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App. No. 19/025,271 · Confirmation No. 8081

MODIFIED RNA AGENTS WITH REDUCED OFF-TARGET EFFECT

Inventors: Mark K. SCHLEGEL, Maja JANAS, Vasant R. JADHAV, Muthiah MANOHARAN, Kallanthottathil G. RAJEEV, Muthusamy JAYARAMAN, Alexander V. KEL'IN, Shigeo MATSUDA, Klaus CHARISSE, Jayaprakash K. NAIR, Martin A. MAIER, Alfica SEHGAL, Christopher BROWN, Christopher THEILE, Stuart MILSTEIN

Applicant: ALNYLAM PHARMACEUTICALS, INC.

Response to Non-Final Office Action Entered and Forwarded to Examiner View Publication ↗

	Code	Description	Pages	PDF
2026-07-30	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	—	View
2026-07-30	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	1	View
2026-07-30	`CLM`	Claims	4	View
2026-07-30	`REM`	Applicant Arguments/Remarks Made in an Amendment	13	View
2026-07-30	`TRAN.LET`	Transmittal Letter	2	View
2026-07-30	`LET.`	Miscellaneous Incoming Letter	10	View
2026-07-30	`LET.`	Miscellaneous Incoming Letter	16	View
2026-07-30	`LET.`	Miscellaneous Incoming Letter	6	View
2026-07-30	`LET.`	Miscellaneous Incoming Letter	3	View
2026-07-30	`LET.`	Miscellaneous Incoming Letter	7	View
2026-07-30	`LET.`	Miscellaneous Incoming Letter	15	View
2026-07-30	`LET.`	Miscellaneous Incoming Letter	8	View
2026-07-30	`N417`	Electronic Filing System Acknowledgment Receipt	4	View
2026-04-30	`CTNF`	Non-Final Rejection	28	View
2026-04-30	`892`	List of references cited by examiner	1	View
2026-04-30	`SRFW`	Search information including classification, databases and other search related notes	1	View
2026-04-30	`1449`	List of References cited by applicant and considered by examiner	5	View
2026-04-30	`BIB`	Bibliographic Data Sheet	2	View
2026-04-30	`SRNT`	Examiner's search strategy and results	8	View
2026-04-30	`1449`	List of References cited by applicant and considered by examiner	10	View
2026-04-30	`1449`	List of References cited by applicant and considered by examiner	5	View
2026-04-30	`SRNT`	Examiner's search strategy and results	4	View
2025-10-28	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	5	View
2025-10-28	`TRAN.LET`	Transmittal Letter	1	View
2025-10-28	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2025-06-26	`NTC.PUB`	Notice of Publication	1	View
2025-03-25	`APP.FILE.REC`	Filing Receipt	4	View
2025-03-25	`WCLM`	Claims Worksheet (PTO-2022)	1	View
2025-03-25	`WFEE`	Fee Worksheet (SB06)	1	View
2025-03-19	`CRFE`	Sequence Listing in Computer Readable Format, No errors found	—	View
2025-03-19	`A.PE`	Preliminary Amendment	—	View
2025-03-19	`N417.PYMT`	Electronic Fee Payment	2	View
2025-03-19	`CRFS`	CRF Statement that Sequence Listing text file (CRF) and paper/pdf Sequence Listing are the same	1	View
2025-03-19	`REM`	Applicant Arguments/Remarks Made in an Amendment	187	View
2025-03-19	`A.PE`	Preliminary Amendment	1	View
2025-03-19	`SPEC`	Specification	1	View
2025-03-19	`CLM`	Claims	3	View
2025-03-19	`REM`	Applicant Arguments/Remarks Made in an Amendment	2	View
2025-03-19	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2025-03-19	`SPEC`	Specification	187	View
2025-03-19	`PEFR`	Applicant Response to Pre-Exam Formalities Notice	1	View
2025-03-19	`TRAN.LET`	Transmittal Letter	1	View
2025-03-19	`SEQ.XML`	Sequence Listing (XML File)	1	View
2025-03-19	`CRFE`	Sequence Listing in Computer Readable Format, No errors found	17	View
2025-02-19	`APP.FILE.REC`	Filing Receipt	4	View
2025-02-19	`WCLM`	Claims Worksheet (PTO-2022)	1	View
2025-02-19	`WFEE`	Fee Worksheet (SB06)	1	View
2025-02-19	`SEQ.REQ.DISC`	Requirements for Sequence Disclosure Notice	3	View
2025-02-19	`WELCOME.LET`	Welcome Letter from USPTO Director and Deputy Director	1	View
2025-01-23	`CRFD`	Sequence Listing in Computer Readable Format is Defective	—	View
2025-01-23	`CRFD`	Sequence Listing in Computer Readable Format is Defective	19	View
2025-01-16	`SPEC`	Specification	—	View
2025-01-16	`ADS`	Application Data Sheet	13	View
2025-01-16	`N417.PYMT`	Electronic Fee Payment	2	View
2025-01-16	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	5	View
2025-01-16	`DRW.NONBW`	Drawings-other than black and white line drawings	61	View
2025-01-16	`SPEC`	Specification	187	View
2025-01-16	`CLM`	Claims	5	View
2025-01-16	`ABST`	Abstract	1	View
2025-01-16	`OATH`	Oath or Declaration filed	16	View
2025-01-16	`TRAN.LET`	Transmittal Letter	1	View
2025-01-16	`N417`	Electronic Filing System Acknowledgment Receipt	4	View
2025-01-16	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	10	View
2025-01-16	`TRNA`	Transmittal of New Application	2	View
2025-01-16	`PA..`	Power of Attorney	1	View
2025-01-16	`CRFS`	CRF Statement that Sequence Listing text file (CRF) and paper/pdf Sequence Listing are the same	1	View
2025-01-16	`DRW.SUPP`	Drawings-black and white line and/or other drawings	—	View
2025-01-16	`DRW.SUPP`	Drawings-black and white line and/or other drawings	—	View
2025-01-16	`SCORE`	Placeholder sheet indicating presence of supplemental content in Supplemental Complex Repository for Examiners(SCORE)	1	View
2025-01-16	`SEQ.XML`	Sequence Listing (XML File)	1	View
2025-01-16	`SCORE`	Placeholder sheet indicating presence of supplemental content in Supplemental Complex Repository for Examiners(SCORE)	1	View

