Systems and Methods for Hemodynamic Monitoring Using a Computational Surrogate for Heart Position

1 . A hemodynamic monitoring system for real-time correction of peripherally sensed blood pressure data, the system comprising:

a display screen;

a first sensor system comprising a blood pressure sensor configured to be attached to a wrist or hand of a patient;

a second sensor system comprising a motion sensor configured to detect displacement of the first sensor system in a vertical direction; and

a computational processing system in digital connection with the first and second sensor systems, the computational processing system comprising:

a processor system; and

a memory system comprising one or more applications that can direct the processor system to:

receive a BP waveform signal acquired from the first sensor system;

determine a set of hemodynamic parameters derived from the BP waveform signal, including a sensed blood pressure parameter;

enter the set of sensed hemodynamic parameters into a trained computational model to yield a corrected blood pressure parameter that accounts for a change in a vertical position of the first sensor system;

detecting a motion of the first sensor system using the second sensor, the motion having a magnitude above a threshold in the vertical direction;

correcting the sensed hemodynamic parameter using the corrected blood pressure parameter based on having detected the motion of the first sensor system; and

displaying the corrected blood pressure parameter on the display screen.

2 . The system of claim 1 , wherein the sensed blood pressure parameter and the corrected blood pressure parameters are the same parameter and are one of: mean arterial pressure (MAP), systolic pressure, and diastolic pressure.

3 . The system of claim 1 , wherein the memory system is further configured to adjust the BP waveform signal based on the corrected blood pressure parameter to correct for the change in the vertical position of the first sensor system.

4 . A method for correcting sensed hemodynamic data in real-time, comprising:

receiving, using hemodynamic monitoring system, sensor signals acquired from a sensor system upon a site of sensing;

determining, using the hemodynamic monitoring system, a set of hemodynamic parameters derived from the sensor signals;

computing, using the hemodynamic monitoring system, a correction that accounts for vertical position of a sensor of the sensor system; and

continually correcting, using the hemodynamic monitoring system, a hemodynamic parameter using the correction that accounts for vertical position of the sensor.

5 . The method of claim 4 , wherein computing, using the hemodynamic monitoring system, the correction that accounts for the vertical position of the sensor system further comprises:

entering, using the hemodynamic monitoring system, a set of hemodynamic parameters into a trained computational model to yield a corrected hemodynamic parameter; and

utilizing, using the hemodynamic monitoring system, the corrected hemodynamic parameter within an equation of invariant inputs to determine the correction that accounts for vertical position of the sensor system, wherein the invariant inputs include the corrected hemodynamic parameter and a sensed hemodynamic parameter, wherein the corrected hemodynamic parameter and the sensed hemodynamic parameter correspond to the same hemodynamic parameter.

6 . The method of claim 5 , wherein the equation of invariant inputs is:

vHP

+

bias

=

sHP

+

vCorr

wherein vHP is the corrected hemodynamic parameter, sHP is a sensed hemodynamic parameter, and vCorr is the correction, and wherein vHP and psHP are the same hemodynamic parameter.

7 . The method of claim 6 , wherein vHP is vMAP and sHP is sMAP.

8 . The method of claim 4 , wherein computing the correction that accounts for vertical position of the sensor system further comprises:

receiving, using the hemodynamic monitoring system, motion detector signals; and

determining, using the hemodynamic monitoring system and based on the motion detector signals, that the correction corresponds to a change in vertical position of the sensor relative to a heart level.

9 . The method of claim 8 , further comprising:

identifying, using the hemodynamic monitoring system, a vertical motion of the sensor system corresponding to a change in vertical position of the sensor system; and

updating, using the hemodynamic monitoring system, the correction that accounts for vertical position of the sensor system.

10 . The method of claim 9 , wherein updating the correction that accounts for vertical position of the sensor system comprises:

entering, using the hemodynamic monitoring system, an updated set of hemodynamic parameters into a trained computational model to yield an updated corrected hemodynamic parameter; and

utilizing, using the hemodynamic monitoring system, the updated corrected hemodynamic parameter within an equation of invariant inputs to determine the correction that accounts for the vertical position of the sensor system, wherein the invariant inputs include the updated corrected hemodynamic parameter and an updated sensed hemodynamic parameter, wherein the updated corrected hemodynamic parameter and the updated sensed hemodynamic parameter correspond to the same hemodynamic parameter.

11 . The method of claim 9 , wherein identifying the motion of the sensor system comprises:

receiving, using the hemodynamic monitoring system, motion detector signals, wherein the motion detector signals indicate that an amount of vertical motion is greater than a threshold.

12 . The method of claim 9 , wherein identifying the motion of the sensor system comprises:

detecting, using the hemodynamic monitoring system, the vertical motion of the sensor system from a computational model trained to detect a change in sensed hemodynamic parameters in response to vertical repositioning of the sensor system.

13 . The method of claim 4 , wherein determining the set of hemodynamic parameters comprises:

performing arterial tonometry, performing volume clamping, performing catheter-based hemodynamic monitoring, performing pulse wave transit time or pulse arrival time, performing photoplethysmography-based heart rate monitoring, or performing arterial pressure sensing via capacitance.

14 . The method of claim 4 , further comprising:

generating, using the hemodynamic monitoring system, a waveform utilizing corrected sensed hemodynamic parameters; or

generating, using the hemodynamic monitoring system, a waveform utilizing downstream hemodynamic parameters.