IP Library › Patent Application 19028712
Patent Application
App. No. 19/028,712

METHODS FOR MAKING ULTRASOUND CONTRAST AGENTS

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Quick Facts
Patent No.
US None
App. No.
19/028,712
Abstract

Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.

Claims (20)

1 - 9 . (canceled)

10 . A method for preparing a phospholipid suspension, comprising

selecting a MPEG5000-DPPE stock characterized as having no or low calcium concentration,

combining said MPEG5000-DPPE stock, a DPPA stock, a DPPC stock and a non-aqueous solvent to form a phospholipid solution, and

combining the phospholipid solution with an aqueous solvent to form a phospholipid suspension.

11 . A method for preparing a phospholipid suspension, comprising

combining a MPEG5000-DPPE stock, a DPPA stock, a DPPC stock and a non-aqueous solvent to form a phospholipid solution characterized as having no or low calcium concentration, and

combining the phospholipid solution with an aqueous solvent to form a phospholipid suspension.

12 . A method for imaging a subject comprising

combining a phospholipid suspension with a perfluorocarbon gas to form an ultrasound contrast agent comprising phospholipid-encapsulated gas microspheres,

administering the ultrasound contrast agent to a subject, and

obtaining one or more contrast-enhanced ultrasound contrast images of the subject, wherein the phospholipid suspension is prepared by the method of claim 10 .

13 - 14 . (canceled)

15 . A method for imaging a subject comprising

combining a phospholipid suspension with a perfluorocarbon gas to form an ultrasound contrast agent comprising phospholipid-encapsulated gas microspheres,

administering the ultrasound contrast agent to a subject, and

obtaining one or more contrast-enhanced ultrasound contrast images of the subject, wherein the phospholipid suspension is prepared by a method comprising

combining a MPEG5000-DPPE stock, a DPPA stock, a DPPC stock and a non-aqueous solvent to form a phospholipid solution characterized as having no or low calcium concentration, and

combining the phospholipid solution with an aqueous solvent to form a phospholipid suspension.

16 - 27 . (canceled)