Inventors

Mark K. SCHLEGEL Cambridge, MA

Maja JANAS Cambridge, MA

Vasant R. JADHAV Cambridge, MA

Muthiah MANOHARAN Cambridge, MA

Kallanthottathil G. RAJEEV Cambridge, MA

Muthusamy JAYARAMAN Cambridge, MA

Alexander V. KEL'IN Cambridge, MA

Shigeo MATSUDA Cambridge, MA

Klaus CHARISSE Cambridge, MA

Jayaprakash K. NAIR Cambridge, MA

Martin A. MAIER Cambridge, MA

Alfica SEHGAL Cambridge, MA

Christopher BROWN Cambridge, MA

Christopher THEILE Cambridge, MA

Stuart MILSTEIN Cambridge, MA

Attorneys & Agents of Record

JOHN GATZ Reg. 41774 Attorney · NIXON PEABODY LLP

HARRY LEE Reg. 56814 Agent · NIXON PEABODY LLP

MARK FITZGERALD Reg. 45928 Attorney · NIXON PEABODY LLP

RONALD EISENSTEIN Reg. 30628 Attorney · NIXON PEABODY LLP

ELIZABETH BAIO Reg. 62744 Attorney · NIXON PEABODY LLP

DERRICK BRESKA Reg. 74266 Agent · NIXON PEABODY LLP

NICHOLAS BRESKA Reg. 78422 Attorney · NIXON PEABODY LLC

GEORGE DANDALIDES Reg. 69713 Attorney · FITCH, EVEN, TABIN & FLANNERY, LLP

DANIEL BURNHAM Reg. 39618 Attorney · NIXON PEABODY LLP

BRADLEY TAUB Reg. 67300 Attorney · NIXON PEABODY LLP

JENNIFER HAYES Reg. 50845 Attorney · NIXON PEABODY LLP

AMY SIEROCKI Reg. 54447 Attorney

SUWEI ZHU Reg. 75260 Agent · NIXON PEABODY LLP

JANET GARETTO Reg. 42568 Attorney · NIXON PEABODY LLP

ILYA MIROV Reg. 75286 Agent · NIXON PEABODY LLP

ANGELO CHRISTOPHER Reg. 81594 Attorney · NIXON PEABODY LLP

JOSHUA JAVITZ Reg. 77047 Attorney · DUANE MORRIS LLP

DAVID RESNICK Reg. 34235 Attorney · NIXON PEABODY LLP

SHANZHONG YUAN Reg. 77035 Attorney · NIXON PEABODY LLP

DAVID CROSBY Reg. 36400 Attorney · NIXON PEABODY LLP

ASHEESH PURI Reg. 53494 Attorney · MAYNARD NEXSEN LLP

MATTHEW WERBER Reg. 62056 Attorney · NIXON PEABODY LLP

RENJITH MATHEW Reg. 800137 Agent · NIXON PEABODY LLP

ELIZABETH LAUDADIO Reg. 83737 Agent · NIXON PEABODY LLP

SORINEL CIMPOES Reg. 48311 Attorney · NIXON PEABODY LLP

NICOLE KLING Reg. 71959 Agent · NIXON PEABODY LLP

WAYNE TANG Reg. 36028 Attorney · NIXON PEABODY LLP

JULIET DEFRANCISCO Reg. 70163 Attorney · NIXON PEABODY

IDONGESIT EBONG Reg. 74272 Attorney · NIXON PEABODY LLP

ALLISON STRONG Reg. 79349 Attorney · NIXON PEABODY LLP

SASHA RAO Reg. 57017 Attorney

AYHAN MERTOGUL Reg. 63977 Attorney · NIXON PEABODY LLP

JAMES COOKE Reg. 69338 Attorney · NIXON PEABODY LLP

BRANDON STROY Reg. 73166 Attorney

DAVID MAY Reg. 58760 Attorney · NIXON PEABODY, LLP

LINDA HUBER Reg. 56461 Attorney · NIXON PEABODY LLP

ALISSA YOUNG Reg. 81141 Attorney · NIXON PEABODY LLP

THOMAS PAVELKO Reg. 31689 Attorney · NIXON PEABODY LLP

JEANNE JODOIN Reg. 80219 Agent · NIXON PEABODY, LLP

