NANOMATERIALS COMPRISING A BIODEGRADABLE FEATURE
The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.
1 - 30 . (canceled)
31 . The compound of Formula (VI),
or pharmaceutically acceptable salt thereof,
wherein:
n is 1, 2, 3, or 4;
L 2 is an optionally substituted bivalent saturated straight or branched C 4 -C 8 hydrocarbon chain;
R 1 is a saturated or unsaturated, straight or branched C 6 -C 20 hydrocarbon chain,
A 1 is C 6 -C 12 aliphatic;
A 2 is C 6 -C 12 aliphatic;
X 1 is a covalent bond or —O—; and
—X 2 —X 3 selected from the group consisting of
32 . The compound of Formula (IV) in claim 31 , wherein n is 2.
33 . The compound of Formula (VI) in claim 31 , wherein L 2 is selected from the group consisting of:
optionally substituted —CH 2 CH 2 CH 2 CH 2 —,
optionally substituted —CH 2 CH 2 CH 2 CH 2 CH 2 —,
optionally substituted —CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 —, and
optionally substituted —CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 —.
34 . The compound of Formula (VI) in claim 33 , wherein L 2 is optionally substituted —CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 —.
35 . The compound of Formula (VI) in claim 31 , wherein R 1 is a saturated or unsaturated, straight or branched C 9 -C 15 hydrocarbon chain.
36 . The compound of Formula (VI) in claim 35 , wherein R 1 is a saturated or unsaturated, straight or branched C 9 hydrocarbon chain.
37 . The compound of Formula (VI) in claim 35 , wherein R 1 is a saturated or unsaturated, straight or branched C 11 hydrocarbon chain.
38 . The compound of Formula (VI) in claim 35 , wherein R 1 is a saturated or unsaturated, straight or branched C 13 hydrocarbon chain.