MIXTURE OF STABILIZED STANNOUS IONS COMPLEX FOR HIGH-WATER CONTENT ORAL CARE PRODUCT

1 . A method of forming a stable stannous ion complex or an oral care product, comprising:

forming a first aqueous phase by mixing water, stannous ions, and a chelating agent;

forming an oil phase by mixing an oil and a first emulsifier;

wherein a mass ratio of the oil to the first emulsifier is 1:1 to 1:20;

combining equal parts of the first aqueous phase and the oil phase to form water in oil (W/O) emulsion;

forming a second aqueous phase by mixing water, stannous ions, and a chelating agent; and

combining the water in oil emulsion and the second aqueous phase to form a stannous ion emulsion complex;

wherein a mass ratio of the water in oil emulsion to the second aqueous phase is 1:1 to 1:10.

2 . The method of claim 1 , wherein the first aqueous phase comprises:

5-90 wt. % of water;

5-30 wt. % of stannous ions; and

5-60 wt. % of the chelating agent, based on a total weight of the first aqueous phase.

3 . The method of claim 1 , wherein the first aqueous phase further comprises less than 2.5 wt. % of a pH buffer, based on a total weight of the first aqueous phase.

4 . The method of claim 1 , wherein the oil phase comprises:

50-95 wt. % the oil; and

5-50 wt. % of the first emulsifier, based on a total weight of the oil phase.

5 . The method of claim 1 , wherein the second aqueous phase comprises:

5-90 wt. % water;

5-30 wt. % of stannous ions; and

5-60 wt. % of the chelating agent, based on a total weight of the second aqueous phase.

6 . The method of claim 1 , wherein the second aqueous phase further comprises less than 5 wt. % of a pH buffer; and less than 20 wt. % of a second emulsifier, based on a total weight of the second aqueous phase.

7 . The method of claim 1 , wherein the stannous ion emulsion complex comprises:

10-50 wt. % of the W/O emulsion; and

50-90 wt. % of the second aqueous phase, based on a total weight of the stannous ion emulsion complex.

8 . The method of claim 1 , wherein the stannous ions are one of stannous fluoride, stannous chloride dihydrate, stannous acetate, stannous gluconate, stannous oxalate, stannous sulfate, stannous lactate, stannous tartrate, and combinations thereof.

9 . The method of claim 1 , wherein the chelating agent is one of GLDA, ASDA, GLDA-4Na, ASDA-4Na, and combinations thereof.

10 . The method of claim 1 , wherein the first emulsifier is one of span-60, span 80, AEO-3, AEO-5, AEO-7, PEG-20, PEG-40, PEG-60, PEG-80, PEG-400, tween-20, tween-60, tween-80, and combinations thereof.

11 . The method of claim 1 , wherein the second emulsifier is one of span-60 span 80, AEO-3, AEO-5, AEO-7, PEG-20, PEG-40, PEG-60, PEG-80, PEG-400, tween-20, tween-60, tween-80, and combinations thereof.

12 . The method of claim 1 , wherein the oil is at least one of α-terpineol, Eugenol, plant oil including coconut oil, soybean oil, corn oil, olive oil vitamin E oil, vitamin C, and combinations thereof.

13 . The method of claim 1 , further comprising dispersing the stannous ion emulsion complex in a solution to form a W/O/W stannous ion composition; and

wherein the W/O/W stannous ion composition has a Sn 2+ stability of above 90% after a 1-month aging test in a 50° C. oven as determine by iodine titration testing.

14 . An oral care product comprising a stable stannous ion complex formed using the method of claim 1 .

15 . A method of preparing an oral care product containing stannous ions, comprising:

forming a first aqueous phase by mixing water, stannous ions, a chelating agent, and a pH buffer;

forming an oil phase by mixing an oil and a first emulsifier;

wherein a ratio of the one oil to the first emulsifier is 1:1 to 1:20;

combining equal parts of the first aqueous phase and the oil phase to form a water in oil (W/O) emulsion;

forming a second aqueous phase by mixing water, stannous ions, a chelating agent, a pH buffer, and a second emulsifier;

combining the water in oil emulsion and the second aqueous phase to form a stannous ion emulsion complex;

wherein a ratio of the water in oil emulsion to the second aqueous phase is 1:1 to 1:10;

dispersing the stannous ion emulsion complex in a solution to form a W/O/W stannous ion composition; and

combining the W/O/W stannous ion composition with an oral care product.

16 . The method of claim 15 , wherein the oral care product is one of toothpaste and mouthwash; and

wherein the oral care product has an antibacterial efficacy of at least 90-99% as determined by WS/T 650-2019 antibacterial test.

17 . The method of claim 15 , wherein the first aqueous phase comprises:

5-90 wt. % of water;

5-30 wt. % of stannous ions;

5-60 wt. % of the chelating agent; and

less than 5 wt. % of pH buffer, based on the total weight of the first aqueous phase.

18 . The method of claim 15 , wherein the oil phase comprises:

50-95 wt. % the oil; and

5-50 wt. % of the first emulsifier, based on the total weight of the oil phase.

19 . The method of claim 15 , wherein the second aqueous phase comprises:

15-90 wt. % of water;

5-20 wt. % of stannous ions;

5-40 wt. % of the chelating agent;

less than 5 wt. % of pH buffer; and

less than 20 wt. % of the second emulsifier, based on the total weight of the second aqueous phase.

20 . The method of claim 15 , wherein the stannous ion emulsion complex comprises:

10-50 wt. % of the O/W emulsion; and

50-90 wt. % of the second aqueous phase, based on the total weight of the stannous ion emulsion complex.