RAVINDERJIT BRAICH Reg. 81195 Agent · NIXON PEABODY LLP

SETH LEVY Reg. 44869 Attorney · NIXON PEABODY LLP

SUMIYO ONDA Reg. 62166 Agent · NIXON PEABODY LLP

JASON KUNZE Reg. 65691 Attorney · NIXON PEABODY LLP

JEFFREY COSTELLIA Reg. 35483 Attorney · NIXON PEABODY LLP

SHAYNE HUFF Reg. 44784 Agent · NIXON PEABODY LLP

MARY SYLVIA Reg. 37156 Attorney · WILEY REIN LLP

COLLEEN MCKIERNAN Reg. 48570 Agent · ALNYLAM PHARMACEUTICALS, INC.

STEVEN BOSSONE Reg. 51196 Attorney · ALNYLAM PHARMACEUTICALS

JEFFREY KOPACZ Reg. 54744 Agent · ALNYLAM PHARMACEUTICALS

SUANNE NAKAJIMA Reg. 63207 Attorney · AERA THERAPEUTICS

SARAH FENDRICK Reg. 66262 Attorney · ALNYLAM PHARMACEUTICALS

Classification

USPC 514/44R

A61K31/713 C12N15/113 A61P43/00 C12N2310/14 C12N2310/31 C12N2310/315 C12N2310/322 C12N2310/3231 C12N2310/351 C12N2310/3533 C12N2320/53

Prosecution

Examiner: MCKILLOP, JOHN CHARLES
Art Unit: 1637
Customer No.: 90162
Docket No.: 051058-088343USC2
Confirmation No.: 8081

Publication

Pub. No.: US20250205272A1
Pub. Date: 2025-06-26

Parent is a Continuation of

→

App. 17/937,256

Filed 2022-09-30 · Non Final Action Mailed

Parent is a Continuation of

→

App. 16/461,523 · US 11,504,391

Filed 2019-05-16 · Patented Case

Parent PCT is a National Stage Entry of

→

PCT/US2017/063078

Filed 2017-11-22 · Response to Non-Final Office Action Entered and Forwarded to Examiner

Parent Claims priority from a provisional application

→

App. 62/425,907

Filed 2016-11-23 · Provisional Application Expired

Parent Claims priority from a provisional application

→

App. 62/548,589

Filed 2017-08-22 · Provisional Application Expired

Parent Claims priority from a provisional application

→

App. 62/561,514

Filed 2017-09-21 · Provisional Application Expired

BANK OF AMERICA, N.A.

from ALNYLAM PHARMACEUTICALS, INC., SIRNA THERAPEUTICS, INC.

SECURITY INTEREST Recorded 2025-10-01

072996/0337 →

ALNYLAM PHARMACEUTICALS, INC.

from RAJEEV, KALLANTHOTTATHIL G., JADHAV, VASANT R., MANOHARAN, MUTHIAH, MILSTEIN, STUART, MAIER, MARTIN A., JAYARAMAN, MUTHUSAMY, SEHGAL, ALFICA, FOSTER, DONALD, CHARISSE, KLAUS, SCHLEGEL, MARK K., JANAS, MAJA, MATSUDA, SHIGEO, NAIR, JAYAPRAKASH K., BROWN, CHRISTOPHER, THEILE, CHRISTOPHER, KEL'IN, ALEXANDER V.

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded 2025-04-23

070919/0220 →

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Quick Facts

App. No.: 19/025,271
Filed: 2025-01-16
Pub. No.: US20250205272A1
Examiner: MCKILLOP, JOHN CHARLES
Art Unit: 1637

External Links

USPTO Patent Center↗ Pre-Grant Publication PDF↗