IP Library › Granted Patent US 12,453,756
Granted Patent B2
US 12,453,756 · App. 19/042,887 · Granted Oct 28, 2025

GIP/GLP1 agonist compositions

Inventors: Vincent John Corvari (Carmel, IN); Christopher Sears Minie (Zionsville, IN); Dinesh Shyamdeo Mishra (Carmel, IN); Ken Kangyi Qian (Carmel, IN)
Assignee: ELI LILLY AND COMPANY
A61K38/16A61K9/0019A61K47/02A61K47/10A61M5/20
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Quick Facts
Patent No.
US 12,453,756
App. No.
19/042,887
Granted
Oct 28, 2025
Kind
B2
Abstract

A composition of tirzepatide, comprising an agent selected from NaCl and propylene glycol; and dibasic sodium phosphate is provided.

Claims (17)

1 . A pharmaceutical composition comprising:

(a) tirzepatide, or a pharmaceutically acceptable salt thereof; and

(b) from about 6.2 mg/mL to about 9.5 mg/mL of NaCl,

wherein the pharmaceutical composition has a pH of from about 6.5 to about 7.5.

2 . The pharmaceutical composition of claim 1 , wherein the composition comprises from about 7.0 mg/mL to about 9.0 mg/ml of NaCl.

3 . The pharmaceutical composition of claim 1 , wherein the composition has a pH of from about 6.7 to about 7.3.

4 . The pharmaceutical composition of claim 1 , wherein the composition comprises from about 5 mg/mL to about 30 mg/mL of tirzepatide, or a pharmaceutically acceptable salt thereof.

5 . The pharmaceutical composition of claim 1 , wherein the composition further comprises a preservative selected from the group consisting of metacresol and phenol.

6 . The pharmaceutical composition of claim 1 , wherein the composition is administered using an automatic injection apparatus.

7 . The pharmaceutical composition of claim 2 , wherein the composition comprises about 8.2 mg/ml of NaCl.

8 . The pharmaceutical composition of claim 4 , wherein the composition comprises 5 mg/mL, 10 mg/mL, 15 mg/mL, 20 mg/mL, 25 mg/mL, or 30 mg/mL of tirzepatide, or a pharmaceutically acceptable salt thereof.

9 . The pharmaceutical composition of claim 5 , wherein the preservative is metacresol.

10 . The pharmaceutical composition of claim 5 , wherein the preservative is phenol.

11 . The pharmaceutical composition of claim 9 , wherein the composition comprises from about 2.0 mg/mL to about 4.0 mg/mL of metacresol.

12 . The pharmaceutical composition of claim 11 , wherein the composition comprises about 3.15 mg/mL of metacresol.

13 . The pharmaceutical composition of claim 10 , wherein the composition comprises from about 3.0 mg/mL to about 7.0 mg/ml of phenol.

14 . The pharmaceutical composition of claim 13 , wherein the composition comprises about 5.0 mg/mL of phenol.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 31, 2025
From: CORVARI, VINCENT JOHN; MINIE, CHRISTOPHER SEARS; MISHRA, DINESH SHYANDEO; QIAN, KEN KANGYI
To: ELI LILLY AND COMPANY
Reel/Frame 070079/0648 →
Continuity (5)
Continuation 18422177 · Jan 25, 2024
Continuation 17741067 · May 10, 2022
Continuation 16441329 · Jun 14, 2019
Provisional Application 62688632 · Jun 22, 2018
Related Publication 20250186544A1 · Jun 12, 2025
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Cited By (1)
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