POWDER SPRAY DISPENSER FOR COMMINUTED ECM
Disclosed are powder spray dispensing devices for comminuted extracellular matrix powder materials, and terminally sterilized products for providing such devices, as well as related methods for manufacture and use. A powder spray dispensing device can include a squeeze pump bottle having a bottle body defining a bottle opening and an interior chamber. A dry collagenous extracellular matrix material powder is received in the interior chamber of the squeeze pump bottle, and a cap is fitted over the bottle opening. The cap has a dispensing spout fluidly communicating with the bottle opening and having a spout lumen, desirably of decreasing diameter in a direction extending away from the bottle opening. Amounts of the dry, comminuted collagenous extracellular matrix material powder are ejectable as a powder spray out of the spout opening by a pumping inward deflection of at least one wall portion of the squeeze pump bottle that causes a gas pressure impulse to travel from the interior chamber of the squeeze pump bottle through the spout lumen and out the spout opening.
1 - 17 . (canceled)
18 . A device for dispensing a dry, comminuted collagenous extracellular matrix powder, comprising:
a squeeze pump bottle having a bottle body defining a bottle opening and an interior chamber;
a dry, comminuted collagenous extracellular matrix material powder received in the interior chamber of the squeeze pump bottle; and
a cap attached to the bottle and positioned over the bottle opening, the cap having a dispensing spout fluidly communicating with the bottle opening, the dispensing spout defining a spout lumen and a spout opening;
wherein amounts of the dry collagenous extracellular matrix material powder are ejectable as a powder spray out of the spout opening by a pumping inward deflection of at least one wall portion of the squeeze pump bottle that causes a gas pressure impulse to travel from the interior chamber of the squeeze pump bottle through the spout lumen and out the spout opening.
19 . The device of claim 18 , wherein the dry, comminuted collagenous extracellular matrix powder has an average particle size in the range of about 75μ to about 200μ.
20 . The device of claim 18 , wherein particles of the dry, comminuted collagenous ECM powder have an external distribution of exposed individualized fibers.
21 . The device of claim 18 , wherein the dry, comminuted collagenous ECM powder is provided as a volume that occupies no more than about 50% of a volume of the interior chamber of the squeeze pump bottle.
22 . The device of claim 18 , wherein the spout lumen has a decreasing diameter in a direction extending away from the bottle opening when attached to the bottle.
23 . The device of claim 18 , wherein the dry, comminuted collagenous ECM powder has been sterilized with ethylene oxide.
24 . The device of claim 18 , wherein the dry, comminuted collagenous ECM powder comprises growth factors, proteoglycans and glycosaminoglycans native to an animal source tissue for the dry, comminuted collagenous ECM powder.
25 . The device of claim 18 , wherein the dry, comminuted collagenous ECM powder has an mean particle diameter of greater than about 75μ.
26 . The device of claim 18 , wherein the dry, comminuted collagenous ECM powder has a mean particle diameter of greater than about 100μ.
27 . The device of claim 18 , wherein the dry, comminuted ECM powder has a particle mode of about 100μ or greater.
28 . The device of claim 27 , wherein the dry, comminuted ECM powder has a particle mode in the range of about 100μ to about 250μ.
29 . The device of claim 18 , wherein at least 50% by volume of the particles of the dry, comminuted ECM powder have a maximum diameter of greater than about 75μ.
30 . The device of claim 18 , wherein at least 50% by volume of the particles of the dry, comminuted ECM powder have a maximum diameter of greater than about 90μ.
31 . The device of claim 18 , wherein less than 10% by volume of the particles of the dry, comminuted ECM powder have a maximum diameter of less than about 10μ.
32 . The device of claim 18 , wherein less than 10% by volume of the particles of the dry, comminuted ECM powder have a maximum diameter of less than about 20μ.
33 . A method for applying a collagenous extracellular matrix material to tissue of a patient, comprising:
providing a device according to claim 18 ; and
inwardly deflecting the at least one wall portion of the squeeze pump bottle to cause a gas pressure impulse to travel from the interior chamber of the squeeze pump bottle, through the spout lumen, and out the spout opening, to thereby eject an amount of the dry collagenous ECM powder as a powder spray out of the spout opening and onto the tissue of the patient.
34 . (canceled)