DRUG ELUTING OCULAR IMPLANTS AND METHODS OF TREATING AN OCULAR DISORDER
Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allows for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.
1 - 20 . (canceled)
21 . A drug delivery ocular implant comprising:
an implant body having an interior space;
travoprost contained within the interior space, the implant body having a semi-permeable or permeable region that is semi-permeable or permeable to the travoprost; and
an anchor extending along a longitudinal axis of the drug delivery ocular implant and distally from a distal end, the anchor configured to affix the implant into an ocular tissue, wherein at least a portion of the anchor is configured to extend into the ocular tissue.
22 . The drug delivery ocular implant of claim 21 , further comprising a cap positioned near an open end of the implant body.
23 . The drug delivery ocular implant of claim 21 , wherein the travoprost is configured to elute from the interior space for at least 6 months.
24 . The drug delivery ocular implant of claim 21 , wherein the travoprost is configured to elute from the interior space for at least 12 months.
25 . The drug delivery ocular implant of claim 21 , wherein the travoprost is configured to elute from the interior space for at least 24 months.
26 . The drug delivery ocular implant of claim 21 , further comprising a flange extending radially from a sidewall of the implant body.
27 . The drug delivery ocular implant of claim 21 , wherein the implant body comprises a diameter of between 100 microns and 600 microns.
28 . The drug delivery ocular implant of claim 21 , wherein the ocular tissue is scleral tissue.
29 . The drug delivery ocular implant of claim 21 , wherein at least a portion of the implant body comprises titanium.
30 . A drug delivery ocular implant comprising:
an implant body having an interior space;
a drug contained within the interior space;
a semi-permeable or permeable region that is semi-permeable or permeable to the drug; and
an anchor extending along a longitudinal axis of the drug delivery ocular implant and distally from a distal end, the anchor configured to affix the implant into an ocular tissue.
31 . The drug delivery ocular implant of claim 30 , wherein the semi-permeable or permeable region comprises a membrane.
32 . The drug delivery ocular implant of claim 30 , further comprising a cap positioned near an open end of the implant body.
33 . The drug delivery ocular implant of claim 30 , wherein the drug is configured to elute from the interior space for at least 6 months.
34 . The drug delivery ocular implant of claim 30 , wherein the drug is configured to elute from the interior space for at least 12 months.
35 . The drug delivery ocular implant of claim 30 , wherein the drug is configured to elute from the interior space for at least 24 months.
36 . The drug delivery ocular implant of claim 30 , wherein the implant body comprises a diameter of between 100 microns and 600 microns.
37 . The drug delivery ocular implant of claim 30 , wherein the ocular tissue is scleral tissue.
38 . The drug delivery ocular implant of claim 30 , wherein the drug is travoprost.
39 . The drug delivery ocular implant of claim 30 , wherein at least a portion of the implant body comprises titanium.
40 . The drug delivery ocular implant of claim 30 , wherein the drug comprises one or more of an active drug or a prodrug or a salt of the active drug.