NEUROACTIVE STEROIDS AND COMPOSITIONS THEREOF
Provided herein is a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R 1a , R 1b , R 2a , R 2b , R 3 , R 4a , R 4b , R 5 , R 6a , R 16b , R 7a , R 7a , R 11a , R 11b , R 12a , R 12b , R 16a , R 16b , R 19 , R 11a , R 22 , R X , R Y and n are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders.
1 - 104 . (canceled)
105 . A compound of Formula (I-e6):
wherein:
each of R 2a , R 2b , R 15a , and R 15b is hydrogen;
R 3 is unsubstituted C 1-3 alkyl, —CH 2 OCH 3 , or —CH 2 OCH 2 CH 3 ;
R 19 is hydrogen, methyl, or ethyl;
R X is —OH;
R Y is methyl; and
R 22 is —CN.
106 . The compound of claim 105 , wherein R 3 is methyl.
107 . The compound of claim 105 , wherein R 3 is ethyl.
108 . The compound of claim 105 , wherein R 3 is propyl.
109 . The compound of claim 105 , wherein R 3 is —CH 2 OCH 3 .
110 . The compound of claim 105 , wherein R 3 is —CH 2 OC 2 H 5 .
111 . The compound of claim 105 , wherein R 19 is hydrogen.
112 . The compound of claim 105 , wherein R 19 is methyl.
113 . A compound selected from:
Com-
pound
No.
Structure
2
3
7
11
15
24
26
29
42
44
114 . The compound of claim 113 , wherein the compound has the structural formula
115 . The compound of claim 113 , wherein the compound has the structural formula
116 . The compound of claim 113 , wherein the compound has the structural formula
117 . The compound of claim 113 , wherein the compound has the structural formula
118 . The compound of claim 113 , wherein the compound has the structural formula
119 . The compound of claim 113 , wherein the compound has the structural formula
120 . The compound of claim 113 , wherein the compound has the structural formula
121 . The compound of claim 113 , wherein the compound has the structural formula
122 . The compound of claim 113 , wherein the compound has the structural formula
123 . The compound of claim 113 , wherein the compound has the structural formula
124 . A pharmaceutical composition comprising a compound according to claim 105 , and a pharmaceutically acceptable excipient.
125 . A pharmaceutical composition comprising a compound according to claim 114 , and a pharmaceutically acceptable excipient.
126 . A pharmaceutical composition comprising a compound according to claim 115 , and a pharmaceutically acceptable excipient.
127 . A pharmaceutical composition comprising a compound according to claim 116 , and a pharmaceutically acceptable excipient.
128 . A pharmaceutical composition comprising a compound according to claim 117 , and a pharmaceutically acceptable excipient.
129 . A pharmaceutical composition comprising a compound according to claim 118 , and a pharmaceutically acceptable excipient.
130 . A pharmaceutical composition comprising a compound according to claim 119 , and a pharmaceutically acceptable excipient.
131 . A pharmaceutical composition comprising a compound according to claim 120 , and a pharmaceutically acceptable excipient.
132 . A pharmaceutical composition comprising a compound according to claim 121 , and a pharmaceutically acceptable excipient.
133 . A pharmaceutical composition comprising a compound according to claim 122 , and a pharmaceutically acceptable excipient.
134 . A pharmaceutical composition comprising a compound according to claim 123 , and a pharmaceutically acceptable excipient.