IP Library Granted Patent US 12,527,621
Granted Patent B1
US 12,527,621 · App. 19/037,701 · Granted Jan 20, 2026

Apparatus and method for determining a tissue susceptibility value

Inventors: Animesh Agarwal (San Mateo, CA); Suthirth Vaidya (Bengaluru, IN); Rakesh Barve (Bengaluru, IN)
Assignee: Anumana, Inc.
A61B18/1492A61B5/318G06T7/0012A61B2018/00577A61B2018/00642G06T2207/10081G06T2207/10088G06T2207/20081
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Quick Facts
Patent No.
US 12,527,621
App. No.
19/037,701
Granted
Jan 20, 2026
Kind
B1
Abstract

An apparatus and method for determining a tissue susceptibility value from medical data. The apparatus includes an imaging device, wherein the imaging device is configured to detect an image of a subject, wherein the subject receives tissue ablation, a memory, and at least a processor communicatively connected to the memory, wherein the memory contains instructions configuring the at least a processor to receive the image of the subject, generate a tissue susceptibility prediction model, wherein the tissue susceptibility prediction model is configured to receive, as input, the image of the subject, and determine a tissue susceptibility value as a function of the image, wherein the tissue susceptibility value defines a susceptibility of a tissue to the tissue ablation, display, using a downstream device, the tissue susceptibility value through a graphical user interface.

Claims (43)

1 . An apparatus for determining a tissue susceptibility value, wherein the apparatus comprises:

an imaging device, wherein the imaging device is configured to detect an image of a subject, wherein the subject receives tissue ablation;

a memory; and

at least a processor communicatively connected to the memory, wherein the memory contains instructions configuring the at least a processor to:

receive the image of the subject;

generate a tissue susceptibility prediction model, wherein the tissue susceptibility prediction model is configured to:

receive, as input, the image of the subject; and

determine a tissue susceptibility value as a function of the image, wherein the tissue susceptibility value defines a susceptibility of a tissue to the tissue ablation;

generate a dose-dependent graph as a function of the tissue susceptibility value, wherein the dose-dependent graph comprises an X-axis denoting modulation and a Y-axis denoting tissue resistance; and

display, using a downstream device, the tissue susceptibility value through a graphical user interface.

2 . The apparatus of claim 1 , wherein receiving the image of the subject comprises receiving heterogeneous data comprising the image of the subject and electrocardiogram data.

3 . The apparatus of claim 2 , wherein:

the memory contains instructions further configuring the at least a processor to train the tissue susceptibility prediction model using training data comprising pre-ablation image data correlated to post-ablation resistance data, wherein the pre-ablation image data comprises pre-ablation magnetic resonance imaging data and pre-ablation computed tomography data;

receiving the image of the subject comprises receiving magnetic resonance imaging data and computed tomography data; and

the tissue susceptibility prediction model is configured to receive the magnetic resonance imaging data and the computed tomography data as input.

4 . The apparatus of claim 1 , wherein the apparatus is configured to receive a modulation data from an ablation probe.

5 . The apparatus of claim 4 , wherein the at least a processor is further configured to:

plot the modulation data on the dose-dependent graph; and

display the dose-dependent graph.

6 . The apparatus of claim 1 , wherein the tissue susceptibility model is trained using training data comprising annotated data, wherein the annotated data comprises pre-ablation image data associated with post-ablation resistance data.

7 . The apparatus of claim 1 , wherein the tissue susceptibility model comprises a convolutional neural network configured to predict a score.

8 . The apparatus of claim 7 , wherein the graphical user interface comprises a visualization tool configured to generate a visual element associated with the score.

9 . The apparatus of claim 8 , wherein generating the visual element comprises utilizing a color scale corresponding to a threshold based on the tissue susceptibility value.

10 . A method for determining a tissue susceptibility value, wherein the method comprises:

receiving, using at least a processor, an image of a subject, wherein the subject receives tissue ablation;

generating, using at least a processor, a tissue susceptibility prediction model, wherein the tissue susceptibility prediction model is configured to:

receive, as input, the image of the subject; and

determine a tissue susceptibility value as a function of the image, wherein the tissue susceptibility value defines a susceptibility of a tissue to the tissue ablation;

generate a dose-dependent graph as a function of the tissue susceptibility value, wherein the dose-dependent graph comprises an X-axis denoting modulation and a Y-axis denoting tissue resistance; and

displaying, using a downstream device, the tissue susceptibility value through a graphical user interface.

11 . The method of claim 10 , wherein receiving the image of the subject comprises receiving heterogeneous data comprising the image of the subject and electrocardiogram data.

12 . The method of claim 11 , wherein:

a memory contains instructions further configuring the at least a processor to train the tissue susceptibility prediction model using training data comprising pre-ablation image data correlated to post-ablation resistance data, wherein the pre-ablation image data comprises pre-ablation magnetic resonance imaging data and pre-ablation computed tomography data;

receiving the image of the subject comprises receiving magnetic resonance imaging data and computed tomography data; and

the tissue susceptibility prediction model is configured to receive the magnetic resonance imaging data and the computed tomography data as input.

13 . The method of claim 10 further configured to receive a modulation data from an ablation probe.

14 . The method of claim 13 further configured to:

plot the modulation data on the dose-dependent graph; and

display the dose-dependent graph.

15 . The method of claim 10 , wherein the tissue susceptibility model is trained using training data comprising annotated data, wherein the annotated data comprises pre-ablation image data associated with post-ablation resistance data.

16 . The method of claim 10 , wherein the tissue susceptibility model comprises a convolutional neural network configured to predict a score.

17 . The method of claim 16 , wherein the graphical user interface comprises a visualization tool configured to generate a visual element associated with the score.

18 . The method of claim 17 , wherein generating the visual element comprises utilizing a color scale corresponding to a threshold based on the tissue susceptibility value.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 7, 2025
From: AGARWAL, ANIMESH; VAIDYA, SUTHIRTH; BARVE, RAKESH
To: ANUMANA, INC.
Reel/Frame 070435/0848 →
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