IP Library › Patent Application 19028806
Patent Application
App. No. 19/028,806

LIPID-ENCAPSULATED GAS MICROSPHERE COMPOSITIONS AND RELATED METHODS

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Quick Facts
Patent No.
US None
App. No.
19/028,806
Abstract

The invention provides, inter alia, improved lipid formulations used to generate lipid-encapsulated gas microspheres, and methods of their use.

Claims (29)

1 . A composition comprising

a non-aqueous mixture comprising DPPA, DPPC and PEG5000-DPPE in propylene glycol, or propylene glycol and glycerol, or glycerol, and

a perfluorocarbon gas.

2 - 27 . (canceled)

28 . The composition of claim 1 , wherein the composition is provided in a single chamber container.

29 . The composition of claim 1 , wherein the composition is provided in a multiple chamber container.

30 . A container comprising the composition of claim 1 .

31 . The container of claim 30 , wherein the container is a single chamber container.

32 . The container of claim 30 , wherein the container comprises a first and a second chamber, and wherein the non-aqueous mixture is in the first chamber and the perfluorocarbon gas is in the second chamber.

33 . A container comprising the composition of claim 1 in a first chamber, and propylene glycol or glycerol or propylene glycol and glycerol in a second chamber.

34 . A container comprising the composition of claim 1 in a first chamber and an aqueous diluent in a second chamber.

35 . The container of claim 34 , wherein the aqueous diluent is an aqueous saline solution.

36 . The container of claim 34 , wherein the aqueous diluent is an aqueous buffered saline solution.

37 - 38 . (canceled)

39 . A composition comprising

a mixture of DPPA, DPPC and PEG5000-DPPE in solid form, and

a perfluorocarbon gas.

40 . A container comprising the composition of claim 39 .

41 . The container of claim 40 , having a single chamber.

42 . The container of claim 40 , having a first chamber, wherein the composition is present in the first chamber of the container.

43 . The container of claim 40 , having two chambers, wherein a first chamber comprises DPPA, DPPC and PEG5000-DPPE in solid form, and a second chamber comprises the perfluorocarbon gas.

44 - 49 . (canceled)

50 . A composition comprising

lipid-encapsulated gas microspheres comprising DPPA, DPPC and PEG5000-DPPE and perfluorocarbon gas, in a non-aqueous solution comprising propylene glycol and glycerol.

51 - 87 . (canceled)

88 . A method of forming an ultrasound contrast agent comprising

adding glycerol and/or an aqueous diluent to the composition of claim 1 , and

then activating the composition to form lipid-encapsulated gas microspheres.

89 - 99 . (canceled)