DUAL PATHWAY THERAPEUTIC AGENT DELIVERY
Methods are provided for delivering a treatment therapy to treat an organ diagnosed with a disease state. The methods include delivering a first therapeutic agent into systemic circulation at a first flow rate, and delivering a second therapeutic agent directly into a vessel feeding the organ at a higher second flow rate than the first flow rate in a manner that prevents the second treatment agent from circulating systemically.
1 . A method of delivering a treatment therapy to a patient, the treatment therapy to treat an organ diagnosed with a disease state, comprising:
a) delivering a first therapeutic agent into systemic circulation at a first flow rate; and
b) delivering a second therapeutic agent directly into or adjacent a vessel extending from the organ at a higher second flow rate than the first flow rate in a manner that provides targeted treatment of the organ.
2 . The method according to claim 1 , wherein the disease state is a tumor.
3 . The method according to claim 2 , wherein the organ is the pancreas.
4 . The method according to claim 1 , wherein the first therapeutic agent is delivered into the superior vena cava, and the vessel is the portal vein.
5 . The method according to claim 1 , further comprising preventing retrograde flow in the vessel of the organ during delivering the second therapeutic agent.
6 . The method according to claim 5 , wherein retrograde flow is automatically and dynamically prevented.
7 . The method according to claim 5 , wherein the retrograde flow is prevented by an occlusion device.
8 . The method according to claim 1 , wherein the second therapeutic agent upon delivery is prevented from systemic circulation.
9 . The method according to claim 1 , wherein the second therapeutic agent, upon delivery, is initially isolated in a target region.
10 . The method according to claim 1 , further comprising before delivering the second therapeutic agent, monitoring a systemic pressure of the venous system, and adjusting the second flow rate based on the monitored systemic pressure.
11 . The method according to claim 1 , wherein delivering the first and second therapeutic agents occur through separate catheters.
12 . The method according to claim 1 , further comprising after delivering the second therapeutic agent, injecting a bolus of another liquid into the vessel to cause the second therapeutic agent to be pushed deeper into the organ.
13 . The method according to claim 12 , wherein the bolus is saline.
14 . A method of delivering a treatment therapy to a patient, the treatment therapy to treat an organ diagnosed with a disease state, comprising:
a) infusing a first therapeutic into systemic circulation at a first flow rate; and
b) injecting a second therapeutic agent directly into or adjacent a vessel extending from the organ at a higher second flow rate than the first flow rate in a manner that provides targeted treatment of the organ.
15 . The method according to claim 14 , wherein the disease state is a tumor.
16 . The method according to claim 14 , wherein the organ is the pancreas.
17 . The method according to claim 14 , wherein the first therapeutic agent is infused into the superior vena cava, and the vessel is the portal vein.
18 . The method according to claim 14 , further comprising preventing retrograde flow in the vessel of the organ during delivering the second therapeutic agent.
19 . The method according to claim 18 , wherein retrograde flow is automatically and dynamically prevented.
20 . The method according to claim 18 , wherein the retrograde flow is prevented by an occlusion device.
21 . The method according to claim 14 , further comprising before injecting the second therapeutic agent, monitoring a systemic pressure of the venous system, and adjusting the second flow rate based on the monitored systemic pressure.
22 . The method according to claim 14 , wherein the second therapeutic agent upon delivery is prevented from systemic circulation.
23 . The method according to claim 14 , wherein the second therapeutic agent, upon delivery, is initially isolated in a target region.
24 . The method according to claim 14 , wherein delivering the first and second therapeutic agents occur through separate catheters.
25 . The method according to claim 14 , further comprising after injecting the second therapeutic agent, injecting a bolus of another liquid into the vessel to cause the second therapeutic agent to be pushed deeper into the organ.
26 . The method according to claim 25 , wherein the bolus is saline.
27 . A method of delivering a treatment therapy to a patient, the treatment therapy to treat an organ diagnosed with a disease state, comprising:
a) delivering a first therapeutic into systemic circulation at a first flow rate; and
b) delivering a second therapeutic agent directly into or adjacent a vessel extending from the organ at a higher second flow rate than the first flow rate, wherein retrograde flow in the vessel of the organ is prevented during the delivering of the second therapeutic agent.
28 . The method according to claim 27 , wherein the disease state is a tumor.
29 . The method according to claim 27 , wherein the organ is the pancreas.
30 . The method according to claim 27 , wherein the first therapeutic agent is delivered into the superior vena cava, and the vessel is the portal vein.
31 . The method according to claim 27 , wherein retrograde flow in the major vessel is automatically and dynamically prevented.
32 . The method according to claim 27 , wherein the retrograde flow is prevented by an occlusion device.
33 . The method according to claim 27 , further comprising before delivering the second therapeutic agent, monitoring a systemic pressure of the venous system, and adjusting the second flow rate based on the monitored systemic pressure.
34 . The method according to claim 27 , wherein delivering the first and second therapeutic agents occur through separate catheters.
35 . The method according to claim 27 , further comprising after delivering the second therapeutic agent, injecting a bolus of another liquid into the vessel to cause the second therapeutic agent to be pushed deeper into the organ.
36 . The method according to claim 35 , wherein the bolus is saline.
37 . The method according to claim 27 , wherein the second therapeutic agent upon delivery is prevented from systemic circulation.
38 . The method according to claim 27 , wherein the second therapeutic agent, upon delivery, is initially isolated in a target region.