 2025
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