SYSTEMS, METHODS, AND APPARATUS FOR PRODUCING NITRIC OXIDE

1 . A device comprising:

a media configured to convert nitrogen dioxide into nitric oxide, wherein the media comprises:

a) a support material having a specific surface area of 350 to 5000 m 2 /g; wherein the support material is a macroporous, mesoporous, or microporous material; and

b) an antioxidant material, wherein the antioxidant material is present in an amount of greater than 0 wt % to less than 100 wt % based on a total weight of the media.

2 . The device of claim 1 , wherein the support material comprises a molecular sieve, a metal-organic framework (MOF), natural zeolites, synthetic zeolites, polymers of intrinsic microporosity (PIMs), hyper-crosslinked microporous polymers (HCPs), covalent organic frameworks (COFs), conjugated microporous polymers (CMPs), porous aromatic frameworks (PAFs), porous organic cages (PCs), silica gel, or any combination thereof.

3 . The device of claim 2 , wherein the support material further comprises an amount of water.

4 . The device of claim 1 , wherein the support material has a pore size of 1 angstrom to 1000 angstroms; and/or wherein the support material has a pore size of 1 angstrom to 100 angstrom, and/or wherein the support material has a pore size of 1 angstrom to 50 angstrom; and/or wherein the support material has a pore size of less than 40 angstroms.

5 . The device of claim 1 , wherein the antioxidant material:

i) is embedded within at least a portion of the support material; and/or

ii) is substantially uniformly embedded within the support material; and/or

iii) coats at least a portion of the support material; and/or

iv) substantially uniformly coats the support material.

6 . The device of claim 1 , wherein the antioxidant material comprises ascorbic acid; alpha-, beta-, gamma-, or delta tocopherol; alpha-, beta-, gamma-, or delta-tocotrienol; polyphenols; beta-carotene; or a combination thereof.

7 . The device of claim 1 , wherein the media further comprises a polymeric material and/or wherein the media further comprises a gel.

8 . The device of claim 1 , wherein the media is present in a solid form, a granular form, a gel, a liquid form, or any combination thereof.

9 . The device of claim 1 , wherein the media has a moisture content of greater than 0 to less than 100 wt % based on the total weight of the support material.

10 . The device of claim 1 , wherein the antioxidant material is present in an amount greater than 0 wt % to 50 wt % based on the total weight of the media.

11 . The device of claim 1 , wherein the antioxidant material is present in an effective amount to form a predetermined amount of nitric oxide, and/or wherein the support material is present in an effective amount to form a predetermined amount of nitric oxide.

12 . The device of claim 1 , wherein the media is disposed within a vessel.

13 . The device of claim 12 , wherein the media is formed within the vessel and wherein the media conforms to vessel's dimensions.

14 . The device of claim 13 , wherein

i) the media is present in a granular form that fills the vessel's dimensions in an effective amount relative to a volume of the vessel, or

ii) the media is present in a liquid form that fills the vessel's dimensions in an effective amount relative to the volume of the vessel, or

iii) the media is present in a gel form that fills the vessel's dimensions in an effective amount relative to the volume of the vessel.

15 . The device of claim 1 , wherein the media comprises:

a) the support material comprising: 0 to 50 wt % of a polymeric material and greater than 0 wt % to 70 wt % of silica gel, wherein the wt % is calculated based on a total mass of the media; and

b) antioxidant material comprising an ascorbic acid in an amount of greater than 0 to 50 wt %, wherein the wt % is calculated based on the total mass of the media.

16 . The device of claim 15 , wherein the media comprises:

a) the support material comprising: 25 to 35 wt % of a polymeric material and 35 wt % to 55 wt % of silica gel, wherein the wt % is calculated based on the total mass of the media; and

b) antioxidant material comprising an ascorbic acid in an amount of 10 to 40 wt %, wherein the wt % is calculated based on the total mass of the media.

17 . The device of claim 1 , wherein the media comprises:

a) the support material comprising: 0 to less than 100 wt % of a polymeric material and greater than 0 wt % to less than 100 wt % of a natural or synthetic zeolite, wherein the wt % is calculated based on a total mass of the media; and

b) the antioxidant material comprising an ascorbic acid in an amount of greater than 0 to 50 wt %, wherein the wt % is calculated based on the total mass of the media.

18 . The device of claim 17 , wherein the media comprises:

a) the support material comprising: 40 to 70 wt % of a polymeric material and 20 wt % to 40 wt % of a natural or synthetic zeolite, wherein the wt % is calculated based on a total mass of the media; and

b) the antioxidant material comprising an ascorbic acid in an amount of 10 to 25 wt %, wherein the wt % is calculated based on the total mass of the media.

19 . The device of claim 1 , wherein the media comprises:

a) the support material comprising: 0 to less than 100 wt % of a polymeric material and greater than 0 wt % to less than 100 wt % of a metal organic framework, wherein the wt % is calculated based on a total mass of the media; and

b) the antioxidant material comprising an ascorbic acid in an amount of greater than 0 to 50 wt %, wherein the wt % is calculated based on the total mass of the media.

20 . The device of claim 1 , wherein the media is in fluid communication with a source of NO 2 , and/or wherein the media comprises a fluidic pathway configured to transfer formed nitric oxide to a patient.